Sub-acute toxicity profile of a modified resveratrol supplement

Sangeetha, M.; Vallabi, D. Eazhisai; Sali, Veeresh Kumar; Thanka, J; Vasanthi, Hannah R.

doi:10.1016/j.fct.2013.06.037

Cited by 25 publications

(13 citation statements)

References 29 publications

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“…The direct administration of moderate doses of resveratrol seem to be safe and cardioprotective [104]. Accordingly, the use of a resveratrol supplement (Longevinex) did not seem to elicit any adverse effects in an animal study, indicating beneficial effects and safe use [105]. At the same time, grape-seed extract seems to also be safe for healthy rats, even in high repeated doses, and revealed antioxidative and anti-inflammatory properties [90].…”

Section: Safety In the Polyphenol Worldmentioning

confidence: 92%

Polyphenols from Food and Natural Products: Neuroprotection and Safety

2020

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Polyphenols are naturally occurring micronutrients that are present in many food sources. Besides being potent antioxidants, these molecules may also possess anti-inflammatory properties. Many studies have highlighted their potential role in the prevention and treatment of various pathological conditions connected to oxidative stress and inflammation (e.g., cancer, and cardiovascular and neurodegenerative disorders). Neurodegenerative diseases are globally one of the main causes of death and represent an enormous burden in terms of human suffering, social distress, and economic costs. Recent data expanded on the initial antioxidant-based mechanism of polyphenols’ action by showing that they are also able to modulate several cell-signaling pathways and mediators. The proposed benefits of polyphenols, either as protective/prophylactic substances or as therapeutic molecules, may be achieved by the consumption of a natural polyphenol-enriched diet, by their use as food supplements, or with formulations as pharmaceutical drugs/nutraceuticals. It has also been proved that the health effects of polyphenols depend on the consumed amount and their bioavailability. However, their overconsumption may raise safety concerns due to the accumulation of high levels of these molecules in the organism, particularly if we consider the loose regulatory legislation regarding the commercialization and use of food supplements. This review addresses the main beneficial effects of food polyphenols, and focuses on neuroprotection and the safety issues related to overconsumption.

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Section: Safety In the Polyphenol Worldmentioning

confidence: 92%

Polyphenols from Food and Natural Products: Neuroprotection and Safety

2020

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“…Generic RV can be photo-isomerized from trans to cis RV by exposure to ultraviolet radiation. For these reasons we selected a commercially available brand of resveratrol that had been stabilized via microencapsulation and tested and shown to work superiorly to plain resveratrol and has undergone toxicity testing [ 11 ]. L/RV, an OTC oral RV-based supplement, contains microencapsulated/microionized RV and a blend of red wine polyphenols, primarily quercetin, along with vitamin D 3 , and inositol hexaphosphate (IP6).…”

Section: Methodsmentioning

confidence: 99%

“…This margin of safety is clearly superior to RV alone. L/RV passed toxicity testing, meeting the New Dietary Ingredient guidelines described by the FDA [ 11 , 21 ]. This dietary supplement exhibits good safety and the recommended dosage (one capsule per day) and has not produced major side effects among non-anemic subjects over a ten-year period of commercial use [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Resveratrol Based Oral Nutritional Supplement Produces Long-Term Beneficial Effects on Structure and Visual Function in Human Patients

et al. 2014

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Background: Longevinex® (L/RV) is a low dose hormetic over-the-counter (OTC) oral resveratrol (RV) based matrix of red wine solids, vitamin D3 and inositol hexaphosphate (IP6) with established bioavailability, safety, and short-term efficacy against the earliest signs of human atherosclerosis, murine cardiac reperfusion injury, clinical retinal neovascularization, and stem cell survival. We previously reported our short-term findings for dry and wet age-related macular degeneration (AMD) patients. Today we report long term (two to three year) clinical efficacy. Methods: We treated three patients including a patient with an AMD treatment resistant variant (polypoidal retinal vasculature disease). We evaluated two clinical measures of ocular structure (fundus autofluorescent imaging and spectral domain optical coherence extended depth choroidal imaging) and qualitatively appraised changes in macular pigment volume. We further evaluated three clinical measures of visual function (Snellen visual acuity, contrast sensitivity, and glare recovery to a cone photo-stress stimulus). Results: We observed broad bilateral improvements in ocular structure and function over a long time period, opposite to what might be expected due to aging and the natural progression of the patient’s pathophysiology. No side effects were observed. Conclusions: These three cases demonstrate that application of epigenetics has long-term efficacy against AMD retinal disease, when the retinal specialist has exhausted other therapeutic modalities.

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“…Resveratrol (trans-3,5,4′-trihydroxystilbene, C 14 H 12 O 3 , MW 228.2), a polyphenolic compound, possesses multifaceted pharmacological activities [1][2][3] and, importantly, resveratrol is not harmful to normal cells/tissues of the central nervous system [4,5]. Because of the lipophilic nature of resveratrol, it is able to penetrate the cell membrane via simple diffusion.…”

Section: Introductionmentioning

confidence: 99%

Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications

Shu

Wang

et al. 2015

Neurotherapeutics

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Resveratrol possesses anti-tumor activities against central nervous system (CNS) tumors in vitro but has not yet been used clinically due to its low bioavailability, particularly in the CNS. This study thus aimed to elucidate brain bioavailability of trans-resveratrol by monitoring brain concentrations and dwell times following administration of resveratrol through intragastric, intraperitoneal, external carotid artery/ ECA and intrathecal routes. In parallel, we evaluated the biological responses of rat RG2 glioblastoma cells as well as RG2-formed rat intracranial glioblastomas treated with resveratrol via intrathecal administration. The results revealed that resveratrol was detected in rat brains except when administered systemically. Intrathecal administration of reseveratrol led to abundant apoptotic foci and increased staining of the autophagy proteins, LC-3 and Beclin-1 and shrinkage of the intracranial tumors. In conclusion, the BBB penetrability of resveratrol is remarkably increased by intracthecal administration. Regular short-term resveratrol treatments suppress growth and enhance autophagic and apoptotic activities of rat RG2 glioblastoma cells in vitro and in vivo. Therefore, intrathecal administration of resveratrol could be an optimal intervention approach in the adjuvant management of brain malignancies.

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Sub-acute toxicity profile of a modified resveratrol supplement

Cited by 25 publications

References 29 publications

Polyphenols from Food and Natural Products: Neuroprotection and Safety

Polyphenols from Food and Natural Products: Neuroprotection and Safety

Resveratrol Based Oral Nutritional Supplement Produces Long-Term Beneficial Effects on Structure and Visual Function in Human Patients

Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications

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