for their ability to teach, inspire and motivate. The technicians, Leonardo and Marcio, for the partnership. Friends and students of the university, for the daily friendship and research support. My friend Anis, for a year of high-level knowledge sharing, learning and the Chapter 6 full of experience. Petrobras and CNPq for the financial support. My husband Flavio, who with love and affection also dived in this intense project. My sons Miguel and Matheus, who were born and in the middle of these pages, grew up. They gave me maturity. Revealed my ability. In the form of a hug, a smile, at the end of the day, they reloaded everything I needed. And lastly my life references, my parents and my sister, who with love and joy, taught me how to overcome harmoniously the difficulties day by day.