2024
DOI: 10.1093/bib/bbae051
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STW-MD: a novel spatio-temporal weighting and multi-step decision tree method for considering spatial heterogeneity in brain gene expression data

Shanjun Mao,
Xiao Huang,
Runjiu Chen
et al.

Abstract: Gene expression during brain development or abnormal development is a biological process that is highly dynamic in spatio and temporal. Previous studies have mainly focused on individual brain regions or a certain developmental stage. Our motivation is to address this gap by incorporating spatio-temporal information to gain a more complete understanding of brain development or abnormal brain development, such as Alzheimer’s disease (AD), and to identify potential determinants of response. In this study, we pro… Show more

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