Subacute Thyroiditis Complicating COVID-19 Infection

Henke, Katrin; Odermatt, Jonas; Ziaka, Mairi; Rudovich, Natalia

doi:10.1177/11795476231181560

Cited by 5 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conventional, thyroid scintigraphy (TS) is used, to make the differential diagnostic ( 6 ). Yet, the rise of subacute thyroiditis (SAT) during the Covid period ( 7 , 8 ), highlighted the need to limit unnecessary evaluations and reduce hospital pressures, especially since atypical forms of thyroiditis were observed after the viral infection ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Multiparametric ultrasound-based assessment of overt hyperthyroid diffuse thyroid disease

Stoian,

Borlea,

Moisa-Luca

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

IntroductionHyperthyroidismis a prevalent condition affecting global populations, with an overall prevalence of 1.2%. Our research aimed to establish a systematic diagnostic approach using multiparametric ultrasound (MPUS) to diagnose hyperthyroid diffuse thyroid disease (DTD).MethodsWe conducted a retrospective study from June 2021 to June 2023 at a specialized endocrinology center in Timisoara, Romania, enrolling subjects presenting with clinical hyperthyroidism. Using the Mach 30 Aixplorer ultrasound equipment, evaluations were performed initially in B-mode US, followed by Color Doppler and Spectral Doppler measurements, and finally, 2D Shear wave elastography (SWE).ResultsFrom the 218 patients analyzed, the diagnosis of DTD with hyperthyroidism was confirmed through biochemical assessment, subgrouping various pathologies such as subacute thyroiditis, Graves’ disease, painless thyroiditis, Hashimoto’s thyroiditis, iatrogenic, as well as healthy controls. In the first step, B-mode hypoechogenicity had an AUC of 0.951 for DTD detection. In the second step, the peak systolic velocity differentiated Graves’ disease with a median of 42.4 cm/s and an AUC of 1. Lastly, the third step consisted of SWE evaluation, revealing a mean elasticity index in the SAT subgroup significantly higher from other subgroups (p<0.001) with an AUC of 1.ConclusionOur study offers a step-by-step evaluation algorithm for DTD diagnosis, with a very good overall diagnostic performance (AUC of 0.946).

show abstract

Section: Introductionmentioning

confidence: 99%

Multiparametric ultrasound-based assessment of overt hyperthyroid diffuse thyroid disease

Stoian,

Borlea,

Moisa-Luca

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

Associations between deep venous thrombosis and thyroid diseases: a two-sample bidirectional Mendelian randomization study

Zhang,

Li,

Yang

et al. 2024

Eur J Med Res

View full text Add to dashboard Cite

Background Some previous observational studies have linked deep venous thrombosis (DVT) to thyroid diseases; however, the findings were contradictory. This study aimed to investigate whether some common thyroid diseases can cause DVT using a two-sample Mendelian randomization (MR) approach. Methods This two-sample MR study used single nucleotide polymorphisms (SNPs) identified by the FinnGen genome-wide association studies (GWAS) to be highly associated with some common thyroid diseases, including autoimmune hyperthyroidism (962 cases and 172,976 controls), subacute thyroiditis (418 cases and 187,684 controls), hypothyroidism (26,342 cases and 59,827 controls), and malignant neoplasm of the thyroid gland (989 cases and 217,803 controls. These SNPs were used as instruments. Outcome datasets for the GWAS on DVT (6,767 cases and 330,392 controls) were selected from the UK Biobank data, which was obtained from the Integrative Epidemiology Unit (IEU) open GWAS project. The inverse variance weighted (IVW), MR-Egger and weighted median methods were used to estimate the causal association between DVT and thyroid diseases. The Cochran’s Q test was used to quantify the heterogeneity of the instrumental variables (IVs). MR Pleiotropy RESidual Sum and Outlier test (MR-PRESSO) was used to detect horizontal pleiotropy. When the causal relationship was significant, bidirectional MR analysis was performed to determine any reverse causal relationships between exposures and outcomes. Results This MR study illustrated that autoimmune hyperthyroidism slightly increased the risk of DVT according to the IVW [odds ratio (OR) = 1.0009; p = 0.024] and weighted median methods [OR = 1.001; p = 0.028]. According to Cochran’s Q test, there was no evidence of heterogeneity in IVs. Additionally, MR-PRESSO did not detect horizontal pleiotropy (p = 0.972). However, no association was observed between other thyroid diseases and DVT using the IVW, weighted median, and MR-Egger regression methods. Conclusions This study revealed that autoimmune hyperthyroidism may cause DVT; however, more evidence and larger sample sizes are required to draw more precise conclusions.

show abstract

Associations between deep venous thrombosis and thyroid diseases: A two-sample bidirectional Mendelian Randomization study

Zhang,

Li,

Yang

et al. 2023

Preprint

View full text Add to dashboard Cite

Backgrounds: In some previous observational studies, deep venous thrombosis (DVT) has been linked to thyroid diseases, but the findings are debatable. This study aimed to reveal whether some common thyroid diseases can causally result in DVT using the two-sample Mendelian Randomization (MR) approach. Methods We did a two-sample MR study that chose single nucleotide polymorphisms (SNPs) which are highly associated with some common thyroid diseases from the FinnGen datasets as our instruments, including autoimmune hyperthyroidism (962 cases and 172,976 controls), subacute thyroiditis (418 cases and 187,684 controls), hypothyroidism (26,342 cases and 59,827 controls) and malignant neoplasm of thyroid gland (989 cases and 217,803 controls). Outcomes datasets about deep venous thrombosis (6,767 cases and 330,392 controls) were obtained from the IEU open GWAS project. Inverse variance weighted (IVW), MR-Egger and weighted median were used to estimate the causal association between DVT and thyroid diseases. Cochran’s Q test was used to quantify the heterogeneity of instrumental variables. We also detected horizontal pleiotropy using MR-PRESSO. When the causal relationship was significant, a bidirectional Mendelian randomization analysis was performed to determine if there were reverse causal relationships between exposures and outcomes. Results The Mendelian Randomization analysis illustrated that autoimmune hyperthyroidism slightly raised the risk of DVT in IVW method[odds ratio (OR) = 1.000891; 95% confidence interval (CI):1.0001156–1.001667; p = 0.0243]. Weighted median showed a similar association[OR = 1.000984; 95%CI: 1.0000806–1.001888; p = 0.03278]. There was no evidence of heterogeneity in instrumental variables which Cochran’s Q test showed and MR-PRESSO didn’t assumed the presence of horizontal pleiotropy (p = 0.972). However, no evidence can point out that other thyroid diseases had relationship with DVT using the IVW method, weighted median method and MR-Egger regression. Conclusion Our research found that autoimmune hyperthyroidism may cause DVT. More evidences and lager samples are needed to draw more precise conclusions.

show abstract

Subacute Thyroiditis Complicating COVID-19 Infection

Cited by 5 publications

References 25 publications

Multiparametric ultrasound-based assessment of overt hyperthyroid diffuse thyroid disease

Multiparametric ultrasound-based assessment of overt hyperthyroid diffuse thyroid disease

Associations between deep venous thrombosis and thyroid diseases: a two-sample bidirectional Mendelian randomization study

Associations between deep venous thrombosis and thyroid diseases: A two-sample bidirectional Mendelian Randomization study

Contact Info

Product

Resources

About