Subacute Seizure Incidence in Thrombolysis-treated Ischemic Stroke Patients

Abstract

In this cohort of tPA-treated patients, post-stroke seizures were associated with atrial fibrillation and early mortality.

Outcome and predictive factors in post-stroke seizures: A retrospective case-control study

“…We did not find a treatment effect from the rate of TPA administration between the groups (p = 0.25). Other studies have also not identified a risk for patients to develop PSS following administration of recombinant TPA [44,45]. Currently, there are no specific evidence-based guidelines for medical management of PSS or strokerelated epilepsy beyond symptomatic treatment with ASDs.…”

Estimation of seizures prevalence in ischemic strokes after thrombolytic therapy

“…Previous studies have tried determining the relation between thrombolytic treatment and post-stroke epilepsy or seizures. The overall incidence rate of seizures in patients treated with r-tPA ranges from 4% to 20% [12][13][14].…”

Epileptic manifestations in stroke patients treated with intravenous alteplase

“…Several physiopathological mechanisms can be postulated for this association, including cortical reperfusion/hyperperfusion syndrome [3], neurotoxicity and a possible epileptogenic effect of rtPA [3][4][5][6], or the survival of islands of cortical viable tissue [7]. rtPA related seizures [3,8,9] and seizure frequency in patients treated with rtPA [10,11] have been mostly described using retrospective and non-controlled case series. Furthermore, the occurrence of seizures in rtPA patients has been associated with different stroke functional outcomes [1,3,[10][11][12].…”

“…rtPA related seizures [3,8,9] and seizure frequency in patients treated with rtPA [10,11] have been mostly described using retrospective and non-controlled case series. Furthermore, the occurrence of seizures in rtPA patients has been associated with different stroke functional outcomes [1,3,[10][11][12].…”