Subchronic co-exposure to particulate matter and fructose-rich-diet induces insulin resistance in male Sprague Dawley rats

PM2.5, component cause of severe metabolically abnormal obesity: An in silico, observational and analytical study

“…In this regard, several authors reported biological models that, following exposure to these particles, developed abnormal metabolism and/or alteration of biological pathways involved in metabolism [ [84] , [85] , [86] , [87] , [88] , [89] ]; moreover, Du et al [ 90 ] reported that the combined treatment of PM 2.5 and HFD had a synergistic effect on the onset and development of fatty liver disease. Furthermore, several other authors have reported murine models that, following direct and exclusive exposure to PM 2.5 , did not develop obesity [ [91] , [92] , [93] , [94] , [95] ]. However, regarding indirect or short-term exposures to PM 2.5 and their effect on the development of obesity, the evidence has been minimal and inconsistent, and the authors suggest further similar research to assess result reproducibility [ [96] , [97] , [98] , [99] ].…”