Subacute Combined Degeneration of the Cord: Symptomatology and Effects of Liver Therapy

Neurogenic Bladder Revealing a Pernicious Anemia: One Case Report and Literature Review

“…Cystometric examination usually discloses the presence of an atonic bladder paralysis with impaired sense of bladder filling, very low intravesical pressure, increased bladder capacity and variable amounts of residual urine. Most observers agree that bladder neck and sphincter symptoms may disappear with treatment of the pernicious anemia [10,11,12]. As we have shown in our case the patient regained normal bladder function as regards both symptoms and cystometric findings after a few of liver therapy by vitamin B12.…”

Untitled

“…The neurologic disorders associated with pernicious anemia were well described in the literature of the late nineteenth century and the first decade of this century [1][2][3][4][5][6][7]. Certain limitations including uncertainty as to underlying diagnosis and problems in evaluating therapy are noted in previous studies.…”

Combined Cord Degeneration Without Anemia: A Case Report With Studies Bearing on the “Intrinsic Factor” of Castle

“…In the first case, the red blood cell count two days before death is given as 4,500,000 cells per cubic millimeter, hemoglobin, 90 per cent; in the second, no figures are recorded, but the statement is made, " There was no anemia." Ungley and Suzman (6), in their study of combined cord degeneration, noted six cases in which no definite anemia was present. The three patients who survived for more than two years without liver treatment had comparatively high counts, viz., 5.6, 4.45, and 3.9 millions per cu.…”

“…The prevailing view seems to be that in the absence of " ergotism, pellagra, syphilis, arteriosclerosis, and cachectic states " all patients with combined cord degeneration are in reality cases of pernicious anemia (1,2,3,4,5,6). This is supported by the recognized frequency of combined cord degeneration in pernicious anemia, by the generally accepted opinion that the neurologic signs may precede the appearance of anemia by many months or years, and by the constancy of achlorhydria in both conditions.…”