“…The extent of the sub-Tenon's space, as defined by Tenon's capsule (or orbital fascia), limits the area of cross-linking to this space, favoring uniform distribution across the posterior sclera, which is the location of desired effect. 14 Thus, in lieu of such concerns and potential benefits, the development of an alternative cross-linking approach that could avoid the use of UV-A light, and avoid epithelial removal (for the cornea), is less cytotoxic and could provide crosslinking to the posterior sclera without requiring a light source, and could be of significant interest to the field of ophthalmic therapeutics. This has prompted a search for candidate chemical cross-linking agents that could be used for therapeutic stabilization of either the cornea and/or sclera.…”