Subacute Toxicity Profile of the Leaves of Colocasia esculenta [L. Schott] in Albino Rats

Azubike, N.C.; Achukwu, Peter Uwadiegwu; Okwuosa, Chukwugozie N; Nwachukwu, Daniel Chukwu; Onwukwe, O. S.; Onyemelukw, A.O.

doi:10.3923/rjmp.2016.340.348

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Serum levels of enzymes such as liver amino transaminases (AST and ALT) and other enzymes such as ALP are important for the assessment of hepatotoxicity of compounds. A rise in serum levels of activity of these enzymes is often indicative of damage to the liver [16].…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Sub-acute Toxicity Profile of Vitex doniana (Sweet) Leaf Fractions on Albino Rats

Onwukwe

Ukwuani

Onyemelukwe

et al. 2020

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Aim: To evaluate the sub-acute toxicity profile of fractions of Vitex doniana using adult albino rats. Study Design: An experimental study that lasted for 28 days. Place and Duration of Study: Department of Medical Laboratory Sciences and Animal House Unit, College of Medicine, University of Nigeria Enugu Campus, between January 2019 and March 2019. Methodology: Methanol, ethyl acetate and hexane fractions of V. doniana were orally administered to 6 groups of animals at doses of 150 mg/kg and 300 mg/kg body weight for each fraction, for 28 days. At the end of the administration, the animals were sacrificed. Body weight changes, Relative Organ Weights (ROW), haematological analysis, serum biochemical assay and histopathological changes of vital organs were used to evaluate the potential toxic effects of the fractions after treatments. Results: The fractions had no adverse effects on the body weights, ROW and gross appearance of the tissues. There were no significant changes in the haematological and biochemical parameters of the treated animals compared to the controls. Histological assessment of the excised organs also showed no overt pathological changes apart from thickened alveolar septa in the lungs of the animals that received methanol and ethyl acetate fractions. Conclusion: The polar fractions of V. doniana at the doses tested did not induce any toxic changes in the treated animals.

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Section: Discussionmentioning

confidence: 99%

Assessment of the Sub-acute Toxicity Profile of Vitex doniana (Sweet) Leaf Fractions on Albino Rats

Onwukwe

Ukwuani

Onyemelukwe

et al. 2020

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Phytochemical Content and In Vitro Antimycelial Efficacy of Colocasia esculenta (L), Manihot esculenta (Crantz) and Dioscorea rotundata (Poir) Leaf Extracts on Aspergillus niger and Botryodiplodia theobromae

Ogu

2018

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TheIn Vitroefficacy of aqueous leaf extracts of common edible root crops (Colocasiaesculenta,ManihotesculentaandDioscorearotundata) were investigated againstAspergillusnigerandBotryodiplodiatheobromae. The fungi were isolated from rotten tubers of yam using antibiotic-amended potatoes dextrose agar. Graded aqueous leaf extract concentrations (25 g/L, 50 g/L and 75 g/L) of each plant were applied against each test fungi on PDA plates and their mycelial growth inhibition activities were monitored for 144 hrs. Camazeb (5 – 10 g/L), a fungicide, was used as positive control agent. The phytochemical constituents of each extracts were also analyzed using standard techniques. The patterns of antifungal activities of the extracts were concentration and pathogen dependent. The most effective mean mycelial growth inhibitions were found withD.esculentaandC.esculentaagainstB.theobromae(61.9 – 80.9 %) andA.niger(63.8 – 82.8 %), respectively. Though,M.esculentaleaf extracts generally demonstrated the least antifungal activities against both pathogens, their activities were significant at 75 g/L. The antifungal potency of bothD.esculentaandC.esculentawere comparable to Camabez (chemical fungicide), which demonstrated 100 % inhibition at both 5 and 10 g/L concentrations. Higher concentrations of saponins (5.64 - 6.71 mg/100g), tannins (4.42 – 7.23 mg/100g) and flavonoids (3.64 – 5.25 mg/100g) were detected in the extracts, and could probably be linked to the observed antifungal activities. Findings from this study showed thatD.esculenta,C.esculentaandM.esculentaposses bioactive molecules that could be exploited in the bio-control of phyto-pathogens of tubers crops, which are the main staple food in most tropical countries.

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Subacute Toxicity Profile of the Leaves of Colocasia esculenta [L. Schott] in Albino Rats

Cited by 2 publications

References 20 publications

Assessment of the Sub-acute Toxicity Profile of Vitex doniana (Sweet) Leaf Fractions on Albino Rats

Assessment of the Sub-acute Toxicity Profile of Vitex doniana (Sweet) Leaf Fractions on Albino Rats

Phytochemical Content and <i>In Vitro</i> Antimycelial Efficacy of <i>Colocasia esculenta</i> (L), <i>Manihot esculenta</i> (Crantz) and <i>Dioscorea rotundata</i> (Poir) Leaf Extracts on <i>Aspergillus niger</i> and <i>Botryodiplodia theobromae</i>

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