Subcellular anti-atherosclerotic therapy

Ryabova, Anastasia V.; Romanishkin, I.D.; Skobeltsin, A S; Москалев, А. С.; Makarov, Vladimir; Loschenov, Victor B.; Nikiforov, Nikita G.; Собенин, И.А.; Orekhov, Alexander N.

doi:10.20517/2574-1209.2019.10

2019

DOI: 10.20517/2574-1209.2019.10

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Subcellular anti-atherosclerotic therapy

Anastasia V. Ryabova¹,

I.D. Romanishkin²,

A S Skobeltsin³

et al.

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2023

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Effect of 5-aminolevulinic Acid on Mitochondrial Activity

Markina,

Markin,

Kirichenko

et al. 2023

Front. Biosci. (Schol Ed)

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Background: Mitochondrial dysfunction is considered an important mechanism in the pathogenesis of various diseases. Therefore, mitochondria are currently being considered as subjects for targeted therapies, particularly, phototherapy using 5-aminolevulinic acid. This study aimed to investigate the activity of mitochondria in cells with different mutation loads. Materials and Methods: The study was conducted using 11 cybrid lines obtained from the THP-1 cell line (a human monocytic leukemia cell line) and platelets of patients with different mitochondrial mutations. Results: Our results illustrate that 5-aminolevulinic acid was metabolized equally in all cell lines, however, there was a significant decrease in mitochondrial potential, which differed among lines. Conclusions: The results of this study can be used to develop a personalized therapeutic approach based on different mitochondrial activities.

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Effect of 5-aminolevulinic Acid on Mitochondrial Activity

Markina,

Markin,

Kirichenko

et al. 2023

Front. Biosci. (Schol Ed)

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show abstract

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Subcellular anti-atherosclerotic therapy

Cited by 1 publication

References 5 publications

Effect of 5-aminolevulinic Acid on Mitochondrial Activity

Effect of 5-aminolevulinic Acid on Mitochondrial Activity

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