Sub-5 nm lanthanide-doped lutetium oxyfluoride nanoprobes for ultrasensitive detection of prostate specific antigen

Xu, Jin; Zhou, Shanyong; Tu, Datao; Zheng, Wei; Huang, Ping; Li, Renfu; Chen, Zhuo; Huang, Mingdong; Chen, Xueyuan

doi:10.1039/c5sc04599a

Cited by 74 publications

(39 citation statements)

References 36 publications

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“…This chemical damage from weak acid was also found in other rare earth fluoride nanocrystals, such as NaEuF 4 53 and Lu 6 O 5 F 8 . 54 We attributed this to the dissociation of Ln-F bonds of the NaYF 4 nanocrystals in the solution with low pH (r3). We further measured the spectra of NaYF 4 :Yb 3+ ,Er 3+ core-only and core-shell UCNPs in Milli-Q water at various temperatures from 10 1C to 80 1C (shown in Fig.…”

Section: Characterizationmentioning

confidence: 98%

Emission stability and reversibility of upconversion nanocrystals

Liu

Wang

et al. 2016

J. Mater. Chem. C

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Section: Characterizationmentioning

confidence: 98%

Emission stability and reversibility of upconversion nanocrystals

Liu

Wang

et al. 2016

J. Mater. Chem. C

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“…As UC fluorescence probes in biological detections and imaging, these Ln 3+ -doped UCNPs should emit strong UC luminescence under infrared excitation in order to achieve high sensitivity and resolution. In the most of cases, the UCNPs are also required to have both small size (sub-50 nm) and hydrophilic surface in order to meet the post biological functionalization [ 9 – 14 ]. Among numerous UC materials, Ln 3+ activator-doped rare earth fluorides, especially hexagonal phase NaREF 4 (RE = Y, Gd, Lu), are considered ideal candidates for probes because of their efficient UC luminescence.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Luminescence Properties of Water Soluble α-NaGdF4/β-NaYF4:Yb,Er Core–Shell Nanoparticles

et al. 2017

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Hexagonal phase (β) sodium rare earth tetrafluorides (NaREF4, RE = Y, Gd, Lu, et al.) are considered the ideal matrices for lanthanide (Ln) ions doped upconversion (UC) luminescence materials, because they can provide favorable crystal lattice structures for the doped luminescent Ln ions to make intensive emissions. However, the cubic phase (α) NaREF4 always preferentially forms at low reaction temperature in short time as it is dynamically stable. Therefore, it is hard to obtain small sized β-NaREF4 via the traditional solvothermal method. In this paper, small sized β-NaYF4:Yb,Er nanoparticles were synthesized by a heterogeneous-core-induced method via the solvothermal reaction. The heterogeneous α-NaGdF4/β-NaYF4: Yb, Er core–shell structure was confirmed by the local elemental mapping. The formation mechanism of β-NaYF4:Yb,Er shell on the surface of α-NaGdF4 core was explained in detail. We reasoned that a hetero interface with a lower lattice symmetric structure was produced by cation exchanges between the core and shell, which caused the preferential growth of anisotropic hexagonal phase shell. The existence of this hetero interface has also been proven by observation of Gd3+ UC emission.

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“…-doped NPs exhibiting visible emissions have been developed for bioassays [111][112][113][114][115][116] (Fig. 9b, c).…”

Section: +mentioning

confidence: 99%

Lanthanide-doped near-infrared II luminescent nanoprobes for bioapplications

Lian

et al. 2019

Sci. China Mater.

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Luminescent biosensing in the second nearinfrared (NIR-II) region is featured with superior spatial resolution and high penetration depth by virtue of the suppressed scattering of long-wavelength photons. Hitherto, the reported NIR-II nanoprobes are mostly based on carbon nanotubes, organic fluorophores or semiconducting quantum dots. As an alternative, trivalent lanthanide ions (Ln 3+) doped nanoparticles have been emerging as a novel class of promising nanoprobes. In this review, we highlight the recent progress in the design of highly efficient Ln 3+-doped NIR-II nanoparticles towards their emerging bioapplications, with an emphasis on autofluorescence-free bioimaging, sensitive bioassay, and accurate temperature sensing. Moreover, some efforts and challenges towards this rapidly expanding field are envisioned.

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Sub-5 nm lanthanide-doped lutetium oxyfluoride nanoprobes for ultrasensitive detection of prostate specific antigen

Abstract: We demonstrate the successful use of sub-5 nm Lu6O5F8:Eu3+ nano-bioprobes for the ultrasensitive detection of prostate specific antigen in patient serum samples with a limit of detection of 0.52 pg mL–1.

Cited by 74 publications

References 36 publications

Emission stability and reversibility of upconversion nanocrystals

Emission stability and reversibility of upconversion nanocrystals

Synthesis and Luminescence Properties of Water Soluble α-NaGdF4/β-NaYF4:Yb,Er Core–Shell Nanoparticles

Lanthanide-doped near-infrared II luminescent nanoprobes for bioapplications

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