Subchronic oral toxicity of turmeric oleoresin in pigs

Bille, N.; Larsen, John Christian; Hansen, E.; Würtzen, G.

doi:10.1016/0278-6915(85)90245-5

Cited by 33 publications

(15 citation statements)

References 11 publications

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“…In the present study also, the normal liver histology was unaffected after the two doses of curcumin feeding, confirming an in vivo protective effect. The results were also consistent with observations by some authors in rats, guinea pigs, monkeys, and pigs (Wahlstrom and Blennow 1978;Fish Physiol Biochem (2012) 38:309-318 313 Bhavanishankar et al 1980;Bille et al 1985). However, there are studies which revealed that administration of turmeric extract induced hepatotoxic effects in mice and rats Kandarkar et al 1998).…”

Section: Discussionsupporting

confidence: 93%

In vivo protective effect of dietary curcumin in fish Anabas testudineus (Bloch)

Manju

Akbarsha²,

Oommen

2011

Fish Physiol Biochem

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The present study describes, for the first time, the protective effect of natural curcumin in vivo in a lower vertebrate, a teleost, Anabas testudineus (Bloch). Two doses of curcumin 0.5 and 1% were supplemented in the 40% protein feed and fed to fish for the periods, 2 and 8 weeks. The antioxidant status, protein content, and the tissue structure in experimental fish were examined after the short-term and long-term feeding. In all the curcumin fed groups, the lipid peroxidation product, thiobarbituric acid reactive substances content either decreased or unaffected. The glutathione content increased while the antioxidant enzyme activity pattern varied with time and dose. The histological analysis also confirmed the safety of curcumin retaining the normal arrangement of hepatocytes, hepatopancreas, macrophage-melanocyte centers in Anabas. The improved antioxidant status and protein content suggest a favorable effect for curcumin in cultured fish.

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Section: Discussionsupporting

confidence: 93%

In vivo protective effect of dietary curcumin in fish Anabas testudineus (Bloch)

Manju

Akbarsha²,

Oommen

2011

Fish Physiol Biochem

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“…The minimal effective dosage (30 M) is within the functional range of curcumin (10 -100 M) published previously (33), and more important, within this range, we and others did not find significant toxic effects (8). Curcumin with 50 mg/kg body weight has been applied to rats via intravenous injection (34).…”

Section: Discussionmentioning

confidence: 82%

“…Commonly used as a yellow coloring and flavoring agent in food, curcumin has shown no toxic effects. Toxicity studies with curcumin in animals indicated no significant histopathologic changes (8), and prolonged administration for three generations did not show any teratogenic or carcinogenic effects (9). Curcumin possesses anticarcinogenic properties (10).…”

mentioning

confidence: 97%

Proapoptotic effect of curcumin on human neutrophils: Activation of the p38 mitogen-activated protein kinase pathway*

Vancurova

et al. 2005

Critical Care Medicine

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“…[25][26][27] In order to use this compound for leishmaniasis or to use as a lead compound, we need to clarify the mechanism of its cytotoxicity. 132 Vol.…”

Section: Fig 1 Leishmanicidal Effect Of Curcumin On Promastigotes Omentioning

confidence: 99%

Leishmanicidal Effect of Curcumin in Vitro.

Koide

Nose

Ogihara

et al. 2002

Biological & Pharmaceutical Bulletin

111

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The ground dried rhizome of the plant, Curcuma longa LINN has long been used as a naturally occurring medicine for the treatment of inflammatory and other diseases, and has also been used as a coloring agent and spice in many foods. 1)The powdered rhizome is commonly called turmeric. Curcumin (diferuloylmethane) is a major active ingredient that has been identified as the major pigment in turmeric. Curcumin is well known as a potent anti-oxidant, 2,3) and recent studies have revealed that it is a potent inhibitor of reactive oxygen-generating enzymes, such as lipoxygenase/cyclooxygenase, 4,5) xanthine dehydrogenase/oxidase 6) and inducible nitric oxide synthase 7) and it possesses anti-inflammatory activity. 8,9) Moreover, it has shown anti-carcinogenic activity in animal models, such as colon tumor initiation by azoxymethane 10) and skin tumor promotion induced by phorbol ester TPA.11) Recently, curcumin has been considered by oncologists as a potential third generation cancer chemopreventive agent, and clinical trials using it have been carried out in several laboratories.Leishmania such as Leishmania major are the protozoan parasite responsible for leishmaniasis. So far, medicines used for the treatment of leishmaniasis such as pentavalent antimonials and pentamidine are toxic or have severe side effects, for example renal, cardiac and neural toxicity, shock and risk of diabetes.12) Other medicines such as amphotericin B are restricted to hospital use. In addition, resistance towards these medicines have been observed. 13) Thus, the development of a new agent is urgently needed.During the search for the candidate of anti-parasitic agents from natural resources, we have found that curcumin has leishmanicidal activity in vitro. MATERIALS AND METHODSChemicals Curcumin was purchased from Funakoshi Co., Ltd. (Tokyo, Japan) and other chemicals used were special grade.Axenic Cultivation of Leishmania The medium used for the cultivation of promastigotes of L. major (MHOM/ SU/73/5ASKH) was SDM-79, previously described by Brun and Schonenberger.14) Leishmania were cultured into 25 cm 2 -tissue culture flasks containing 5 ml of culture medium per flask and maintained therein at 27°C in an atmosphere of 5% CO 2 -95% air.Leishmanicidal Assay Cultured leishmania of promastigotes were centrifuged at 600 g for 5 min at 4°C, and the parasites then resuspended with culture medium, diluted to a density of 5ϫ10 5 /ml and inoculated into 96-well plate. The medium (0.1 ml) containing various concentrations of curcumin dissolved in dimethyl sulfoxide (DMSO) was added into each well and incubated at 27°C in an atmosphere of 5% CO 2 -95% air. The final concentration of DMSO was 0.5%. After incubation for an appropriate period, the number of surviving leishmania was determined microscopically by counting in a Burker-Turk hemocytometer. The leishmanicidal activity of curcumin was shown as 50% growth inhibitory concentration (GI 50 ), 100% growth inhibitory concentration (TGI) and LD 50 after incubation with leishmania for 24 h. 100% gr...

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Subchronic oral toxicity of turmeric oleoresin in pigs

Cited by 33 publications

References 11 publications

In vivo protective effect of dietary curcumin in fish Anabas testudineus (Bloch)

In vivo protective effect of dietary curcumin in fish Anabas testudineus (Bloch)

Proapoptotic effect of curcumin on human neutrophils: Activation of the p38 mitogen-activated protein kinase pathway*

Leishmanicidal Effect of Curcumin in Vitro.

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