SU(3) symmetry breaking in semileptonic decays

Pandit, L. K.; Rajasekaran, G.

doi:10.1016/0550-3213(69)90267-3

Cited by 6 publications

(2 citation statements)

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“…SOFTWARE NEWS AND UPDATES mainly contributed by improvement in structural alignment of SPalign [24] over TM-align or its variant Fr-TM-align. [17,36] SPalign employs a scoring function that has removed the dependence of protein-protein alignment on protein sizes. Such size independence was shown important in locating partial structural similarity within a large protein.…”

Section: Discussionmentioning

confidence: 99%

“…Template ligands in the dominant binding pockets are utilized for searching similar ligands against a compound library as the traditional ligand homology search approaches. More recently, global receptor-structural alignment by Fr-TM-align [17] in FINDsite was replaced by local binding pocket alignment in PoLi [16] which seems to improve the enrichment factor over FINDsite in standard DUD [18] benchmark databases.…”

Section: Introductionmentioning

confidence: 99%

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SPOT‐Ligand: Fast and effective structure‐based virtual screening by binding homology search according to ligand and receptor similarity

2016

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Structure-based virtual screening usually involves docking of a library of chemical compounds onto the functional pocket of the target receptor so as to discover novel classes of ligands. However, the overall success rate remains low and screening a large library is computationally intensive. An alternative to this "ab initio" approach is virtual screening by binding homology search. In this approach, potential ligands are predicted based on similar interaction pairs (similarity in receptors and ligands). SPOT-Ligand is an approach that integrates ligand similarity by Tanimoto coefficient and receptor similarity by protein structure alignment program SPalign. The method was found to yield a consistent performance in DUD and DUD-E docking benchmarks even if model structures were employed. It improves over docking methods (DOCK6 and AUTODOCK Vina) and has a performance comparable to or better than other binding-homology methods (FINDsite and PoLi) with higher computational efficiency. The server is available at http://sparks-lab.org. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%