StudyU: a platform for designing and conducting innovative digital N-of-1 trials

Konigorski, Stefan; Wernicke, Sarah; Slosarek, Tamara; Zenner, Alexander M.; Strelow, Nils; Ruether, Darius Ferenc; Henschel, Florian; Manaswini, Manisha; Pottbäcker, Fabian; Edelman, Jonathan Antonio; Owoyele, Babajide; Danieletto, Matteo; Golden, Eddye; Zweig, Micol; Nadkarni, Girish N.; Böttinger, Erwin P.

doi:10.48550/arxiv.2012.14201

Cited by 1 publication

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“…Another way to reduce costs and barriers is to make it easier for individuals to find relevant trials (or to design their own), complete enrollment procedures, and provide meaningful informed consent. A number of electronic platforms, many created for use on mobile devices, have been used or are in development (Barr et al, 2015;Konigorski et al, 2020;(Kravitz et al, 2020). As point out, however, For clinicians interested in embedding N-of-1 trials in their clinical practice, a personalized trial platform needs to be developed that allows users to customize trial designs according to the use case.…”

Section: Reducing Costs and Burdensmentioning

confidence: 99%

“…Another way to reduce costs and barriers is to make it easier for individuals to find relevant trials (or to design their own), complete enrollment procedures, and provide meaningful informed consent. A number of electronic platforms, many created for use on mobile devices, have been used or are in development ( Barr et al, 2015 )( Bobe et al, 2020 )( Konigorski et al, 2020 )( Kravitz et al, 2020 ). As (n.d.-q) point out, however,…”

Section: Emerging Technologies and Approachesmentioning

confidence: 99%

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Conduct and Implementation of Personalized Trials in Research and Practice

Kravitz

Duan

2022

Harvard Data Science Review

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The mainstay of evidence development in medicine is the parallel-group randomized controlled trial (RCT), which generates estimates of treatment efficacy or effectiveness for the average person in the trial. In contrast, personalized trials (sometimes referred to as 'single-person trials' or 'N-of-1 trials') assess the comparative effectiveness of two or more treatments in a single individual. These single-subject, randomized crossover trials have been used in a scattershot fashion in medicine for over 40 years but have not been widely adopted.An important barrier is the paucity of strong evidence that personalized trials improve outcomes. However, the principal impediment may have less to do with proof of efficacy than with practical aspects of design and implementation. These include decisions about treatment regimen flexibility, blinding, and washout periods as well as organizational, clinician, and patient-level challenges. After reviewing the essential elements of personalized trials, this article addresses these speed bumps and fundamentally asks, 'Why have personalized trials not been more widely adopted, and how can they be made more readily deployable and useful?' The article concludes by suggesting ways in which emerging technologies and approaches promise to overcome existing barriers and open promising vistas for the next generation of personalized-trial researchers and practitioners.

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Section: Reducing Costs and Burdensmentioning

confidence: 99%

“…Another way to reduce costs and barriers is to make it easier for individuals to find relevant trials (or to design their own), complete enrollment procedures, and provide meaningful informed consent. A number of electronic platforms, many created for use on mobile devices, have been used or are in development ( Barr et al, 2015 )( Bobe et al, 2020 )( Konigorski et al, 2020 )( Kravitz et al, 2020 ). As (n.d.-q) point out, however,…”

Section: Emerging Technologies and Approachesmentioning

confidence: 99%

Conduct and Implementation of Personalized Trials in Research and Practice

Kravitz

Duan

2022

Harvard Data Science Review

View full text Add to dashboard Cite

show abstract

StudyU: a platform for designing and conducting innovative digital N-of-1 trials

Cited by 1 publication

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Conduct and Implementation of Personalized Trials in Research and Practice

Conduct and Implementation of Personalized Trials in Research and Practice

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