2005
DOI: 10.1016/j.jep.2004.11.021
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Subchronic toxicity studies of the antidiabetic herbal preparation ADD-199 in the rat: absence of organ toxicity and modulation of cytochrome P450

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Cited by 23 publications
(11 citation statements)
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“…Treatment of wounds [35], skin diseases, eczema, psoriasis and leprosy [36], rheumatism, snakebites, and syphilis [216] Antibacterial, antifungal, anti-inflammatory, analgesic, antidiabetic, and antioxidant activities [217] Markhamia lutea (Benth.) K. Schum.…”
Section: Lovoa Trichilioides Harmsmentioning
confidence: 99%
“…Treatment of wounds [35], skin diseases, eczema, psoriasis and leprosy [36], rheumatism, snakebites, and syphilis [216] Antibacterial, antifungal, anti-inflammatory, analgesic, antidiabetic, and antioxidant activities [217] Markhamia lutea (Benth.) K. Schum.…”
Section: Lovoa Trichilioides Harmsmentioning
confidence: 99%
“…Cytotoxic effect at high concentrations of hexane extract (CC50 = 9.37 μg/mL) on LLC/MK2 monkey kidney cells (Zofou et al, 2011); no specific toxicity in rats of the mixture of the plant (Martey et al, 2010;Nyarko et al, 2005) Hepatoprotective activity on acetaminophen-induced liver damage in mice (Olaleye and Rocha, 2008).…”
Section: Plant Parts Used Modes Of Preparation and Administration Romentioning
confidence: 99%
“…Biochemical estimations in the blood and hematological evaluations are important indicators in finding out the mechanism of toxic effect [47][48][49] and the parameters have been selected not only to detect target organ toxicity but also to detect pretoxic changes that might predict impending toxicity. 38,43 The results are shown in Table 2 male and female wistar rats.…”
Section: Discussionmentioning
confidence: 99%