Sub-chronic exposure to carbendazim induces biochemical and hematological alterations in male goats

Abstract

The present investigation reports the effect of repeated (90 days) administration of carbendazim on the biochemical and hematological parameters in male goats. Carbendazim administered orally at a daily dose of 50 mg kg À1 body weight for 90 consecutive days resulted in increased plasma concentration of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), creatinine and albumin, while alkaline phosphatase (ALP) and glucose levels were decreased. Decrease in total leukocyte (TLC) and neutrophil count and increase in lymphocyte count was observed in the treatment group. The findings of the present investigation indicate that sub-chronic exposure to carbendazim in male goats causes hepatic and slight kidney dysfunctions.

Protective Effect of <i>Gingo biloba</i> Extract on Carbendazim-Induced Hepatotoxicity in Albino Rats

“…An increase in Alt and AST was observed in sera of rats exposed to carbendazim. In accordance with this result, Waghe et al 2013 [28] reported that carbendazim administered orally to male goat at a daily dose of 50 mg·kg −1 body weight for 90 consecutive days resulted in increased plasma concentration of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), creatinine and albumin, while alkaline phosphatase (ALP) and glucose levels were decreased. It was reported that transaminases were considered to be a more sensitive measure in evaluating liver function and damage.…”