Subacute-onset paraneoplastic autonomic neuropathy associated with prostate cancer

Muccioli, Lorenzo; Nicodemo, Marianna; Cortelli, Pietro; Guarino, Maria

doi:10.1007/s10286-020-00719-9

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…Recent studies have also found that autonomic dysfunction is associated with prostate cancer with anti-AchR antibodies. [ 14 ] Similar findings were reported in our case with thyroid carcinoma. To our knowledge, this is the first case report of anti-SOX1 abs-positive autonomic PNS with a high suspicion of papillary thyroid microcarcinoma.…”

Section: Discussionsupporting

confidence: 90%

Anti-SOX1 antibodies-positive paraneoplastic neurological syndromes caused by thyroid carcinoma: A case report

et al. 2023

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Rationale: Paraneoplastic neurological syndromes (PNSs) are a group of neurological diseases caused by distant immune effects of malignant tumors, which often occur in patients with small cell lung cancer but are not prone to occur in patients with thyroid cancer. Anti-Sry-like high mobility group box (SOX)1 antibodies (abs)-associated PNSs caused by thyroid cancer are clinically rarer. Patient concerns: A 57-year-old Chinese male patient presented with autonomic neuropathy. A thyroid biopsy revealed the diagnosis of papillary thyroid microcarcinoma. The serum anti-SOX1 abs confirmed positive. Diagnoses: A diagnosis of anti-SOX1 antibodies-positive PNS was made. Interventions: The patient received total thyroidectomy. Outcomes: After total thyroidectomy, the patient’s symptoms resolved quickly, and the serum anti-SOX1 abs test results was negative on re-examination. Lessons: Thyroid cancer can cause anti-SOX1 abs-associated PNS with only autonomic neuropathy.

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Section: Discussionsupporting

confidence: 90%