Subcallosal Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression

Lozano, Andrés M.; Mayberg, Helen S.; Giacobbe, Peter; Hamani, Clement; Craddock, R. Cameron; Kennedy, Sidney H.

doi:10.1016/j.biopsych.2008.05.034

Cited by 902 publications

(527 citation statements)

References 23 publications

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“…DBS of the vALIC or STN reduces excessive frontostriatal activity and connectivity, especially in ventral frontostriatal pathways. These effects are relevant for the pathophysiology of OCD, but also for mood disorders (Lozano et al 2008;Mayberg et al, 2005), addiction, and Tourette's syndrome (Cheng et al, 2014;Worbe et al, 2015). In addition, DBS increases serotonin levels in frontal areas and stabilizes dopamine levels in the striatum.…”

Section: Mechanisms Of Dbs For Ocdmentioning

confidence: 99%

“…Mayberg et al (2005) were the first to demonstrate that 6 months of open SCC DBS resulted in at least 50% reduction on the HDRS in four out of six TRD patients. In a larger open followup trial with 20 TRD patients, including these first six patients, SCC DBS resulted in a 33% remission rate (defined as 50% reduction on HDRS) at 1-year follow-up (Lozano et al, 2008) and 43% at 3 years or last follow-up (up to 6 years) (Kennedy et al, 2011). Two other open-label trials with DBS of the SCC for TRD have been published by the same research group, including 21 and 17 new patients (Holtzheimer, 2012;Lozano et al, 2012).…”

Section: Mood Disordersmentioning

confidence: 99%

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The application of deep brain stimulation in the treatment of psychiatric disorders

Graat

Figee

Denys

2017

International Review of Psychiatry

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Deep brain stimulation (DBS) is a last-resort treatment for neurological and psychiatric disorders that are refractory to standard treatment. Over the last decades, the progress of DBS in psychiatry has been slower than in neurology, in part owing to the heterogenic symptomatology and complex neuroanatomy of psychiatric disorders. However, for obsessive-compulsive disorder (OCD) DBS is now an accepted treatment. This study first reviews clinical outcomes and mechanisms of DBS for OCD, and then discusses these results in an overview of current and future psychiatric applications, including DBS for mood disorders, Tourette's syndrome, addiction, anorexia nervosa, autism, schizophrenia, and anxiety disorders. In addition, it will focus on novel techniques that may enhance the application of DBS in psychiatry.ARTICLE HISTORY

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Section: Mechanisms Of Dbs For Ocdmentioning

confidence: 99%

Section: Mood Disordersmentioning

confidence: 99%

The application of deep brain stimulation in the treatment of psychiatric disorders

Graat

Figee

Denys

2017

International Review of Psychiatry

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“…A 2008 study of 20 patients with treatment-resistant depression suggested that, barely six months after surgery, more than 50% had responded to DBS of the cingulate gyrus and around 35% met the criteria for being in remission -benefits that were largely maintained at 12 months (ref. 2).…”

Section: Many Researchers Believe That Embryonic Stem Cells Have Potementioning

confidence: 99%

Treatment frontiers

Smith

2010

Nature

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“…Deep brain stimulation (DBS) of the subgenual cingulate gyrus (SCG) can be effective at alleviating depression symptoms in patients who are otherwise treatment-resistant (Mayberg et al, 2005;Lozano et al, 2008). Previous experiments from our lab have found that DBS applied to the rodent ventral medial prefrontal cortex (vmPFC) can also induce antidepressant-like effects (Hamani et al, 2010(Hamani et al, , 2012(Hamani et al, , 2014).…”

Section: Introductionmentioning

confidence: 99%

Chronic deep brain stimulation of the rat ventral medial prefrontal cortex disrupts hippocampal–prefrontal coherence

Insel

Pilkiw

Nóbrega

et al. 2015

Experimental Neurology

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Deep brain stimulation (DBS) of the subgenual cingulate gyrus (SCG) has been used to treat patients with treatment-resistant depression. As in humans, DBS applied to the ventromedial prefrontal cortex of rats induces antidepressant-like responses. Physiological interactions between structures that play a role in depression and antidepressant treatment are still unknown. The present study examined the effect of DBS on inter-region communication by measuring the coherence of local field potentials in the rat infralimbic cortex (IL; homologue of the SCG) and one of its major afferents, the ventral hippocampus (VH). Rats received daily IL DBS treatment (100 μA, 90 μs, 130 Hz; 8 h/day). Recordings were conducted in unrestrained, behaving animals on the day before treatment, after 1 and 10 days of treatment, and 10 days stimulation offset. VH-IL coherence in the 2-4 Hz range was reduced in DBS-treated animals compared with shams after 10 days, but not after only 1 day of treatment. No effect of DBS was observed in the 6-10 Hz (theta) range, where coherence was generally high and could be further evoked with a loud auditory stimulus. Finally, coherence was not affected by fluoxetine (10 mg/kg), suggesting that the effects of DBS were not likely mediated by increased serotonin levels. While these data support the hypothesis that DBS disrupts communication between regions important for expectation-based control of emotion, they also suggest that lasting physiological effects require many days of treatment and, furthermore, may be specific to lower-frequency patterns, the nature and scope of which await further investigation.☆ NI, MP and CH designed the experiments; NI and MP performed the experiments; NI analyzed the data; NI, JN, WDH, KT, and CH wrote the paper.

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Subcallosal Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression

Cited by 902 publications

References 23 publications

The application of deep brain stimulation in the treatment of psychiatric disorders

The application of deep brain stimulation in the treatment of psychiatric disorders

Treatment frontiers

Chronic deep brain stimulation of the rat ventral medial prefrontal cortex disrupts hippocampal–prefrontal coherence

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