Subacute sclerosing panencephalitis after intrauterine infection

Abstract

Subacute sclerosing panencephalitis (SSPE), in the majority of cases, is caused by the wild measles virus, although there are some reports relating SSPE to vaccination. This paper presents an inborn that was infected during pregnancy by the measles virus and developed SSPE within the first year of life after a short incubation period. He progressed rapidly after a mild arrest with treatment. Subacute sclerosing panencephalitis is a fatal degenerative disease and, although it had largely disappeared because of nearly universal measles vaccination, it still remains a serious infection among children affected by human immunodeficiency virus (HIV). The lack of newer cases of SSPE occurring among normal children nowadays should not wane alertness by obstetricians and paediatricians, to recognize the risk with measles during pregnancy and the need for prevention and recognition of SSPE at an early stage. Although some references exist which report on SSPE cases related to vaccination, new work weakens the possible links between measles vaccine and SSPE. Conclusion: This report would like to stress the importance and success of reducing the SSPE problem with the aid of general measles vaccination with high coverage.

Subacute sclerosing panencephalitis

“…However, perinatal intrauterine measles infection may result in SSPE with a short onset latency and fulminant course. Dasopoulou and Covanis presented a newborn infected during pregnancy by the measles virus and developed SSPE within the first year of life after a short incubation period [92].…”

Chickenpox, Measles, and Mumps

“…There are reports of infants with prolonged presence of the measles genome in their mononuclear cells after vertical transmission of measles [453,454]. Rapidly progressive subacute sclerosing panencephalitis has also been reported after vertically acquired measles infection [455][456][457][458][459][460].…”

Rougeole chez la femme enceinte : mise au point

“…Le risque de rougeole périnatale augmente si la naissance survient dans les trois semaines qui suivent l'infection maternelle [40,41,43,44]. Quelques cas de rougeole sont rapportés dans la littérature [45][46][47][48]. Le décès est fréquent et les nouveau-nés sont à haut risque de développer une SSPE.…”