Sub‐Micrometer Vaterite Containers: Synthesis, Substance Loading, and Release

Parakhonskiy, Bogdan; Haase, Andrea; Antolini, R.

doi:10.1002/anie.201104316

Cited by 188 publications

(156 citation statements)

References 34 publications

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“…Recently, size control of spherical vaterite particles in the range from 10 down to 0.4 μm (Fig. 2a) has been achieved in a mixture of water and ethylene glycol (EG) [50]. The presence of EG during synthesis of CaCO 3 particles diminishes the molecular diffusion, reduces the rate and the probability of nucleation, which leads to stabilization of the particles.…”

Section: Calcium Carbonate (Caco 3 )mentioning

confidence: 99%

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Colloidal micro- and nano-particles as templates for polyelectrolyte multilayer capsules

Parakhonskiy

Yashchenok

Konrad

et al. 2014

Advances in Colloid and Interface Science

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110

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Colloidal particles play an important role in various areas of material and pharmaceutical sciences, biotechnology, and biomedicine. In this overview we describe micro-and nano-particles used for the preparation of polyelectrolyte multilayer capsules and as drug delivery vehicles. An essential feature of polyelectrolyte multilayer capsule preparations is the ability to adsorb polymeric layers onto colloidal particles or templates followed by dissolution of these templates. The choice of the template is determined by various physico-chemical conditions: solvent needed for dissolution, porosity, aggregation tendency, as well as release of materials from capsules. Historically, the first templates were based on melamine formaldehyde, later evolving towards more elaborate materials such as silica and calcium carbonate. Their advantages and disadvantages are discussed here in comparison to non-particulate templates such as red blood cells. Further steps in this area include development of anisotropic particles, which themselves can serve as delivery carriers. We provide insights into application of particles as drug delivery carriers in comparison to microcapsules templated on them.

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Section: Calcium Carbonate (Caco 3 )mentioning

confidence: 99%

“…In contrast to smooth particles, porous ones, for example CaCO 3 , are not stable in aqueous solution or during extended steps of synthesis, and they transform to the more stable calcite structure [50]. Early studies have demonstrated the influence of aqueous and PBS buffer on CaCO 3 morphology (Fig.…”

Section: Stability and Decomposition Of Particlesmentioning

confidence: 99%

Colloidal micro- and nano-particles as templates for polyelectrolyte multilayer capsules

Parakhonskiy

Yashchenok

Konrad

et al. 2014

Advances in Colloid and Interface Science

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110

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“…Nevertheless, we expect that the density of vaterite is less than that of calcite, given the preponderance of experimental measurements. On this basis, those models proposed with densities the same as, or greater than, calcite (2.72 g/cm 3 ) seem unlikely candidates for vaterite. To our knowledge, neutron diffraction has never been used to study vaterite, yet it offers several advantages that suggest that this technique may provide empirical weight to one or more of the list of proposed structural models.…”

mentioning

confidence: 98%

“…For instance, vaterite's greater ability to dissolve in body fluids compared to other polymorphs of CaCO 3 makes it desirable for manufacturing nanocapsules for delivering drugs at the cellular level 3 . Despite the realized and potential importance of vaterite to humans, some of the most basic facts about this compound such as its crystalline structure have challenged researchers.…”

mentioning

confidence: 99%

Empirically Testing Vaterite Structural Models Using Neutron Diffraction and Thermal Analysis

Chakoumakos

Pracheil

Koenigs

et al. 2016

Geological Society of America Abstracts With Programs

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Otoliths, calcium carbonate (CaCO 3 ) ear bones, are among the most commonly used age and growth structures of fishes. Most fish otoliths are comprised of the most dense CaCO 3 polymorph, aragonite. Sturgeon otoliths, in contrast, have been characterized as the rare and structurally enigmatic polymorph, vaterite-a metastable polymorph of CaCO 3 . Vaterite is an important material ranging from biomedical to personal care applications although its crystal structure is highly debated. We characterized the structure of Lake Sturgeon otoliths using thermal analysis and neutron powder diffraction, which is used non-destructively. We confirmed that while Lake Sturgeon otoliths are primarily composed of vaterite, they also contain the denser CaCO 3 polymorph, calcite. For the vaterite fraction, neutron diffraction data provide enhanced discrimination of the carbonate group compared to x-ray diffraction data, owing to the different relative neutron scattering lengths, and thus offer the opportunity to uniquely test the more than one dozen crystal structural models that have been proposed for vaterite. Of those, space group P6 5 22 model, a = 7.1443(4)Å, c = 25.350(4)Å, V = 1121.5(2) Å 3 provides the best fit to the neutron powder diffraction data, and allows for a structure refinement using rigid carbonate groups.Vaterite, a metastable polymorph of calcium carbonate (CaCO 3 ) 1 is of substantial interest as a naturally occurring biomaterial, and for its use as an additive in various consumer products ranging from paper and coatings to plastic and elastomer reinforcement to food supplements, oral hygiene aids, and cosmetics 2 . For instance, vaterite's greater ability to dissolve in body fluids compared to other polymorphs of CaCO 3 makes it desirable for manufacturing nanocapsules for delivering drugs at the cellular level 3 . Despite the realized and potential importance of vaterite to humans, some of the most basic facts about this compound such as its crystalline structure have challenged researchers. Currently, more than a dozen crystal structure models have been proposed with little weight favoring one over the others 1 . Many basic properties of vaterite are unresolved due in part to the rarity of naturally occurring vaterite. Naturally occurring vaterite structures include human gallstones and portions of fish ear bones, or otoliths, from primitive fishes such as sturgeons 4 or sporadically from more modern fishes such as salmon and trout, and are potentially formed in response to physiological stress, especially thermal stress 5 and captive rearing 6,7 . In fact, only a few reliable sources of biogenic vaterite exist for study including sea squirt spicules 8,9 and otoliths of sturgeons, but only rarely those of other fish or animals. The ability of making biogenic vaterite has apparently been retained through evolution in some fish such as salmonids because these fishes sometimes have vaterite patches in their otoliths 4,10 , but sturgeons are really the sole reliable source of vaterite from fish otoliths. Unlike...

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“…Similar to mesoporous silica, mesoporous calcium carbonate (CaCO 3 ) is also a promising oral drug carrier due to its porous structure, relatively high surface area, ability to protect encapsulated components, excellent biocompatibility, and biodegradability. [14][15][16] In addition, chemical decomposition of calcium carbonate is fast under acidic conditions in the stomach by the liberation of carbon dioxide. Furthermore, the synthesis of mesoporous calcium carbonate is cost-effective and does not need the use of any toxic surfactants.…”

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confidence: 99%

Hydroxypropyl-β-cyclodextrin functionalized calcium carbonate microparticles as a potential carrier for enhancing oral delivery of water-insoluble drugs

Zhang¹,

Zhu²,

Lin³

et al. 2015

IJN

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The objective of the present study was to demonstrate that a novel hydroxypropyl-β-cyclodextrin functionalized calcium carbonate (HP-β-CD/CC) based amorphous solid dispersion (ASD) can be used to increase the solubility and oral bioavailability of water-insoluble drugs. Irbesartan (IRB) was selected as a model compound and loaded into the nanoporous HP-β-CD/CC matrix using an immersion method. The IRB-loaded HP-β-CD/CC formulation was characterized by various analytical techniques, such as specific surface area analysis, scanning electron microscopy (SEM), dynamic light scattering (DLS), powder X-ray diffraction (PXRD), and differential scanning calorimetry (DSC). Analyses with PXRD and DSC confirmed that IRB was fully converted into the amorphous form in the nanopores of HP-β-CD/CC. From the solubility and dissolution tests, it was observed that the aqueous solubility and dissolution rate of IRB-loaded HP-β-CD/CC were increased significantly compared with those of pure IRB and IRB-loaded mesoporous silica. Likewise, the IRB-loaded HP-β-CD/CC formulation exhibited better absorption compared with that of the commercially available IRB capsules in beagle dogs. The mean peak plasma concentration ( C max ) and the area under the mean plasma concentration–time curve (AUC [0→48] ) of IRB-loaded HP-β-CD/CC were 1.56- and 1.52-fold higher than that of the commercial product, respectively. Furthermore, the IRB-loaded HP-β-CD/CC formulation exhibited excellent stability against re-crystallization. These results clearly demonstrate that HP-β-CD/CC based porous ASD is a promising formulation approach to improve the aqueous solubility and the in vivo absorption performance of a water-insoluble compound like IRB.

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Sub‐Micrometer Vaterite Containers: Synthesis, Substance Loading, and Release

Cited by 188 publications

References 34 publications

Colloidal micro- and nano-particles as templates for polyelectrolyte multilayer capsules

Colloidal micro- and nano-particles as templates for polyelectrolyte multilayer capsules

Empirically Testing Vaterite Structural Models Using Neutron Diffraction and Thermal Analysis

Hydroxypropyl-β-cyclodextrin functionalized calcium carbonate microparticles as a potential carrier for enhancing oral delivery of water-insoluble drugs

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Sub‐Micrometer Vaterite Containers: Synthesis, Substance Loading, and Release

Cited by 188 publications

References 34 publications

Colloidal micro- and nano-particles as templates for polyelectrolyte multilayer capsules

Colloidal micro- and nano-particles as templates for polyelectrolyte multilayer capsules

Empirically Testing Vaterite Structural Models Using Neutron Diffraction and Thermal Analysis

Hydroxypropyl-&beta;-cyclodextrin functionalized calcium carbonate microparticles as a potential carrier for enhancing oral delivery of water-insoluble drugs

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Product

Resources

About

Hydroxypropyl-β-cyclodextrin functionalized calcium carbonate microparticles as a potential carrier for enhancing oral delivery of water-insoluble drugs