Sub Acute Toxicity Assessment of Glipizide Engineered Polymeric Nanoparticles

lekshmi, U.M. Dhana; Kishore, Narra; Reddy, P. Neelakanta

doi:10.1166/jbn.2011.1317

Cited by 23 publications

(13 citation statements)

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“…This means that NG3 is superior to NG2 and NG1 for topical therapeutic effect. 43 These results agree with previous studies on NEs, which suggested that 1) hair follicles and sweat glands play an important role in transdermal drug delivery systems 41,44 and 2) gel matrixes can increase drug retention time in the epidermis. 45 Comparison with NE indicated that as the proportion of CP934 increased in the NGs, the main skin delivery routes were altered and the skin permeation profiles were changed from the transdermal mode to topical drug delivery.…”

Section: Figuresupporting

confidence: 92%

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Zheng¹,

Ouyang²,

Wei³

et al. 2016

IJN

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Section: Figuresupporting

confidence: 92%

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Zheng¹,

Ouyang²,

Wei³

et al. 2016

IJN

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“…According to the literature, these results are comparable and even superior to previously reported results of the sizes of NPs used for intracellular sensing . Moreover, in view of the reported very weakly toxic or nontoxic natures of the acrylate polymeric NPs, the BA fluorescent azide/amine‐perylene NPs prepared here have full potential to be used in intracellular sensing …”

Section: Methodssupporting

confidence: 84%

New Fluorescent Nanoparticles for Ultrasensitive Detection of Nucleic Acids by Optical Methods

et al. 2017

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For decades the detection of nucleic acids and their interactions at low abundances has been a challenging task that has thus far been solved by enzymatic target amplification. In this work we aimed at developing efficient tools for amplification-free nucleic acid detection, which resulted in the synthesis of new fluorescent nanoparticles. Here, the fluorescent nanoparticles were made by simple and inexpensive radical emulsion polymerization of butyl acrylate in the presence of fluorescent dyes and additional functionalization reagents. This provided ultra-bright macrofluorophores of 9-84 nm mean diameter, modified with additional alkyne and amino groups for bioconjugation. By using click and NHS chemistries, the new nanoparticles were attached to target-specific DNA probes that were used in fluorimetry and fluorescence microscopy. Overall, these fluorescent nanoparticles and their oligonucleotide derivatives have higher photostability, brighter fluorescence and hence dramatically lower limits of target detection than the individual organic dyes. These properties make them useful in approaches directed towards ultrasensitive detection of nucleic acids, in particular for imaging and in vitro diagnostics of DNA.

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“…It is worthy to note that because of the plastic and hydrophobic nature of EC, drug particles near the surface of the matrix could be initially released into the surrounding medium, resulting in the increase in the pores and thus facilitating further drug release and the initial burst effect. 41 …”

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confidence: 99%

Design and formulation of a topical hydrogel integrating lemongrass-loaded nanosponges with an enhanced antifungal effect: in vitro/in vivo evaluation

Aldawsari¹,

Badr-Eldin²,

Labib³

et al. 2015

IJN

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Lemongrass oil (LGO) is a volatile oil extracted from the leaves of Cymbopogon citratus that has become one of the most important natural oils in the pharmaceutical industry because of its diverse pharmacologic and clinical effects. However, LGO suffers from low aqueous solubility, which could lead to a reduced effect. Moreover, the instability of its major active constituent, citral, could lead to volatilization, reaction with other formulation ingredients, and consequently, skin irritation. To surmount these problems, this research aims to formulate lemongrass-loaded ethyl cellulose nanosponges with a topical hydrogel with an enhanced antifungal effect and decreased irritation. The minimal inhibitory concentration and minimal fungicidal concentration of LGO against Candida albicans strain ATC 100231, determined using the broth macrodilution method, were found to be 2 and 8 μL/mL, respectively. The emulsion solvent evaporation technique was used for the preparation of the nanosponges. The nanosponge dispersions were then integrated into carbopol hydrogels (0.4%). Nine formulations were prepared based on a 3 2 full factorial design employing the ethyl cellulose:polyvinyl alcohol ratio and stirring rate as independent variables. The prepared formulations were evaluated for particle size, citral content, and in vitro release. Results revealed that all the nanosponge dispersions were nanosized, with satisfactory citral content and sustained release profiles. Statistical analysis revealed that both ethyl cellulose:polyvinyl alcohol ratio and stirring rate have significant effects on particle size and percentage released after 6 hours; however, the effect of the stirring rate was more prominent on both responses. The selected hydrogel formulation, F9, was subjected to surface morphological investigations, using scanning and transmission electron microscopy, where results showed that the nanosponges possess a spherical uniform shape with a spongy structure, the integrity of which was not affected by integration into the hydrogel. Furthermore, the selected formulation, F9, was tested for skin irritation and antifungal activity against C. albicans , where results confirmed the nonirritancy and the effective antifungal activity of the prepared hydrogel.

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Sub Acute Toxicity Assessment of Glipizide Engineered Polymeric Nanoparticles

Cited by 23 publications

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Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

New Fluorescent Nanoparticles for Ultrasensitive Detection of Nucleic Acids by Optical Methods

Design and formulation of a topical hydrogel integrating lemongrass-loaded nanosponges with an enhanced antifungal effect: in vitro/in vivo evaluation

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Sub Acute Toxicity Assessment of Glipizide Engineered Polymeric Nanoparticles

Cited by 23 publications

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Effects of Carbopol<sup>&reg;</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Effects of Carbopol<sup>&reg;</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

New Fluorescent Nanoparticles for Ultrasensitive Detection of Nucleic Acids by Optical Methods

Design and formulation of a topical hydrogel integrating lemongrass-loaded nanosponges with an enhanced antifungal effect: in vitro/in&nbsp;vivo&nbsp;evaluation

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Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Effects of Carbopol<sup>®</sup> 934 proportion on nanoemulsion gel for topical and transdermal drug delivery: a skin permeation study

Design and formulation of a topical hydrogel integrating lemongrass-loaded nanosponges with an enhanced antifungal effect: in vitro/in vivo evaluation