Sub-millisecond 2D MRI of the vocal fold oscillation using single-point imaging with rapid encoding

Abstract

Objective The slow spatial encoding of MRI has precluded its application to rapid physiologic motion in the past. The purpose of this study is to introduce a new fast acquisition method and to demonstrate feasibility of encoding rapid two-dimensional motion of human vocal folds with sub-millisecond resolution. Method In our previous work, we achieved high temporal resolution by applying a rapidly switched phase encoding gradient along the direction of motion. In this work, we extend phase encoding to the second image direction by using single-point imaging with rapid encoding (SPIRE) to image the two-dimensional vocal fold oscillation in the coronal view. Image data were gated using electroglottography (EGG) and motion corrected. An iterative reconstruction with a total variation (TV) constraint was used and the sequence was also simulated using a motion phantom. Results Dynamic images of the vocal folds during phonation at pitches of 150 and 165 Hz were acquired in two volunteers and the periodic motion of the vocal folds at a temporal resolution of about 600 µs was shown. The simulations emphasize the necessity of SPIRE for two-dimensional motion encoding. Discussion SPIRE is a new MRI method to image rapidly oscillating structures and for the first time provides dynamic images of the vocal folds oscillations in the coronal plane.

Experimenting ‘In Vivo’ with Dynamic Glottal Parameters: Methodological Issues, Technical Tips & Tricks and Preventable Pitfalls

“…Another current and promising research field in VF imaging is dynamic 2D magnetic resonance. Fischer et al [53] succeeded in obtaining dynamic images of the periodic motion of the vocal folds during phonation in vivo at pitches of 150 and 165 Hz, with a temporal resolution of about 600 µs. The dynamic image information correlates well with the oscillation phases from the EGGsignal, and the open and closed phase can be clearly distinguished.…”