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            Mn Manganese Metallotherapeutics

Freeland‐Graves, Jeanne H.; Bose, Tanushree; Karbassian, Abbass

doi:10.1002/0470864052.ch9

Cited by 4 publications

(5 citation statements)

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“…16 The distribution of Mn in the body is dependent on the mitochondrial content of tissues, with the greatest deposition in mitochondrial-rich tissues such as bone, liver, kidneys, pituitary gland, and pancreas. 3 The liver plays a major role in the excretion of surplus Mn, and helps in maintenance of Mn homeostasis. Excess Mn is secreted into the bile by the liver, and subsequently excreted through the feces.…”

Section: Absorption Transport and Excretionmentioning

confidence: 99%

“…Thus, Mn deficiency has adverse effects on skin health and wound healing. 3 The Mn deficiency experiment conducted by the author 25 also resulted in increased levels of serum calcium, phosphorus and alkaline phosphatase (an enzyme involved with active biosynthesis of bone). Elevated serum calcium is of significance as this mineral rarely fluctuates to any great extent owing to homeostatic controls.…”

Section: Deficienciesmentioning

confidence: 99%

“…Chickens, puppies, pigs, and ducks with low blood levels of Mn suffered from poor formation of extremities, resulting in shortened bones and enlargement of joints. 3 Consequently, these malformations often impair mobility. A deficiency of Mn was reported as a consequence of total parenteral nutrition (TPN) before Mn was added as a nutrient to solutions.…”

Section: Deficienciesmentioning

confidence: 99%

“…11 Low dietary intakes of Mn have been associated with a number of health conditions such as skin photo-aging, 51 dyslipidaemia, 52,53 diabetes, 54 metabolic syndrome, 55 hypertension, 56 epilepsy and seizures, 57 cancer, 58 asthma, 59 and inborn metabolic errors of metabolism such as phenylketonuria. 60 Other problems associated with a possible Mn deficiency include inflammatory diseases, 61 altered exocrine and endocrine activities, 3 and problems with fetal growth 62 and cognitive function. 63 A common basis may be related to diminished activity of MnSOD2, an essential antioxidant enzyme.…”

Section: Deficienciesmentioning

confidence: 99%

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Nutritional Requirements for Manganese

Freeland‐Graves¹,

Mousa²,

Sanjeevi³

2014

Manganese in Health and Disease

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Manganese (Mn) is a ubiquitous trace mineral that is essential for living organisms. This mineral is a cofactor of enzymes such as superoxide dismutase and arginase. It assumes a significant role in the metabolism of carbohydrates, amino acids and cholesterol, the formation of bone, digestion, and development. Food sources include whole grains, cereals, green leafy vegetables, nuts, and tea. Approaches to assess Mn requirements include metabolic balance, blood levels, and response of biomarkers. In the United States, the adequate intake (AI) of Mn is 1.8 and 2.3 mg day−1 for women and men, respectively. Negative balance has been reported in numerous studies, where Mn intake was greater than the AI; thus, the adequacy of current dietary recommendations is unclear. Factors that influence Mn requirements include life stage and gender, bioavailability (fiber, phytates, mineral interactions, polyphenolic compounds), and international considerations. Deficiency of Mn has been associated with adverse health conditions including dermatitis, osteoporosis, dyslipidemia, diabetes, metabolic syndrome, hypertension, epilepsy, cancer, asthma, problems with cognitive function, and poor birth outcomes. Toxicity of Mn may be a potential problem with contaminated drinking water, parenteral nutrition, individuals with hepatic dysfunction, and soy formula-fed infants. An understanding of Mn nutrient requirements is important for achievement of optimal health.

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Section: Absorption Transport and Excretionmentioning

confidence: 99%

Section: Deficienciesmentioning

confidence: 99%

Section: Deficienciesmentioning

confidence: 99%

Section: Deficienciesmentioning

confidence: 99%

See 2 more Smart Citations

Nutritional Requirements for Manganese

Freeland‐Graves¹,

Mousa²,

Sanjeevi³

2014

Manganese in Health and Disease

Self Cite

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“…Arginase is an Mn-dependent enzyme that regulates urea production in the liver and nitric oxide synthase in smooth muscle cells (Sarban et al, 2007). Other enzymes that use Mn as a cofactor or activator are involved in the metabolism of carbohydrates, amino acids and cholesterol, the formation of bone and cartilage, and wound healing (Freeland-Graves et al, 2005). These include pyruvate carboxylase, transferases, hydrolases, kinases, 3 lyases, oxidoreductases, isomerases, ligases, glutamine synthetase, and phosphoenolpyruvate decarboxylase (Aschner and Aschner, 2005).…”

Section: Introductionmentioning

confidence: 99%

Specific of accumulation of manganese in organs and tissues of Hereford cattle

Narozhnykh,

Petukhov,

Syso

et al. 2024

Braz. J. Biol.

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The elemental status of cattle is one of the important factors, which determine its growth, fertility, fetal development, meat and dairy production, etc. Therefore, the study of content of different elements in cattle organs and tissues and its correlation with cattle characteristics and diet is urgent task. It is also important to develop intravital and low-invasive methods to analyze element content in cattle to regulate its diet during lifetime. In the present work, we have studied the content and distribution of manganese in Hereford cattle from an ecologically clean zone of Western Siberia (Russia). 252 samples were taken from 31 bulls aged 15-18 months. They were collected from various livestock farms in the region and analyzed using atomic absorption spectrophotometry (organs and muscle tissue) and inductively coupled plasma atomic emission spectrometry (hair). The median values of manganese concentration obtained in natural moisture for hair, heart, kidneys, liver, lungs, muscles, spleen, testes, and brain were 25, 0.37, 1.0, 2.6, 0.4, 0.2, 0.4, 0.5, and 0.5 ppm. Accordingly, the concentration of manganese differs significantly in the organs and tissues of animals (H = 188.6, df = 8, p <0.0001). Statistically significant associations of manganese were revealed in pairs: liver-testis, hair-testis, spleen-testis, and heart-brain. The classification of organs and tissues of animals according to the level of content and variability of manganese is carried out. The concentration of manganese in the body is not uniform, most of all it is deposited in the hair and excretory organs of the liver and kidneys. In other organs and muscle tissues, the distribution of manganese is more even and is in the range of 0.2-0.5 ppm. The resulting ranges can be used as a guideline for Hereford cattle bred in Western Siberia.

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A Mechanistic Study on the Oxidative Degradation of Dibenzazepine Derivatives by Manganese(III) Complexes in Acidic Sulfate Media

Wı́sniewska

Wrzeszcz

2015

Int J of Chemical Kinetics

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The oxidative degradation of tricyclic antidepressants (TCA) was studied in the presence of a large excess of the oxidizing agent manganese(III) and its reduced form manganese(II) sulfate in acidic media. The products were detected and identified using UV-vis, ESI-MS, IR, and EPR methods. The mechanism of the reaction was studied for the following two classes of TCA: 10,11-dihydro-5H-dibenz [b, f]

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₂₅ Mn Manganese Metallotherapeutics

Cited by 4 publications

References 0 publications

Nutritional Requirements for Manganese

Nutritional Requirements for Manganese

Specific of accumulation of manganese in organs and tissues of Hereford cattle

A Mechanistic Study on the Oxidative Degradation of Dibenzazepine Derivatives by Manganese(III) Complexes in Acidic Sulfate Media

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25 Mn Manganese Metallotherapeutics

Cited by 4 publications

References 0 publications

Nutritional Requirements for Manganese

Nutritional Requirements for Manganese

Specific of accumulation of manganese in organs and tissues of Hereford cattle

A Mechanistic Study on the Oxidative Degradation of Dibenzazepine Derivatives by Manganese(III) Complexes in Acidic Sulfate Media

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₂₅ Mn Manganese Metallotherapeutics