2020
DOI: 10.1071/en19249
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Subacute co-exposure to low doses of ruthenium(III) changes the distribution, excretion and biological effects of silver ions in rats

Abstract: Environmental contextAlthough ruthenium is a technology-critical element used in several new industries, little is known about its environmental impact or possible human health risks. We report a toxicological evaluation of laboratory animals during co-exposure to ruthenium and silver. We identified interactions between the two elements that could lead to unwanted biological effects. AbstractRuthenium is one of the rarest metals on Earth that is classified as a technology-critical element (TCE). Silver, howeve… Show more

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Cited by 19 publications
(13 citation statements)
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“…Glutathione, a very important endogenous antioxidant molecule involved in cellular detoxification and redox homeostasis, and MDA, a key biomarker of lipid peroxidation and indicator of aging, are frequently analyzed for the evaluation of OS [42]. Previous studies have shown that the levels of glutathione can decrease, while the level of MDA can increase during the aging process [43].…”
Section: Discussionmentioning
confidence: 99%
“…Glutathione, a very important endogenous antioxidant molecule involved in cellular detoxification and redox homeostasis, and MDA, a key biomarker of lipid peroxidation and indicator of aging, are frequently analyzed for the evaluation of OS [42]. Previous studies have shown that the levels of glutathione can decrease, while the level of MDA can increase during the aging process [43].…”
Section: Discussionmentioning
confidence: 99%
“…These significant increases in the purities of total phenolics, flavonoids, flavonols, flavanols, and phenolic acids indicated the high efficiency of AB-8 macroporous resin, which could be considered as an ideal purification media. The improvement of the purity of phenolic compounds is often of great significance for the evaluation of their biological activities [ 27 ].…”
Section: Resultsmentioning
confidence: 99%
“…In order to reveal a new strategy for the prevention of oxidative stress-caused diseases, it is important to take into account that, although the health effects of phenolic compounds are supported by their powerful antioxidant activity, their influence on health will depend on the amount consumed and their bioavailability. Moreover, despite the promising potential of any compound/element/extract demonstrated in vitro, the efficacy/beneficial effects and the level of safety can only be established through in vivo toxicological studies [ 37 , 38 ]. As there are currently insufficient studies in chronic models to demonstrate the relationship between the bioavailability of phenolic compounds and their antioxidant effects, this experiment aimed to assess the relationship between in vitro and in vivo wine functionality, namely whether the in vivo antioxidant response of wines correlates with the in vitro antioxidant activity of wines.…”
Section: Introductionmentioning
confidence: 99%