Subchondral bone in osteoarthritis: association between MRI texture analysis and histomorphometry

Mackay, James; Murray, Philip J.; Kasmai, Bahman; Johnson, Glyn; Donell, Simon; Toms, Andoni P.

doi:10.1016/j.joca.2016.12.011

Cited by 35 publications

(27 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, the neridronate group exhibited a significant decrease in bone marrow lesions evaluated by MRI, 49 suggesting a possible structural effect based on the hypothesis that altered bone metabolism plays a role in the pathogenesis of OA. [50][51][52][53] …”

Section: Osteoarthritismentioning

confidence: 99%

Neridronate: From Experimental Data to Clinical Use

Corrado

Colìa

Cantatore

2017

Clinical Medicine Insights: Therapeutics

View full text Add to dashboard Cite

Neridronate is an amino-bisphosphonate that has been officially approved as a treatment for osteogenesis imperfecta, Paget’s disease of bone and type I complex regional pain syndrome in Italy. Neridronate is administered either intravenously or intramuscularly; thus, it represents a valid option for both cases with contraindications to the use of oral bisphosphonates and cases with contraindications or an inability to receive an intravenous administration of these drugs. Furthermore, although the official authorized use of neridronate is limited to only 3 bone diseases, many experimental and clinical studies support the rationale for its use and provide evidence of its effectiveness in other pathologic bone conditions that are characterized by altered bone remodelling.

show abstract

Section: Osteoarthritismentioning

confidence: 99%

Neridronate: From Experimental Data to Clinical Use

Corrado

Colìa

Cantatore

2017

Clinical Medicine Insights: Therapeutics

View full text Add to dashboard Cite

show abstract

“…One disadvantage of MRI TA is that it is not always clear what the biological or structural correlates of individual texture features are, despite previous demonstration of association with histomorphometry [ 11 ]. However, as has been shown by the use of texture analysis in imaging applications other than assessment of subchondral bone, this lack of correspondence to an underlying structural ‘ground-truth’ does not preclude the use of this method to improve our understanding of the underlying disease process [ 27 – 29 ].…”

Section: Discussionmentioning

confidence: 99%

“…The technique has been shown to be reproducible and able to distinguish subjects at different stages of OA from healthy subjects [ 9 ]. Moreover, texture features have shown an improved ability to discriminate between knees with and without OA when compared to microarchitectural analysis and are significantly associated with histomorphometry [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Association of subchondral bone texture on magnetic resonance imaging with radiographic knee osteoarthritis progression: data from the Osteoarthritis Initiative Bone Ancillary Study

et al. 2018

View full text Add to dashboard Cite

ObjectivesTo assess whether initial or 12–18-month change in magnetic resonance imaging (MRI) subchondral bone texture is predictive of radiographic knee osteoarthritis (OA) progression over 36 months.MethodsThis was a nested case-control study including 122 knees/122 participants in the Osteoarthritis Initiative (OAI) Bone Ancillary Study, who underwent MRI optimised for subchondral bone assessment at either the 30- or 36-month and 48-month OAI visits. Case knees (n = 61) had radiographic OA progression between the 36- and 72-month OAI visits, defined as ≥ 0.7 mm minimum medial tibiofemoral radiographic joint space (minJSW) loss. Control knees (n = 61) without radiographic OA progression were matched (1:1) to cases for age, sex, body mass index and initial medial minJSW. Texture analysis was performed on the medial femoral and tibial subchondral bone. We assessed the association of texture features with radiographic progression by creating a composite texture score using penalised logistic regression and calculating odds ratios. We evaluated the predictive performance of texture features for predicting radiographic progression using c-statistics.ResultsInitial (odds ratio [95% confidence interval] = 2.13 [1.41–3.40]) and 12– 18-month change (3.76 [2.04–7.82]) texture scores were significantly associated with radiographic OA progression. Combinations of texture features were significant predictors of radiographic progression using initial (c-statistic [95% confidence interval] = 0.65 [0.64–0.65], p = 0.003) and 12–18-month change (0.68 [0.68-0.68], p < 0.001) data.ConclusionsInitial and 12–18-month changes in MRI subchondral bone texture score were significantly associated with radiographic progression at 36 months, with better predictive performance for 12–18-month change in texture. These results suggest that texture analysis may be a useful biomarker of subchondral bone in OA.Key Points • Subchondral bone MRI texture analysis is a promising knee osteoarthritis imaging biomarker. • In this study, subchondral bone texture was associated with knee osteoarthritis progression. • This demonstrates predictive and concurrent validity of MRI subchondral bone texture analysis. • This method may be useful in clinical trials with interventions targeting bone. Electronic supplementary materialThe online version of this article (10.1007/s00330-018-5444-9) contains supplementary material, which is available to authorized users.

show abstract

“…Although radiomics is used comprehensively for cancer studies, it is applicable for bone diseases management such as osteoporosis diagnosis and therapy response prediction and assessment. Previous studies have identi ed that radiomics features extracted from computed tomography (CT), magnetic resonance imaging (MRI) and radiology images could be used for bone diseases management (9,10). In our previous study, we showed the feasibility of radiomics features extracted from DXA images to classify osteoporosis and osteopenia patients from normal ones (11).…”

Section: Introductionmentioning

confidence: 97%

Test–Retest Reproducibility Analysis of Bone Mineral Densitometry Radiomics Features

Qasempour

Akhash

Shiri³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Radiomics features reproducibility assessment is a critical issue in imaging biomarker development era. In the present study, we aimed to assess test–retest reproducibility analysis of bone mineral densitometry (BMD) image radiomics features. Methods In this prospective research work, eighteen patients were included and were subjected to DXA BMD scans acquired within 10 min of each other under an approved protocol. Seven regions of interest (ROIs) including four lumbar spine regions (L1-L4) and three hip regions (trochanteric, inter trochanteric and neck) in both test and re-test images were segmented and 107 radiomics features from seven different feature sets were extracted. Intra-class correlation coefficient (ICC) were initially used to estimate radiomics features reproducibility. Results We showed that there is no radiomics feature with 90% < ICC < 100% in all ROIs, but there are three feature including Strength (from NGTDM feature set), SALGLE (Small Area Low Gray Level Emphasis) (from GLSZM feature set) and Busyness (from NGTDM feature set) with ICC < 70% in all eight ROIs. Shape features has features with ICC < 70%. Conclusion Our study on test–retest reproducibility analysis of bone mineral densitometry radiomics features shows radiomics features have several variations against changes of time of image acquisition. The reproducible features may be used as imaging biomarkers in the field of clinical densitometry. The results of this study may be repeated by more radiomics features and more BMD scanners as first line for bone mineral biomarker discovery.

show abstract

Subchondral bone in osteoarthritis: association between MRI texture analysis and histomorphometry

Abstract: MRI texture analysis features were significantly associated with ground-truth subchondral bone histomorphometry at the tibial plateau.

Cited by 35 publications

References 41 publications

Neridronate: From Experimental Data to Clinical Use

Neridronate: From Experimental Data to Clinical Use

Association of subchondral bone texture on magnetic resonance imaging with radiographic knee osteoarthritis progression: data from the Osteoarthritis Initiative Bone Ancillary Study

Test–Retest Reproducibility Analysis of Bone Mineral Densitometry Radiomics Features

Contact Info

Product

Resources

About