Su1161 The Response Rate After Single and Repeated Doses of Nepadutant As Symptomatic Treatment of Infant Colic: the NO-CRY Phase II Clinical Trial

Over the last few decades, depression has become one of the major public health problems in our society. This problem is connected not only with morbidity, but also with treatment, specifically with the effectiveness of the therapy as well as the concomitant side effects of available antidepressants. Major depressive disorder is a complex clinical entity, including different molecular mechanisms and neurological processes. This complexity is a challenge for scientists seeking to discover an innovatory antidepressant drug with multiple and complementary mechanisms of action. In this review, we discuss the role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in depression and antidepressant-like effects.

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The role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in antidepressant-like effect

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Młyniec

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et al. 2017

Pharmacological Reports

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Su1161 The Response Rate After Single and Repeated Doses of Nepadutant As Symptomatic Treatment of Infant Colic: the NO-CRY Phase II Clinical Trial

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The role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in antidepressant-like effect

The role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in antidepressant-like effect

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