Subacute and Recurrent Transient Perivascular Inflammation of the Carotid Artery (TIPIC syndrome) and Supraclavicular Lymphadenopathy Associated with Ipsilateral Intramuscular m-RNA COVID-19 Vaccine

Ulus, Sıla; Denizoglu, Nurper; Akarçay, Mustafa

doi:10.36519/idcm.2022.126

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Only one other case of TIPIC syndrome after mRNA-based COVID-19 vaccination has been described recently [ 13 ]. In this case, a 39-year-old patient presented with ipsilateral neck pain, which debuted one week after the first vaccination with an mRNA-based Pfizer-BioNTech COVID-19 (BNT162b2) vaccine and later relapsed after a second vaccination with the same substance.…”

Section: Discussionmentioning

confidence: 99%

Relapsing TIPIC Syndrome after Administration of an mRNA-Based COVID-19 Vaccine

Sandu,

Weisser,

Krämer

et al. 2023

Case Reports in Vascular Medicine

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Reported vascular complications following mRNA-based COVID-19 vaccines are consisting of myocarditis, cerebral venous thrombosis, cerebral vascular thrombosis, and vaccine-induced thrombocytopenia. Here, we describe a case of a 49-year-old woman with left-sided pain above the middle common carotid artery (carotidynia) starting a few days after her second vaccination with an mRNA-based COVID-19 vaccine (Spikevax). Imaging was indicative of transient perivascular inflammation of the carotid artery (TIPIC) syndrome. The diagnostic workup for other immunologically mediated diseases was negative. The inflammation subsided after a course of prednisone and aspirin, and clinical symptoms vanished, but later mildly relapsed in the context of a viral upper respiratory tract infection other than SARS-CoV-2. Carotidynia because of TIPIC syndrome may present as an immunogenic side effect of the newly developed mRNA-based vaccinations against COVID-19. TIPIC syndrome should be considered in new-onset neck pain after vaccination.

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Section: Discussionmentioning

confidence: 99%

Relapsing TIPIC Syndrome after Administration of an mRNA-Based COVID-19 Vaccine

Sandu,

Weisser,

Krämer

et al. 2023

Case Reports in Vascular Medicine

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COVID-19 Infection Raising Suspicions of a Connection between Vascular Damage and Thrombus Formation

Kobayashi,

Furukawa,

Kasuga

et al. 2024

Intern. Med.

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Although endothelial damage has been hypothesized to be associated with coronavirus disease 2019 (COVID-19)-related cerebral infarction based on the specificity of the viral cellular invasion pathway, no case has been reported to date. We herein report a 51-year-old Japanese woman who presented with neck pain one week after COVID-19 infection. Computed tomography and magnetic resonance imaging revealed inflammation of the carotid and vertebral arteries. Ultrasonography revealed multiple flap-like structures that were assumed to be thrombi. Although the patient had no cerebral infarction, this could be an important case of vascular damage and thrombus formation in a COVID-19 patient.

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Subacute and Recurrent Transient Perivascular Inflammation of the Carotid Artery (TIPIC syndrome) and Supraclavicular Lymphadenopathy Associated with Ipsilateral Intramuscular m-RNA COVID-19 Vaccine

Abstract: We describe a case of recurrent transient perivascular inflammation of the carotid artery (TIPIC) syndrome and associated supraclavicular lymphadenopathy after ipsilateral intramuscular administration of an mRNA-based COVID-19 vaccine.

Cited by 2 publications

References 14 publications

Relapsing TIPIC Syndrome after Administration of an mRNA-Based COVID-19 Vaccine

Relapsing TIPIC Syndrome after Administration of an mRNA-Based COVID-19 Vaccine

COVID-19 Infection Raising Suspicions of a Connection between Vascular Damage and Thrombus Formation

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