Su1070 Features of Upper Gastrointestinal Abnormalities in Non-Alcoholic Steatohepatitis (NASH) Patients

Yamamoto, Shunsuke; Komori, Masato; Satô, Masako; Okahara, Toru; Suzuki, Mana; Nakamura, Masashi; Sueyoshi, Hironari; Yoshii, Shunsuke; Arimoto, Yuki; Hirao, Motohiro; Hosui, Atsushi; Yoshihara, Hiroyuki

doi:10.1016/s0016-5085(13)61438-9

Cited by 2 publications

(4 citation statements)

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“…[ 17 ] as they provided more comprehensive data in the articles. Therefore, eight studies (four cross-sectional studies[ 15 16 19 26 ] and four case–control studies[ 12 14 18 20 ]) with 31,322 participants were included in the final analysis. The literature retrieval, review, and selection process are shown in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Recent studies have suggested that GERD could also be a risk factor for NAFLD although the results were inconsistent. [ 12 13 14 15 16 17 18 19 20 ] To summarize all available data, we conducted this systematic review and meta-analysis of observational studies, which compared the risk of NAFLD among patients with GERD versus those without GERD.…”

Section: Introductionmentioning

confidence: 99%

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Association between gastroesophageal reflux disease and nonalcoholic fatty liver disease: A meta-analysis

Wijarnpreecha¹,

Panjawatanan²,

Jaruvongvanich³

et al. 2017

Saudi J Gastroenterol

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Background/Aim:The relationship between gastroesophageal reflux disease (GERD) and nonalcoholic fatty liver disease (NAFLD) has been demonstrated in recent epidemiologic studies although the results were inconsistent. This meta-analysis was conducted to summarize all available data and to estimate the risk of NAFLD among patients with GERD.Materials and Methods:Comprehensive literature review was conducted using MEDLINE and EMBASE database from inception through November 2016, to identify studies that compared the risk of NAFLD among patients with GERD versus those without GERD. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird.Results:Eight studies (four cross-sectional studies and four case–control studies) with 31,322 participants met the eligibility criteria and were included in the meta-analysis. The risk of NAFLD among patients with GERD was significantly higher than those without GERD with the pooled odds ratio of 2.07 (95% confidence interval, 1.54–2.79). The statistical heterogeneity was high with an I2 of 87%.Conclusions:A significantly increased risk of NAFLD among patients with GERD was observed in this meta-analysis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between gastroesophageal reflux disease and nonalcoholic fatty liver disease: A meta-analysis

Wijarnpreecha¹,

Panjawatanan²,

Jaruvongvanich³

et al. 2017

Saudi J Gastroenterol

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“…Table S2 summarized the main characteristics of these three studies [23][24][25] excluded at the stage of eligibility with the exact reasons for exclusion. Table S2 summarized the main characteristics of these three studies [23][24][25] excluded at the stage of eligibility with the exact reasons for exclusion.…”

Section: Literature Search and Characteristics Of Included Studiesmentioning

confidence: 99%

“…Further, we excluded three studies for the reasons reported in the PRISMA diagram. Table S2 summarized the main characteristics of these three studies [23][24][25] excluded at the stage of eligibility with the exact reasons for exclusion.…”

Section: Literature Search and Characteristics Of Included Studiesmentioning

confidence: 99%

Nonalcoholic fatty liver disease increases the risk of gastroesophageal reflux disease: A systematic review and meta‐analysis

Xue

Hua

Ren

et al. 2019

Eur J Clin Investigation

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Background Increasing evidence indicates that nonalcoholic fatty liver disease (NAFLD) is linked to an increased risk of extra‐hepatic conditions. However, it is currently uncertain whether NAFLD is associated with the risk of gastroesophageal reflux disease (GERD). We performed a systematic review and meta‐analysis of relevant studies to examine the association between NAFLD and the risk of GERD. Methods We searched PubMed, Scopus, Embase and Web of Science from 1 January 1975 to 15 December 2018, using predefined terms to identify cross‐sectional, case‐control and cohort studies investigating the association between NAFLD and GERD. Results Nine observational studies involving 185 118 subjects were eligible for inclusion in the meta‐analysis. Overall, NAFLD was significantly associated with an increased risk of GERD (random effect OR 1.28; 95% CI: 1.12‐1.44, I2 = 82%). Moreover, the significant association between NAFLD and GERD was consistent both for studies with adjusted OR/HR (n = 6, random effect OR = 1.16, 95% CI: 1.03‐1.30) and those with unadjusted OR/HR (n = 3, random effect OR = 2.09, 95% CI: 1.62‐2.56) as measures of effect. Both funnel plot and Egger's test suggested the existence of publication bias. However, a sensitivity analysis by sequentially omitting each study did not alter the pooled outcome,suggesting the robustness of the association. Conclusion NAFLD is associated with an increased risk of GERD. However, future large and cohort studies are still needed to determine the causal relationship between NAFLD and the risk of GERD.

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Su1070 Features of Upper Gastrointestinal Abnormalities in Non-Alcoholic Steatohepatitis (NASH) Patients

Cited by 2 publications

References 0 publications

Association between gastroesophageal reflux disease and nonalcoholic fatty liver disease: A meta-analysis

Association between gastroesophageal reflux disease and nonalcoholic fatty liver disease: A meta-analysis

Nonalcoholic fatty liver disease increases the risk of gastroesophageal reflux disease: A systematic review and meta‐analysis

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