Sub-acute toxicity studies on the aqueous extract of &lt;i&gt;Stereospermum kunthianum&lt;/i&gt; (Cham, Sandrine Petit) stem bark

Okpo, Stephen O; Ching, Fidelis P

doi:10.4314/jpb.v10i2.1

Cited by 3 publications

(3 citation statements)

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“…Indeed, the limit test is carried out when there are data relating to the absence or very low toxicity of a substance. Previous studies on the acute toxicity of the aqueous extract of the stem bark of S. kunthianum did not show toxicity even after administration of a single dose of 8000 mg/ kg body weight [20,21]. This study clearly confirms our results which estimate that the LD 50 would be greater than or equal to 2000 mg/kg.…”

Section: Evolution Of Body Masssupporting

confidence: 91%

“…Our hydroethanolic extract would therefore not cause any impairment of hepatic, renal, or cardiac functions. Indeed, in the event of hepatic, cardiac, or renal lesions, an increase in serum ureacreatinine and transaminase activity is observed [21]. On the other hand, the study by Okpo and Ching found a rise in ALT after administration of an aqueous extract at a dose of 2000 mg/kg [22].…”

Section: Discussionmentioning

confidence: 99%

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Acute and Sub-Acute Toxicity Studies on the Trunk Bark Hydro-Ethanolic Extract of Stereospermum kunthianum Cham: In Wistar Rats

Dieynaba¹,

Abdou²,

Fatoumata³

et al. 2023

J Toxicol Risk Assess

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Purpose:The aim of the present study was to evaluate the acute and sub-acute toxicity of the trunk bark hydroethanolic extract of Stereospermum Kunthianum Cham: in Wistar rats. Methods:For acute toxicity assessment, three 12-week-old female rats were administered by gavage a single oral dose of 2000 mg/kg of the trunk bark hydro-ethanolic extract of Stereospermum kunthianum. LD 50 was estimated after 14 days of observation. Subacute toxicity was assessed at three dose levels: 500, 1000, and 2000 mg/kg. The extract was administered by gavage to a batch of 6 male and female rats, daily for 28 days. Each batch consisted of 3 males and 3 males. A 4 th batch that received only distilled water was used as a control. Monitoring body weight was carried out, and urinalysis, haematological, and biochemical analyses were carried out on urine, whole blood, and serum samples. Results:The results showed that the hydroethanolic extract of trunk bark and hydro-ethanolic extract of Stereospermum kunthianum did not result in death among the animals; there were no obvious signs of toxicity. However, in animals that received the extract for 28 days, two deaths were noted in females, macroscopic examination also showed stomach distension compared to the controls. These stomach distension which was dose dependent without any disturbance of the determined biological parameters. Conclusion:According to these results, LD 50 was estimated to be greater than 2000 mg/kg. Female rats appear to be more sensitive than males in long-term. NOAEL was estimated below 500 mg/kg. The results showed that the trunk bark hydro-ethanolic extract of Stereospermum kunthianum Cham. Has low or no toxicity in Wistar rats at tested doses.

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Section: Evolution Of Body Masssupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Acute and Sub-Acute Toxicity Studies on the Trunk Bark Hydro-Ethanolic Extract of Stereospermum kunthianum Cham: In Wistar Rats

Dieynaba¹,

Abdou²,

Fatoumata³

et al. 2023

J Toxicol Risk Assess

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“…This level considers a test compound practically non-toxic on an acute exposure (OECD, 2001). Okpo and Ching (2013) had previously recorded no acute adverse behavioural effects or mortality in Swiss mice given an oral dose of the extract at 8000 mg kg -1 .…”

Section: Discussion Discussion Discussionmentioning

confidence: 99%

Hypoglycemic and in vitro antioxidant activities of Stereospermum kunthianum stem bark hydromethanol extract

et al. 2022

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This study investigated Stereospermum kunthianum stem bark hydromethanol extract for hypoglycemic and in vitro antioxidant activities. Phytochemical analyses were performed to determine the components of the extract. In vitro antioxidant activities of the extract were assessed with 1, 1-diphenyl-2-picrylhydrazyl radical scavenging and ferric reducing /antioxidant power assays. An oral acute toxicity study to determine the safe dose of the extract was conducted in albino Wistar rats. Evaluation of the extract's hypoglycemic activities on blood glucose levels of normal, glucose loaded and streptozotocin-induced diabetic rats were performed. The extract contained various constituents, including saponins, terpenes, tannins, flavonoids, carbohydrates, alkaloids, and steroids. 1, 1-diphenyl-2-picrylhydrazyl radical scavenging assay proved more sensitive, showing a concentration-dependent increase in antioxidant capacity of the extract, which peaked at 71.8% relative to ascorbic acid (92.9%) at the highest test concentration (400 μg mL-1). The rats tolerated Stereospermum kunthianum extracts with the oral LD50 of more than 5000 mg kg-1. Interestingly, various doses (100-400 mg kg-1) of the extract were effective in causing significant (p≤0.05) reductions in the blood glucose levels of normoglycemic, glucose challenged and streptozotocin-induced diabetic rats when compared to their controls. The results suggest that the stem bark extract of S. kunthianum was a relatively safe herbal extract, rich in phytochemicals, possessed good antioxidant activity, with potential anti-diabetic effects.

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Anti-hypercholesterolemic potential of diet supplemented with Anchomanes difformis and Pleurotus tuberregium tubers in high cholesterol fed rats

Oyetayo

Akomolafe

Ogundumi

2020

J Diabetes Metab Disord

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Sub-acute toxicity studies on the aqueous extract of <i>Stereospermum kunthianum</i> (Cham, Sandrine Petit) stem bark

Cited by 3 publications

References 0 publications

Acute and Sub-Acute Toxicity Studies on the Trunk Bark Hydro-Ethanolic Extract of Stereospermum kunthianum Cham: In Wistar Rats

Acute and Sub-Acute Toxicity Studies on the Trunk Bark Hydro-Ethanolic Extract of Stereospermum kunthianum Cham: In Wistar Rats

Hypoglycemic and in vitro antioxidant activities of Stereospermum kunthianum stem bark hydromethanol extract

Anti-hypercholesterolemic potential of diet supplemented with Anchomanes difformis and Pleurotus tuberregium tubers in high cholesterol fed rats

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