Sub‐100 nm, Centimeter‐Scale, Parallel Dip‐Pen Nanolithography

Salaita, Khalid; Lee, Seung Woo; Wang, Xuefang; Huang, Ling; Dellinger, Timothy M.; Liu, Chang; Mirkin, Chad A.

doi:10.1002/smll.200500202

Cited by 127 publications

(104 citation statements)

References 43 publications

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“…To address this problem, a sub-100 nm, centimeter-scale, parallel DPN method using multiple-probes has been recently reported, demonstrating a marked increase in the DPN throughput. [ 22 ] A novel 55000-pen two-dimensional (2D) array was used to pattern gold substrata with sub-100 nm resolution over square centimeter areas. [ 23 ] More recently, polymer pen lithography, which uses a soft elastomeric tip array rather than hard silicon or silicon nitride tips mounted on individual cantilevers, has also emerged as a possible solution.…”

Section: Progress Reportmentioning

confidence: 99%

Biomimetic Nanopatterns as Enabling Tools for Analysis and Control of Live Cells

et al. 2010

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It is becoming increasingly evident that cell biology research can be considerably advanced through the use of bioengineered tools enabled by nanoscale technologies. Recent advances in nanopatterning techniques pave the way for engineering biomaterial surfaces that control cellular interactions from the nano- to the microscale, allowing more precise quantitative experimentation capturing multi-scale aspects of complex tissue physiology in vitro. The spatially and temporally controlled display of extracellular signaling cues on nanopatterned surfaces (e. g., cues in the form of chemical ligands, controlled stiffness, texture, etc.) that can now be achieved on biologically relevant length scales is particularly attractive enabling experimental platform for investigating fundamental mechanisms of adhesion-mediated cell signaling. Here, we present an overview of bio-nanopatterning methods, with the particular focus on the recent advances on the use of nanofabrication techniques as enabling tools for studying the effects of cell adhesion and signaling on cell function. We also highlight the impact of nanoscale engineering in controlling cell-material interfaces, which can have profound implications for future development of tissue engineering and regenerative medicine.

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Section: Progress Reportmentioning

confidence: 99%

Biomimetic Nanopatterns as Enabling Tools for Analysis and Control of Live Cells

et al. 2010

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“…On the other hand, disposable arrays of tens, or even hundreds of cantilevers can be mass produced at low cost by adopting well-established microfabrication techniques used in the semiconductor industry in the last decades. 39,40 Arrays of microcantilevers allow the simultaneous detection of tens of targets, which is demanding for the development of artificial noses, biochemical assays, early disease detection, and prognosis of diseases. Also, cross-sensitivities can be significantly minimized by using cantilever arrays by measuring the differential cantilever bending with respect to one or several cantilevers acting as references.…”

Section: Introductionmentioning

confidence: 99%

High throughput optical readout of dense arrays of nanomechanical systems for sensing applications

Martínez¹,

Kosaka²,

Tamayo³

et al. 2010

Review of Scientific Instruments

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A nano-cheese-cutter to directly measure interfacial adhesion of freestanding nano-fibers J. Appl. Phys. 111, 024315 (2012) Stabilization and growth of non-native nanocrystals at low and atmospheric pressures J. Chem. Phys. 136, 044703 (2012) Nanoparticle production in arc generated fireballs of granular silicon powder AIP Advances 2, 012126 (2012) Stability and topological transformations of liquid droplets on vapor-liquid-solid nanowires J. Appl. Phys. 111, 024302 (2012) Role of RuO3 for the formation of RuO2 nanorods Appl. Phys. Lett. 100, 033108 (2012) Additional information on Rev. Sci. Instrum. We present an instrument based on the scanning of a laser beam and the measurement of the reflected beam deflection that enables the readout of arrays of nanomechanical systems without limitation in the geometry of the sample, with high sensitivity and a spatial resolution of few micrometers. The measurement of nanoscale deformations on surfaces of cm 2 is performed automatically, with minimal need of user intervention for optical alignment. To exploit the capability of the instrument for high throughput biological and chemical sensing, we have designed and fabricated a two-dimensional array of 128 cantilevers. As a proof of concept, we measure the nanometer-scale bending of the 128 cantilevers, previously coated with a thin gold layer, induced by the adsorption and self-assembly on the gold surface of several self-assembled monolayers. The instrument is able to provide the static and dynamic responses of cantilevers with subnanometer resolution and at a rate of up to ten cantilevers per second. The instrumentation and the fabricated chip enable applications for the analysis of complex biological systems and for artificial olfaction.

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“…Moreover, to overcome the serial nature of cantilever-based techniques, parallel approaches can be developed to meet specific requirements in terms of throughput and fabrication costs. [9] For the fabrication of biochips, miniaturized silicon quills bring two main salient features when compared to dip-pen nanolithography (DPN) or related techniques. The first one is that the presence of channels and reservoirs ensuring a continuous liquid transfer is a key factor to keep biomolecules biologically active during the fabrication process.…”

mentioning

confidence: 99%

Fabrication of Oligonucleotide Chips by Using Parallel Cantilever‐Based Electrochemical Deposition in Picoliter Volumes

et al. 2007

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Sub‐100 nm, Centimeter‐Scale, Parallel Dip‐Pen Nanolithography

Cited by 127 publications

References 43 publications

Biomimetic Nanopatterns as Enabling Tools for Analysis and Control of Live Cells

Biomimetic Nanopatterns as Enabling Tools for Analysis and Control of Live Cells

High throughput optical readout of dense arrays of nanomechanical systems for sensing applications

Fabrication of Oligonucleotide Chips by Using Parallel Cantilever‐Based Electrochemical Deposition in Picoliter Volumes

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