₃₃ As Metallotherapeutic Arsenic Compounds

Organometallic compounds in drug discovery: Past, present and future

“…As2O3 (Trisenox®), which is not an organometallic compound, is currently being employed for the treatment of patients with relapsed acute myeloid leukemia. 2,14 Melasorprol (Arsobal®) is still used to treat African sleeping sickness. Although not completely clear, the target of organoarsenical drugs is anticipated to be mitochondrial proteins involved in regulating the production of reactive oxidative species (ROS).…”

Melarsoprol Resistance in African Trypanosomiasis

“…Although NECT has largely supplanted melarsoprol in West Africa for the treatment of gHAT, melarsoprol is still in use today in East Africa as the only effective treatment for advanced stage rHAT. The reader is referred to reviews for a more detailed history of arsenic in medicine [14] and in HAT [15]. Although melarsoprol has been unfairly disparaged as 'arsenic in antifreeze' it has saved countless lives since its introduction for HAT treatment in 1949.…”

Anticancer Activity of Molecular Compounds of Arsenic, Antimony and Bismuth

“…Indeed, it is the emergence of the arsenic containing compound Salvarsan, developed as a 'magic bullet' that probably marks the beginning of modern chemotherapy [19]. However, the use of arsenic in medicine predates Ehrlich by well over 2000 years [20][21][22]. Hippocrates recorded the use of the arsenic sulfur derivatives, realgar (red arsenic, As 2 S 2 ) and orpiment (yellow arsenic, As 2 S 3 ), for the treatment of ulcers.…”