Subchronic inhalation toxicity of ethylbenzene in mice, rats, and rabbits*1

Cragg, Steven T.; Clarke, Eric A.; Daly, Ira W.; Miller, R. R.; Terrill, James B.; Ouellette, R

doi:10.1016/0272-0590(89)90277-7

Cited by 22 publications

(1 citation statement)

References 6 publications

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“…Subakute und subchronische Studien an Ratten (Cragg et al 1989;European Chemical Industry Council 1999Shell Chemical Company 1983) lassen den Schluss zu, dass bei Ethylbenzolkonzentrationen unter 75 mL/m 3 toxische Wirkungen nicht mehr festgestellt werden können. Untersucht wurden dabei eventuelle Änderungen des Metabolismus, der Zellproliferation von Enzymaktivitäten und von Organgewichten.…”

Section: Subakute Und Subchronische Toxizitätunclassified

Ethylbenzol, Addendum [BAT Value Documentation in German language, 2007]

Angerer¹

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Biologische Arbeitsstoff‐Toleranz‐Werte (BAT‐Werte), Expositionsäquivalente für krebserzeugende Arbeitsstoffe (EKA) und Biologische Leitwerte (BLW) , 14. Lieferung, Ausgabe 2007 Der Artikel enthält folgende Kapitel: Ableitung der biologischen Expositionsäquivalente Metabolismus und Kinetik Kritische Toxizität Belastung und Beanspruchung Auswahl der Indikatoren Untersuchungsmethoden Hintergrundbelastung Evaluierung der biologischen Expositionsäquivalente Interpretation der Untersuchungsergebnisse

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Section: Subakute Und Subchronische Toxizitätunclassified

Ethylbenzol, Addendum [BAT Value Documentation in German language, 2007]

Angerer¹

2012

The MAK‐Collection for Occupational Health and Safety

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Aromatic Hydrocarbons—Benzene and Other Alkylbenzenes

Kerzic

2023

Patty's Toxicology

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Benzene and its alkyl derivatives are monocyclic aromatic compounds (arenes). The compounds are of considerable economic importance as industrial raw materials, solvents, and components of innumerable commercial and consumer products, and as precursors in the production of drugs, plastics, synthetic rubber, and dyes. The aromatics differ vastly in chemical, physical, and biological characteristics from the aliphatic and alicyclic hydrocarbons. The aromatics are typically more toxic to humans and other mammals than are the aliphatic and alicyclic hydrocarbons; toxic effects of prime importance are the toxicity of benzene to the hematopoietic system resulting in aplastic anemia, myelodysplastic syndromes (MDS), and acute myeloid leukemias (AML) as a result of chronic exposures, and central nervous system effects with acute exposures for the class. The simplest single‐ring aromatic hydrocarbon compound is benzene, the nonsubstituted ring system. When one methyl group is attached to the ring, methylbenzene or toluene is formed, and with two attached methyl groups, dimethylbenzene or xylene is formed. Xylene occurs in three isomeric forms: ortho (1,2)‐, meta (1,3)‐, and para (1,4)‐dimethylbenzene. Other important substituted benzenes are phenol (hydroxy‐) and aniline (amino‐). The hemimellitenes and mesitylenes possess three methyl groups, durene four, and the penta and hexamethylbenzenes, five and six methyl groups, respectively. Other industrially important compounds are ethylbenzene and isopropylbenzene or cumene.

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Aromatic Hydrocarbons—Benzene and Other Alkylbenzenes

Henderson¹

2001

Patty's Toxicology

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Benzene and its alkyl derivatives are monocyclic aromatic compounds (arenes). The compounds are of considerable economic importance as industrial raw materials, solvents, and components of innumerable commercial and consumer products. The aromatics differ vastly in chemical, physical, and biologic characteristics from the aliphatic and alicyclic hydrocarbons. The aromatics are more toxic to humans and other mammals; of prime importance are ( 1 ) the hematopoietic toxicity of benzene resulting in aplastic anemia in humans and other mammalian species, ( 2 ) benzene‐induced leukemia in humans, and ( 3 ) the cerebellar lesions and loss of central nervous system (CNS) integrative functions in “glue sniffers” exposed to high levels of toluene. The simplest single‐ring aromatic hydrocarbon compound is benzene, the nonsubstituted ring system. When one methyl group is attached to the ring, toluene is formed, and with two attached methyl groups, xylene is formed. Xylene occurs in three isomeric forms. The hemimellitines and mesitylenes possess three methyl groups, durene four, and the penta‐ and hexamethylbenzenes, five and six methyl groups, respectively. Other industrially important compounds are ethylbenzene and isopropylbenzene or cumene.

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Subchronic inhalation toxicity of ethylbenzene in mice, rats, and rabbits*1

Cited by 22 publications

References 6 publications

Ethylbenzol, Addendum [BAT Value Documentation in German language, 2007]

Ethylbenzol, Addendum [BAT Value Documentation in German language, 2007]

Aromatic Hydrocarbons—Benzene and Other Alkylbenzenes

Aromatic Hydrocarbons—Benzene and Other Alkylbenzenes

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