Subacute Effects of Capsaicinoids on the Distribution of White Blood Cells in Rats

Aritoshi, Shoko; Sato, Shogo; Kumazawa, Mari; Ban, Takamasa; Tanihata, Jun; Tachiyashiki, Kaoru; Imaizumi, Kazunori

doi:10.1248/jhs.56.99

Cited by 6 publications

(14 citation statements)

References 16 publications

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“…1B). 5,[23][24][25][26] Statistical Analyses --Experimental data were presented as mean ± SEM. The effects of dexamethasone on the number of WBCs were evaluated by a two-way analysis of variance (ANOVA) for repeated measures.…”

Section: Fig 1 Experimental Protocol Used In the Present Studymentioning

confidence: 99%

Acute and Subacute Effects of Dexamethasone on the Number of White Blood Cells in Rats

Ohkaru

Arai

Ohno

et al. 2010

JOURNAL OF HEALTH SCIENCE

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The purpose of this study was to elucidate the effects of dexamethasone, a synthetic glucocorticoid, on the immune system by analyzing the number of white blood cells (WBCs) over the course of hours and days of dexamethasone administration. Dexamethasone was given as either a single dosage [1.0 mg/kg body weight (BW); subcutaneous injection (s.c.)] or as a daily dosage (1.0 mg/kg BW per day; s.c.) for 10 days for the hourly and daily assessment of changes in the number of white blood cells, respectively. A single administration of dexamethasone markedly decreased the number of total WBCs, as well as the number of lymphocyte, monocyte, neutrophil and eosinophil subsets with a nadir at 8 hr post-injection. The number of these cells recovered to the control levels at 24 hr. The numbers of total WBCs, lymphocytes, monocyte, eosinophil and basophil were reduced by the daily administration of dexamethasone. However, the number of neutrophil was significantly higher at days 2 and 8 after the injection. These results suggest that glucocorticoid-mediated immunosuppressions are at least partly attributable to quantitative changes in the number of circulating WBCs.

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Section: Fig 1 Experimental Protocol Used In the Present Studymentioning

confidence: 99%

Acute and Subacute Effects of Dexamethasone on the Number of White Blood Cells in Rats

Ohkaru

Arai

Ohno

et al. 2010

JOURNAL OF HEALTH SCIENCE

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“…24,25) In the control group, an equivalent volume of AITC-free solution was administered in the same manners. 11,13,21,23) Count Analyses of Lymphocytes --According to our recent results, 11) diurnal rhythm of the number of lymphocytes in male adult rats was observed and the lowering actions of the pungent principles of hot pappers such as capsaicin and dihydrocapsaicin on the number of lymphocytes, T-lymphocyte and B-lymphocyte were observed at 3 hr after the administration. In the present study, therefore, we analyzed the number of lymphocytes at 1-4 hr after the administration of AITC.…”

Section: Methodsmentioning

confidence: 83%

“…These findings coincide with our previous results of dihydrocapsaicin-decreased numbers of lymphocytes, T-lymphocyte and B-lymphocyte. 11,12,21) We have also reported that dihydrocapsaicin decreased the number of acquired immunity cells such as lymphocytes, T-lymphocyte and B-lymphocyte without changing the number of NK cells. 11,21) These findings suggest that immunosuppressions may be induced by pungent components such as AITC and dihydrocapsaicin.…”

Section: Discussionmentioning

confidence: 89%

“…The experiment was performed with the least possible pain of discomfort to the animals. [11][12][13][20][21][22] Administration of AITC to Rats --AITC (purity 95%; Wako Pure Chem. Ind., Osaka, Japan) was dissolved in 2% ethanol and then added 10% Tween 80 and 0.9% NaCl as a vehicle to obtain 0.5% and 1.0% of AITC.…”

Section: Methodsmentioning

confidence: 99%

“…14,15) Whole blood samples were collected from the tail vein according to our routine method. 21,22) These samples were used for the count analyses of lymphocytes. The number of red blood cells (RBCs), hemoglobin concentration and hematocrit value were also analyzed.…”

Section: Methodsmentioning

confidence: 99%

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Lowering Effects of Allyl Isothiocyanate on the Number of Lymphocyte and Its Subsets in Rats

Imaizumi

Sakakibara

Sasaki

et al. 2010

JOURNAL OF HEALTH SCIENCE

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Allyl isothiocyanate-induced changes in the distribution of white blood cells in rats

et al. 2010

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-The main pungent component of wasabi (Eutrema japonica) is known to be isothiocyanate and its derivatives, volatile substances. Allyl isothiocyanate (AITC) accounts for more than half of isothiocyanate derivatives. However, there is a little information on the effects of AITC on the immune system by analyzing the number of white blood cells (WBCs) over the course of days of AITC administration. In the present study, we studied the effects of AITC (dose=20 mg/kg body weight/day for 10 days, subcutaneous: s.c.) on the number of WBCs (total WBCs, lymphocytes, monocyte, neutrophil, basophil and eosinophil) and plasma corticosterone concentrations in adult male rats. Administration of AITC decreased significantly the number of total WBCs on days 1-4 post s.c. injection by 25-27%. Administration of AITC also decreased the number of lymphocytes on days 1-10 by 21-36% and monocyte on days 1-8 by 28-78%. However, administration of AITC increased the number of neutrophil on days 8-10 by 61-112%. AITC did not change the number of eosinophil and basophil. Plasma corticosterone concentrations during the experimental period were 4.7-8.4 times significantly higher in the AITC group than in the control group, indicating that AITC induced stress-responses. The relative weights of thymus and adrenals per body weight were significantly lower and clearly higher in the AITC group than in the control group, respectively. These results suggest that AITC-mediated stress-responses are at least in part attributable to changes in the number of circulating WBCs.

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Subacute Effects of Capsaicinoids on the Distribution of White Blood Cells in Rats

Cited by 6 publications

References 16 publications

Acute and Subacute Effects of Dexamethasone on the Number of White Blood Cells in Rats

Acute and Subacute Effects of Dexamethasone on the Number of White Blood Cells in Rats

Lowering Effects of Allyl Isothiocyanate on the Number of Lymphocyte and Its Subsets in Rats

Allyl isothiocyanate-induced changes in the distribution of white blood cells in rats

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