Subchronic Effects of Olanzapine on Sleep EEG in Schizophrenic Patients with Predominantly Negative Symptoms

Müller, Matthias J.; Rossbach, Wolfgang; Mann, Klaus; Röschke, Joachim; Müller-Siecheneder, F.; Blümler, M; Wetzel, Hermann; Russ, Hermann; Dittmann, R.W.; Benkert, Otto

doi:10.1055/s-2004-827170

Cited by 45 publications

(25 citation statements)

References 25 publications

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“…Similar effects on sleep-EEG sigma activity were also observed after administration of vilazodone in young healthy controls (Murck et al 2001;Viola et al 2002). In contrast to these results, atypical neuroleptics with pronounced dopaminergic effects lead to an elevation of delta-power in spectral analysis (Müller et al 2004).…”

Section: Discussionmentioning

confidence: 76%

Changes in sleep electroencephalogram and nocturnal hormone secretion after administration of the antidyskinetic agent sarizotan in healthy young male volunteers

et al. 2005

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Section: Discussionmentioning

confidence: 76%

Changes in sleep electroencephalogram and nocturnal hormone secretion after administration of the antidyskinetic agent sarizotan in healthy young male volunteers

et al. 2005

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“…These include gabatril (137), quietapine (138), olanzapine (139), and gabapentin (140). A number of these agents appear to increase the percentage of slow wave sleep observed on overnight polysomnnography (141,142).…”

Section: Other Agents Used As Hypnoticsmentioning

confidence: 97%

Current Patterns and Future Directions in the Treatment of Insomnia

Winkelman

Pies

2005

Annals of Clinical Psychiatry

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“…In particular, this difference is specially observed when analyzing sleep after drug administration [30] . In respect to olanzapine, the very few papers that have assessed the effects on sleep by means of traditional and spectral analysis showed increases in SWS without significant increments of the corresponding SWA [15,28,30,31] . Both approaches (visual scoring and spectral analysis) were considered in this paper by means of the evaluation of the SWS duration and the area under the curve of the SWA activity in each non-REM-REM sleep cycle, respectively.…”

Section: Discussionmentioning

confidence: 99%

Waking and Sleep Electroencephalogram Variables as Human Sleep Homeostatic Process Biomarkers after Drug Administration

et al. 2011

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Background/Aims: The correlation between theta activity during wakefulness and slow-wave activity (SWA) during sleep observed after sleep deprivation suggests such patterns can be used as electroencephalogram (EEG) biomarkers of the sleep homeostasis process. Since these EEG components would be very useful objective measures to assess CNS drug effects, we investigated whether the relationship between sleep homeostatic EEG biomarkers could be reproduced after an experimental pharmacological intervention. Methods: Seventeen healthy volunteers took part in a phase I randomized, double-blind, crossover design study. To increase sleep propensity, all participants received a single morning oral dose of olanzapine (5 mg) and placebo. Quantitative EEG analysis was done by power spectra calculations: theta activity (3.5–7.5 Hz) during wakefulness and SWA (0.5–4.0 Hz) during sleep. The relationship between the 2 EEG parameters was assessed by correlating the rise rate (percent/hour) of theta activity in wakefulness and the increase (percent) of SWA in the first non-REM sleep episode. Results: Following olanzapine administration we observed increases in theta activity during wakefulness, and increases in total sleep time, sleep efficiency and slow-wave sleep time during sleep. However, a weak and unreliable correlation was observed between the increases in theta activity and changes in sleep SWA. Conclusions: From these results, we cannot affirm that these waking and sleep EEG variables behave as biomarkers of human sleep homeostasis after drug administration. It is possible that these EEG biomarkers reflect different physiological mechanisms if they are assessed during drug CNS effects.

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Subchronic Effects of Olanzapine on Sleep EEG in Schizophrenic Patients with Predominantly Negative Symptoms

Abstract: Sleep improvement was due to parameters of sleep efficiency and delta sleep, which may be related to serotonin antagonistic properties of olanzapine.

Cited by 45 publications

References 25 publications

Changes in sleep electroencephalogram and nocturnal hormone secretion after administration of the antidyskinetic agent sarizotan in healthy young male volunteers

Changes in sleep electroencephalogram and nocturnal hormone secretion after administration of the antidyskinetic agent sarizotan in healthy young male volunteers

Current Patterns and Future Directions in the Treatment of Insomnia

Waking and Sleep Electroencephalogram Variables as Human Sleep Homeostatic Process Biomarkers after Drug Administration

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