Su2091 Differential Response to Anticoagulation in Germ-Free Swiss Webster Mice Conventionalized With Fecal Transplantation From Human Donors Requiring Varying Doses of Warfarin

Chuang, Philip; Walsh, Emily; Kim, SuBin; Lee, Tae; Hwang, Jaewon; Cho, Ilseung

doi:10.1016/s0016-5085(14)61969-7

Cited by 2 publications

(1 citation statement)

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“…Suppressing the gut biota of warfarin-treated humans by antibiotics often leads to life-threatening overdoses of this anticoagulant. 27 Faecal transplants from humans on high doses of the anticoagulant warfarin to mice conferred warfarin resistance on the mice, 28 demonstrating a possible path for evolving rodent resistance to anticoagulants due to faecal ingestion.…”

Section: Microbiome Organisms Degrade Pesticides In Pestsmentioning

confidence: 99%

Microbiome facilitated pest resistance: potential problems and uses

Gressel

2017

Pest Management Science

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Microbiome organisms can degrade environmental xenobiotics including pesticides, conferring resistance to most types of pests. Some cases of pesticide resistance in insects, nematodes and weeds are now documented to be due to microbiome detoxification, and is a demonstrated possibility with rodents. Some cases of metabolic resistance may have been misattributed to pest metabolism, and not to organisms in the microbiome, because few researchers use axenic pests in studying pesticide metabolism. Instances of microbiomes evolving pesticide resistance contributing to resistance of their hosts may become more common due the erratic nature of climate change, as microbiome populations typically increase and evolve faster in stressful conditions. Conversely, microbiome organisms can be engineered to provide crops and beneficial insects with needed resistance to herbicides and insecticides, respectively, but there has not been sufficient efficacy to achieve commercial products useful at the field level, even with genetically engineered microbiome organisms. © 2017 Society of Chemical Industry.

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Section: Microbiome Organisms Degrade Pesticides In Pestsmentioning

confidence: 99%