Subacute aseptic meningitis as neurological manifestation of primary Sjögren's syndrome

Rossi, Rosario; Saddi, Maria Valeria

doi:10.1016/j.clineuro.2005.05.015

Cited by 38 publications

(18 citation statements)

References 11 publications

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“…Recurrent aseptic meningitis with diffuse leptomeningeal enhancement has also been reported. [187][188][189] When present, spinal cord involvement is characterized by TM or LETM. 190 Interestingly, overlap cases with NMOSD have been reported.…”

Section: Neurosarcoidosismentioning

confidence: 99%

Neuroimaging in Pediatric Autoimmune Diseases

Longoni

Banwell

2017

J Pediatr Neurol

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Magnetic resonance imaging plays an essential role in the diagnosis and management of pediatric central nervous system (CNS) autoimmune disorders. This article reviews the key clinical and conventional neuroimaging characteristics of the most frequent entities of the demyelinating disease spectrum, with a goal to inform and guide decisions in the clinical practice. We focus on acquired demyelinating syndromes and their differential diagnoses including mimics such as systemic inflammatory disorders with secondary CNS involvement. In the vast majority of disorders, no specific biomarker of disease is known and the final diagnosis is based on recognizable syndromic characteristics. Therefore, familiarity with the related neuroimaging patterns can improve a timely diagnosis of pediatric autoimmune diseases and prompt targeted therapeutic approach.

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Section: Neurosarcoidosismentioning

confidence: 99%

Neuroimaging in Pediatric Autoimmune Diseases

Longoni

Banwell

2017

J Pediatr Neurol

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“…These disorders may be recurrent, associated with other neurological abnormalities including seizures, cranial nerve palsies and coma, and respond to steroids (135)(136)(137)(138)(139)(140). The illness was protracted, but after 3 months, she had developed increased drowsiness that did not respond to plasmapharesis, and she expired 6 months after that initial hospital admission.…”

Section: Aseptic Meningoencephalitismentioning

confidence: 99%

The Neurological Manifestations of Sjögren’s Syndrome: Diagnosis and Treatment

Fox

Birnbaum

2011

Sjögren’s Syndrome

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“…pSS has been associated with lesions in cerebral white matter, which appear as T1 and T2 hypo-and/or hyper-intense signals on magnetic resonance imaging (MRI) (11). Other reports suggest that diffuse brain lesions in pSS resemble multiple sclerosis (MS) (12), lesions in the mid pons resemble central pontine myelinolysis (13), lesions in the meninx resemble sterile meningitis (14)(15)(16), lesions in the cortex and deep gray matter resemble cerebral atrophy (17), lesions in the spinal cord resemble transverse myelitis, and the involvement of multiple consecutive spinal cord segments resemble chronic progressive myelopathy (18,19).…”

Section: Introductionmentioning

confidence: 99%

Resting-state fMRI in primary Sjögren syndrome

et al. 2018

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Background The involvement of the central nervous system in primary Sjögren syndrome (pSS) remains controversial. Functional magnetic resonance imaging (fMRI) is a relatively new method that can be applied to investigate the heterogeneity of central nervous system (CNS) involvement in pSS patients through regional homogeneity (ReHo) analysis. Purpose To collect data from pSS patients and healthy controls, and use ReHo analysis to elucidate the neurobiological mechanism of CNS involvement in pSS. Material and Methods Fourteen clinically diagnosed pSS patients and 14 age- and gender-matched healthy controls underwent resting-state fMRI. The data were processed by ReHo analysis. The double sample t-test was used to compare ReHo data between groups. Results Compared to controls, pSS patients had significantly increased ReHo values in the right cerebrum, left limbic lobe, right middle temporal gyrus, and the inferior parietal lobe. However, ReHo values significantly decreased in the right lingual gyrus, left cuneiform lobe, left superior occipital gyrus, bilateral middle occipital gyrus, and the fronto-parietal junction area ( P < 0.01, clusters ≥ 50 voxels). Conclusion This study demonstrates the abnormal brain activity in the visual cortex and fronto-parietal junction area in pSS patients, suggesting pathological neuronal dysfunction in these regions.

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Subacute aseptic meningitis as neurological manifestation of primary Sjögren's syndrome

Cited by 38 publications

References 11 publications

Neuroimaging in Pediatric Autoimmune Diseases

Neuroimaging in Pediatric Autoimmune Diseases

The Neurological Manifestations of Sjögren’s Syndrome: Diagnosis and Treatment

Resting-state fMRI in primary Sjögren syndrome

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