Sub-chronic and mild social defeat stress exposure to C57BL/6J mice increases visceral fat mass and causes accumulation of cholesterol and bile acids in the liver

Morito, Katsuya; Yamagata, Mayu; Naka, Futaba; Kobayashi, Kayo; Ueda, Hikari; Morimoto, Hirotoshi; Yasukawa, Takeshi; Takayama, Kentaro; Uozumi, Yoshinobu; Nagasawa, Kazuki

doi:10.1016/j.bbrc.2024.149631

Biochemical and Biophysical Research Communications

2024

DOI: 10.1016/j.bbrc.2024.149631

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Sub-chronic and mild social defeat stress exposure to C57BL/6J mice increases visceral fat mass and causes accumulation of cholesterol and bile acids in the liver

Katsuya Morito,

Mayu Yamagata,

Futaba Naka

et al.

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Adaptations in hepatic glucose metabolism after chronic social defeat stress in mice

Meijboom,

Hasch,

Ruiz de Azua

et al. 2024

Sci Rep

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Chronic stress has been shown to induce hyperglycemia in both peripheral blood and the brain, yet the detailed mechanisms of glucose metabolism under stress remain unclear. Utilizing 13C6-labeled glucose to trace metabolic pathways, our study investigated the impact of stress by chronic social defeat (CSD) on glucose metabolites in the liver and brain one week post-stress. We observed a reduction in 13C6-enrichment of glucose metabolites in the liver, contrasting with unchanged levels in the brain. Notably, hepatic glycogen levels were reduced while lactate concentrations were elevated, suggesting lactate as an alternative energy source during stress. Long-term effects were also examined, revealing normalized blood glucose levels and restored glycogen stores in the liver three weeks post-CSD, despite sustained increases in food intake. This normalization is hypothesized to result from diminished glucagon levels leading to reduced glycogen phosphorylase activity. Our findings highlight a temporal shift in glucose metabolism, with hyperglycemia and glycogen depletion in the liver early after CSD, followed by a later phase of metabolic stabilization. These results underscore the liver’s critical role in adapting to CSD and provide insights into the metabolic adjustments that maintain glucose homeostasis under prolonged stress conditions.

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Adaptations in hepatic glucose metabolism after chronic social defeat stress in mice

Meijboom,

Hasch,

Ruiz de Azua

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

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Sub-chronic and mild social defeat stress exposure to C57BL/6J mice increases visceral fat mass and causes accumulation of cholesterol and bile acids in the liver

Cited by 1 publication

References 54 publications

Adaptations in hepatic glucose metabolism after chronic social defeat stress in mice

Adaptations in hepatic glucose metabolism after chronic social defeat stress in mice

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