2023
DOI: 10.21203/rs.3.rs-3750450/v1
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Sub-Zero Non-Freezing of Vascularized Composite Allografts Preservation in Rodents

Irina Filz von Reiterdank,
Pierre Tawa,
Yanis Berkane
et al.

Abstract: Ischemia is a major limiting factor in Vascularized Composite Allotransplantation (VCA) as irreversible muscular injury can occur after as early as 4-6 hours of static cold storage (SCS). Organ preservation technologies have led to the development of storage protocols extending rat liver ex vivo preservation up to 4 days. Development of such a protocol for VCAs has the added challenge of inherent ice nucleating factors of the graft, therefore this study focused on developing a robust protocol for VCA supercool… Show more

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