Subclinical activation of coagulation and fibrinolysis in laparoscopic cholecystectomy: Do risk factors exist?

Ntourakis, Dimitrios; Sergentanis, Theodoros N.; Georgiopoulos, Ioannis; Papadopoulou, Eleni; Liasis, L.; Kritikos, E.; Tzardis, P.; Laopodis, V.

doi:10.1016/j.ijsu.2011.02.011

Cited by 18 publications

(23 citation statements)

References 23 publications

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“…38 More sizeable changes in coagulation activation were observed in the elderly patients. 33 Perioperative changes in blood coagulation during laparoscopic cholecystectomy were smaller than during open cholecystectomy, 34,35 and changes were no greater than observed following low-risk surgery. 36 Strengths of these data are the huge number of patients with data obtained over 11 years from all regions of United State, all ethnicities, both genders, and all age groups.…”

Section: Discussionmentioning

confidence: 86%

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Pulmonary Embolism and Deep Venous Thrombosis Following Laparoscopic Cholecystectomy

Stein

Matta

Sabra

2013

Clin Appl Thromb Hemost

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There is considerable uncertainty related to the thromboembolic risk after laparoscopic cholecystectomy. Patients with pulmonary embolism (PE), deep venous thrombosis (DVT), or venous thromboembolism (VTE) at hospital discharge following laparoscopic cholecystectomy were identified from the Nationwide Inpatient Sample. From 1998 through 2009, 4 107 430 laparoscopic cholecystectomies were performed. The in-hospital prevalence of PE was 0.15%, DVT was 0.40%, and VTE was 0.53%. The prevalence of PE increased from 0.04% in patients aged 21 to 30 years to 0.31% in patients aged 71 to 80 years. Deaths due to in-hospital PE were 780 (0.02%) of the 4 107 430 laparoscopic cholecystectomies. The rate of death increased with age. The prevalence of VTE following laparoscopic cholecystectomy is low and fatal PE is rare. The risk of VTE increased with age, as did the risk of death in those who had PE. These data may be useful in assessing the use of thromboprophylaxis in patients undergoing laparoscopic cholecystectomy.

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Section: Discussionmentioning

confidence: 86%

“…27 Several investigations showed markers of postoperative hypercoagulability. [30][31][32][33][34][35][36][37] One investigation showed no hemostatic changes in blood draining the lower limbs. 38 More sizeable changes in coagulation activation were observed in the elderly patients.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Embolism and Deep Venous Thrombosis Following Laparoscopic Cholecystectomy

Stein

Matta

Sabra

2013

Clin Appl Thromb Hemost

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“…Ntourakis et al showed in a observational study of 119 Blow risk^VTE patients undergoing elective laparoscopic cholecystectomy that elderly patients (>70 years) not only had a higher concentration of D-dimer preoperatively, but also expressed significantly higher postoperative Ddimer levels on the first day after surgery compared to younger patients [30]. Hence, a raised coagulation response in elderly patients and an observed increased risk for developing postoperative PE after cholecystectomy warrants a more liberate use of TP in this patient group.…”

Section: Discussionmentioning

confidence: 99%

Incidence and risk factors for symptomatic venous thromboembolism following cholecystectomy

Strömberg

Sadr–Azodi

Videhult

et al. 2015

Langenbecks Arch Surg

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“…The comparison of the length of PT and APTT before and after the surgery did not demonstrate any statistically significant differences [27][28][29].…”

Section: Von Willebrand Factormentioning

confidence: 74%

Evaluation of selected parameters of the coagulation system during the perioperative period in patients undergoing endoscopic surgery of the paranasal sinuses

Urbaniak¹,

Owczarek²,

Miłoński³

et al. 2020

aoms

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A b s t r a c tIntroduction: The aim of the study was to evaluate selected parameters of the coagulation system during the perioperative period in patients undergoing endoscopic sinus surgery. Material and methods: The study involved 121 patients: group I -42 patients who did not receive anticoagulatory or antiplatelet medications, qualified for endoscopic sinus surgery under total intravenous anaesthesia (TIVA); group II -40 patients who received in the perioperative period low-molecular-weight heparins, qualified for endoscopic sinus surgery under TIVA; group III -39 patients diagnosed according to a schedule, due to vertigo or loss of hearing. All the patients received a full laryngological examination and detailed audiological and otoneurological diagnostics, and examination of selected haemostatic parameters before the surgery/diagnostics. Results: The analysis of concentrations of coagulation parameters in groups I and II revealed a statistically significantly higher international normalized ratio value before surgery (I -1.11; II -1.08) and 48 h following surgery (I -1.15; II -1.10) in group I. The concentration of coagulation factor VII in the study patients was considerably higher in group I for all three measurements (481.93; 443.13; 486.02). The concentration of fibrinogen (coagulation factor I) was significantly lower in group I before surgery (3.2) and at 6 h after surgery (2.84). A significantly lower level of von Willebrand factor was found in group I before surgery (2.94). Comparing test results of groups I and III, who did not receive antiaggregants, statistically significant differences were observed in both tests for factors VII and VIII. Conclusions: Concentrations of von Willebrand factor and prothrombin revealed statistically significant differences in between groups.

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Subclinical activation of coagulation and fibrinolysis in laparoscopic cholecystectomy: Do risk factors exist?

Abstract: Despite no DVT, significant increase in PT-INR, d-dimer, FDP and fibrinogen appeared after LC. This may be attributed to surgical trauma and pneumoperitoneum effects on the portal vein flow. Elderly subjects and males seem particularly vulnerable, demonstrating more sizeable changes.

Cited by 18 publications

References 23 publications

Pulmonary Embolism and Deep Venous Thrombosis Following Laparoscopic Cholecystectomy

Pulmonary Embolism and Deep Venous Thrombosis Following Laparoscopic Cholecystectomy

Incidence and risk factors for symptomatic venous thromboembolism following cholecystectomy

Evaluation of selected parameters of the coagulation system during the perioperative period in patients undergoing endoscopic surgery of the paranasal sinuses

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