Subchronic Toxicity of Acrylamide in Fried Rice and Preventive Effect of Grape Leaves

Protective effects of Syzygium aromaticum oil (Clove) against acrylamide induced hepatic, renal, and testicular toxicity in rats

“…The effect of acrylamide administration on AST and ALT levels were in accordance with(Sawk et al 2007;Sharma and Jain 2008;Gabr et al 2010;Teodor et al 2011). The present results for the effect of acrylamide upon the serum liver enzymes activity also agreed with Siahkoohi1 et al (2014) andOsman et al (2016) who reported a significant increase in serum AST and ALT levels in acrylamide -treated adult male rats compared with control. The elevation in serum AST and ALT activities may be resulted from the increase permeability of hepatocyte cell membrane which may occur due to the toxic effect of acrylamide which cause cellular damage and in turn leakage of the enzymes outside the cellular structure to extracellular fluid.…”

Counter effect of bee venom and its extracted bradykinin-potentiating factor on acrylamide and chips administration-induced complications in the liver and kidney of male mice

“…The current study showed that the administration of acrylamide of a chemical or from an overheated carbohydrate-rich food provoked a significant increase in the plasma enzyme marker of hepatocellular injury (AST/GOT) and (ALT/GPT) that coincides with previous studies (Osman et al, 2016;Rawi, Marie, Fahmy, & El-Abied, 2012). Acrylamide increases the degree of membrane permeability of the liver and induces cellular transformation (Awad, Abdel-Rahman, & Hassan, 1998).…”

“…Vacuolation of hepatocytes as ballooning degeneration is considered as the cellular defensive mechanism against injurious elements (Abdel Hameed, 2004), and these vacuoles are responsible for collecting the injurious substances and preventing them from interfering with the biological activities of these cells (Cheville, 2009). Similar results have demonstrated that the severity of the lesions that causes hepatotoxicity by acrylamide increases with the doses of acrylamide (AL-Mosaibih, 2013;Osman, Romeilah, Elgammal, Ramis, & Hasan, 2016). Moreover, disruption of the pattern of hepatic cords, the incidence of necrosis, congestion of blood vessels, lymphocyte infiltration, inflammation, and vacuolization of hepatocytes were reported in rats exposed to acrylamide (Osman et al, 2016;Siahkoohi, Anvari, Tafti, & Sharifabad, 2014).…”

“…Similar results have demonstrated that the severity of the lesions that causes hepatotoxicity by acrylamide increases with the doses of acrylamide (AL-Mosaibih, 2013;Osman, Romeilah, Elgammal, Ramis, & Hasan, 2016). Moreover, disruption of the pattern of hepatic cords, the incidence of necrosis, congestion of blood vessels, lymphocyte infiltration, inflammation, and vacuolization of hepatocytes were reported in rats exposed to acrylamide (Osman et al, 2016;Siahkoohi, Anvari, Tafti, & Sharifabad, 2014). The cytoplasmic vacuolization of the hepatic cells was attributed to the progressive ischemia, lipid accumulation, and hypoxia in the cells (Abdul-Hamid & Moustafa, 2005;Moustafa & Abdul-Hamid, 2007).…”

Biological Activities of Black Truffle (TerfeziaClaveryi) Against Dietary Acrylamide-Induced Toxicity in Rats Liver: Biochemical and Histopathological Study

“…The toxicity of BT extracts was evaluated in ten healthy rats administrated the extract (Organization for Economic Cooperation and Development (OECD, 2001) (Osman et al, 2016). In drinking water, the rats received orally a gradual concentration of the BT extracts (50 mg to 1000 mg/rat).…”