Subarachnoid hemorrhage model in the rat: Modification of the endovascular filament model

A new percutaneous model of Subarachnoid Haemorrhage in rats

“…The reported mortality rate in our model is similar to that of other studies using the intracisternal injection model, and it is definitely less than that observed in the vascular puncture or prechiasmal injection models (Barry et al, 1979;Prunell et al, 2003;Nikaido et al, 2004;Park et al, 2008). It was found that the cisterna magna injection models manage the degree of bleeding better, and cause less disruption to the cerebral homoeostasis (Prunell et al, 2004).…”

“…This ranges from 25 to 50% (Barry et al, 1979;Kader et al, 1990;Bederson et al, 1995;Schwartz et al, 2000;Ostrowski et al, 2006). There have been various attempts to improve the technique, for example by using filaments with a smaller diameter, which have managed to lower mortality rates from 48% to 19% (Park et al, 2008). However, different studies show that mortality is almost double in vascular puncture models (Prunell et al, 2003;Lee et al, 2009).…”

“…Some authors believe that SAH is obtained when a rise in intracranial pressure is detected (Veelken et al, 1995). Subsequent studies have observed that only 48% of the animals subjected to the vascular puncture procedure were verified as presenting SAH (Park et al, 2008).…”

Curcumin mitigates cerebral vasospasm and early brain injury following subarachnoid hemorrhage via inhibiting cerebral inflammation

“…Including prechiasmatic cistern injection model, common mortality of experimental SAH rats were various from 9% to 100% (Gules, Satoh, Clower, Nanda, & Zhang, 2002; Lee, Huang, Keep, & Sagher, 2008; Lee, Sagher, Keep, Hua, & Xi, 2009; Park et al., 2008; Prunell, Mathiesen, & Svendgaard, 2002). In present study, the mortality of SAH and VEH group were 25% and 22%, respectively, which were similar to other studies using this injection model (Boettinger et al., 2017; Dou et al., 2017).…”

Argon: A Noble Foe for Subarachnoid Hemorrhage*

“…Another potential confounder of the current study is that it used two different methods of induction of SAH, namely the "classic" filament suture method and a "modified" wire filament method, which the authors [12] and others [13] have shown to have differing rates of mortality. The data for the two models were included in balanced proportions, and are combined in the figures and survival analysis.…”