Subacute toxicological examination of Dithane M-45

Szépvölgyi, J.; Nagy, Katalin; SajgónéVukán, K.; Regöly-Mérei, Andrea; Soós, Katalin; Tóth, Katalin; Pintér, A; Antal, M.

doi:10.1016/0278-6915(89)90049-5

Cited by 8 publications

(4 citation statements)

References 14 publications

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“…The renal tubules as well as the glomeruli were affected. Similarly, Szepvolgyi et al (1989) reported that when male and female rats were exposed to mancozeb, the kidney showed tubular dilation, necrosis, and congestion of blood vessels and the liver showed centrilobular necrosis with extramedulary hemopoiesis. Inflammatory cells were observed in the interstitial tissue of kidney of metiram‐treated mice.…”

Section: Discussionmentioning

confidence: 88%

Metiram‐induced nephrotoxicity in albino mice: Effect of licorice aqueous extract

Sakr

El-Kenawy

El-Sahra

2011

Environmental Toxicology

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The present study was designed to estimate the effect of aqueous extract of licorice on metiram toxicity in mice. Treating mice with metiram at a dose level of [1/2] LD(50) daily for 3 weeks induced many histological changes in the kidney cortex. The renal tubules lost their characteristic appearance and their lining epithelial cells were degenerated. The glomeruli were atrophied and the renal blood vessels were congested. The intertubular spaces infiltrated by inflammatory leukocytic cells. Metiram caused an increase in proliferating cell nuclear antigen (PCNA) expression in nuclei of tubular epithelial cells. Metiram also caused marked elevation in serum creatinine and blood urea nitrogen. Treating animals with metiram and licorice aqueous extract led to an improvement, in both biochemical and histopathological alterations. These results proved that licorice had an ameliorative effect against kidney injury induced by metiram and this effect may be attributed to its antioxidant activity.

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Section: Discussionmentioning

confidence: 88%

Metiram‐induced nephrotoxicity in albino mice: Effect of licorice aqueous extract

Sakr

El-Kenawy

El-Sahra

2011

Environmental Toxicology

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“…The organochlorides lindane and endosulfan seem to impair steroid synthesis in the Leydig cells (7)(8)(9). Other pesticides, such as deltamethrin, fenvalerate, methomyl, dichlorvos, dimethoate, thiram, mancozeb, and captan, have exhibited effects on spermatogenesis in animals or mutagenic effects in such genotoxicity tests on rodent germ cells as the dominant lethal test, the specific locus test, and the heritable translocation test (10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Among these pesticides the lowest occupational exposure limit for reprotoxic effects in males is 4 milligrams per kilogram of body weight per day.…”

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confidence: 99%

Semen quality and sexual hormones in greenhouse workers

Abell¹,

Ernst²,

Bonde³

2000

Scand J Work Environ Health

167

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“…Treatments indicated by asterisks are significantly different from control (two-way ANOVA followed by Dunnett's post hoc test, α = 0.05). general impairment in organisms condition since this compound is still known to induce several non-specific responses such as oxidative stress (Tsang and Trombetta, 2007) and impairments on phases I and II of organisms' detoxification systems (Lewerenz and Plass, 1984;Szépvölgyi et al, 1989;Siddiqui et al, 1991;Nebbia et al, 1993). Besides, indirect effects related to the fungicidal effects of MCZ may also have been involved.…”

Section: Discussionmentioning

confidence: 97%

Toxicity interaction between chlorpyrifos, mancozeb and soil moisture to the terrestrial isopod Porcellionides pruinosus

et al. 2016

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A main source of uncertainty currently associated with environmental risk assessment of chemicals is the poor understanding of the influence of environmental factors on the toxicity of xenobiotics. Aiming to reduce this uncertainty, here we evaluate the joint-effects of two pesticides (chlorpyrifos and mancozeb) on the terrestrial isopod Porcellionides pruinosus under different soil moisture regimes. A full factorial design, including three treatments of each pesticide and an untreated control, were performed under different soil moisture regimes: 25%, 50%, and 75% WHC. Our results showed that soil moisture had no effects on isopods survival, at the levels assessed in this experiment, neither regarding single pesticides nor mixture treatments. Additivity was always the most parsimonious result when both pesticides were present. Oppositely, both feeding activity and biomass change showed a higher sensitivity to soil moisture, with isopods generally showing worse performance when exposed to pesticides and dry or moist conditions. Most of the significant differences between soil moisture regimes were found in single pesticide treatments, yet different responses to mixtures could still be distinguished depending on the soil moisture assessed. This study shows that while soil moisture has the potential to influence the effects of the pesticide mixture itself, such effects might become less important in a context of complex combinations of stressors, as the major contribution comes from its individual interaction with each pesticide. Finally, the implications of our results are discussed in light of the current state of environmental risk assessment procedures and some future perspectives are advanced.

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Subacute toxicological examination of Dithane M-45

Cited by 8 publications

References 14 publications

Metiram‐induced nephrotoxicity in albino mice: Effect of licorice aqueous extract

Metiram‐induced nephrotoxicity in albino mice: Effect of licorice aqueous extract

Semen quality and sexual hormones in greenhouse workers

Toxicity interaction between chlorpyrifos, mancozeb and soil moisture to the terrestrial isopod Porcellionides pruinosus

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