Sub-acute toxicological effects of Jobelyn® on pregnant albino rats

Adebayo, Abiodun Humphrey; Yakubu, Omolara Faith; Egbung, Godwin Eneji; Williams, Olabisi Ibidun; Okubena, Olajuwon

doi:10.1063/1.5033398

Cited by 3 publications

(12 citation statements)

References 29 publications

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“…It is obtained from the polyphenol-rich leaf sheaths (Figure 2A) of a West African variety of Sorghum bicolor L. Moench (Poaceae). S. bicolor, commonly known as millet, sweet sorghum, broom, or guinea corn, is widely cultivated across many tropical countries of the world for its economic, nutritional, and medicinal values [14][15]. Accordingly, S. bicolor plant-based regimens have been used for well over a century in treating various ailments in African traditional medical settings [20][21].…”

Section: Source Of Sbsjmentioning

confidence: 99%

“…Accordingly, S. bicolor plant-based regimens have been used for well over a century in treating various ailments in African traditional medical settings [20][21]. In fact, folklore medical practices have revealed that herbal concoctions of the root are used as an antimalarial, especially by natives of Southern Rhodesia, while seed (grain)-based concoctions are used to treat diarrhoea and breast cancer, as well as for their anti-inflammatory effects [14,21]. Extracts from the stem are used as an antitubercular oedema regimen, while the leaf is utilized for a wide range of ailments [9,14,21].…”

Section: Source Of Sbsjmentioning

confidence: 99%

“…In fact, folklore medical practices have revealed that herbal concoctions of the root are used as an antimalarial, especially by natives of Southern Rhodesia, while seed (grain)-based concoctions are used to treat diarrhoea and breast cancer, as well as for their anti-inflammatory effects [14,21]. Extracts from the stem are used as an antitubercular oedema regimen, while the leaf is utilized for a wide range of ailments [9,14,21]. Of particular note, the extract from the leaf-sheaths component of S. bicolor-from which SBSJ is claimed to be exclusively obtained-tends to exhibit better therapeutic effects against diverse diseases over those derived from other parts of the plant [14].…”

Section: Source Of Sbsjmentioning

confidence: 99%

“…Extracts from the stem are used as an antitubercular oedema regimen, while the leaf is utilized for a wide range of ailments [9,14,21]. Of particular note, the extract from the leaf-sheaths component of S. bicolor-from which SBSJ is claimed to be exclusively obtained-tends to exhibit better therapeutic effects against diverse diseases over those derived from other parts of the plant [14].…”

Section: Source Of Sbsjmentioning

confidence: 99%

“…SBSJ has an FDA (USA) GRAS certification with an organ systems tolerance profile [14,23]. It has also has gained local and international recognition for the treatment of moderate to severe anaemia (as in sickle cell patients), as well as cancer and HIV/AIDS [19,24].…”

Section: Source Of Sbsjmentioning

confidence: 99%

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Polyphenol Rich Nutritional Supplement Derived from the West African Sorghum Bicolor Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Okubena¹,

Adebesin²,

Omogbiya³

et al. 2022

Preprint

Self Cite

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Across different cultures around the globe, human beings have historically depended largely on medicinal plants for managing diseases that have hitherto threatened their optimal health, survival, and longevity. Evidently, the health-derived benefits of medicinal plants can be strongly attributed to the presence of secondary metabolites, particularly polyphenols. The health-promoting effects of Sorghum bicolor supplement Jobelyn® (SBSJ) —a unique supplement derived from the leaf sheaths of a West African variety of Sorghum bicolor (L.) Moench—have also been ascribed to its high levels of polyphenols. This review seeks to gather and synthesize findings from various experimental and clinical studies on the health benefits of SBSJ in arthritis, cancer, chronic viral infections, stroke, anaemia, and aging. SBSJ has been reported to contain potent bioactive polyphenolic compounds with polyvalent biological activities, including antioxidant, anti-inflammatory, immunomodulatory, chemopreventive, and neuroprotective activities. Moreover, the probable benefits of SBSJ in chronic viral infections (e.g., HIV/AIDS and COVID-19) have been attributed to its potent anti-inflammatory and immunomodulatory activities. As this supplement is increasingly becoming one of the fastest-selling herbal medicines in Nigeria, there is a need for more robust studies (including clinical trials) in order to replicate and validate the prior insights gleaned from experimental studies.

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Section: Source Of Sbsjmentioning

confidence: 99%

Section: Source Of Sbsjmentioning

confidence: 99%

Section: Source Of Sbsjmentioning

confidence: 99%

Section: Source Of Sbsjmentioning

confidence: 99%

Section: Source Of Sbsjmentioning

confidence: 99%

See 3 more Smart Citations

Polyphenol Rich Nutritional Supplement Derived from the West African Sorghum Bicolor Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Okubena¹,

Adebesin²,

Omogbiya³

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

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Sorghum bicolor polyphenol-rich extract improves insulin sensitivity and protect against chronic stress exacerbated diabetic nephropathy through modulation of Nrf2/NF-κB

Ajayi,

Akintelu,

Igari

et al. 2024

Obesity Medicine

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An Evidence-based Systematic Review of Pleiotropic Potential Health Benefits of Sorghum bicolor Supplement: A Polyphenol-rich Derivative of the Leaf Sheaths of Sorghum Plant

Adebesin,

Omogbiya,

Oluwole

et al. 2024

JNR

Self Cite

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Globally, across different cultures, humans have historically depended largely on medicinal plants for managing diseases that have hitherto threatened their optimal health, survival, and longevity. Evidently, the health-derived benefits of medicinal plants have been strongly attributed to the presence of secondary metabolites, particularly polyphenols. The potential health benefits of the leaf sheaths of the West African variety of Sorghum bicolor-based Jobelyn Supplement (SBJS) have also been ascribed to its high contents of polyphenols. This systematic review seeks to synthetically harmonize findings from various experimental and clinical studies on the health benefits of SBJS in different disease conditions including arthritis, cancer, chronic viral infections, stroke, anaemia, and premature aging. A systematic search was conducted using three primary databases (PubMed, Europe PMC, and Cochrane Library), to identify published articles on therapeutic potentials of SBJS and ethnomedicinal surveys on the application of the West African variety of S. bicolor using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) standard. The inclusion criteria were experimental and clinical studies conducted on SBJS and West African variety of S. bicolor; while ethnomedicinal surveys were on the therapeutic uses of the West African variety of S. bicolor published in the English language. The review provides valuable information suggesting that SBJS possesses pleiotropic therapeutic potentials in diverse pathological conditions through mechanisms relating to antioxidant, anti-inflammatory, immunomodulatory, chemopreventive, and neuroprotective activities. The review also showed that SBJS contains several bioactive substances with polyvalent pharmacological potentials including modulation of pathological mechanisms involved in the mediation of aging and age-related diseases, such as arthritis, stroke, memory loss and cancer as well as chronic viral infections. Taken together, these findings further suggest the need for more robust studies (including disease-specific clinical trial programs) in order to replicate and validate the prior insights gleaned from previous investigations on SBJS.

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Sub-acute toxicological effects of Jobelyn® on pregnant albino rats

Cited by 3 publications

References 29 publications

Polyphenol Rich Nutritional Supplement Derived from the West African <em>Sorghum Bicolor</em> Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Polyphenol Rich Nutritional Supplement Derived from the West African <em>Sorghum Bicolor</em> Leaf Sheaths Has Evidence-Based Efficacy and Health Promoting Effects

Sorghum bicolor polyphenol-rich extract improves insulin sensitivity and protect against chronic stress exacerbated diabetic nephropathy through modulation of Nrf2/NF-κB

An Evidence-based Systematic Review of Pleiotropic Potential Health Benefits of <i>Sorghum bicolor</i> Supplement: A Polyphenol-rich Derivative of the Leaf Sheaths of <i>Sorghum</i> Plant

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