Subclinical atherosclerosis in Behcet’s disease: A systematic review and meta-analysis

Merashli, Mira; Ster, Irina Chis; Ames, P. R. J.

doi:10.1016/j.semarthrit.2015.06.018

Cited by 42 publications

(32 citation statements)

References 48 publications

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“…In our study, early and accelerated atherosclerosis was not observed in BD patients, which is in contrast to previous studies (32). A previous study showed increased cIMT values in BD patients with vascular involvement compared to those without vascular involvement (27).…”

Section: Discussioncontrasting

confidence: 99%

Carotid artery stiffness in Behçet’s disease

Yolbaş¹,

Gözel²,

Dağlı³

et al. 2017

Eur J Rheumatol

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Section: Discussioncontrasting

confidence: 99%

Carotid artery stiffness in Behçet’s disease

Yolbaş¹,

Gözel²,

Dağlı³

et al. 2017

Eur J Rheumatol

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“…This may be one of the main reasons for the disparities in the results of previous studies. A meta‐analysis by Merashli et al also emphasized a large heterogeneity among 15 studies reviewed for CIMT analysis …”

Section: Discussionmentioning

confidence: 99%

Evaluation of subclinical atherosclerosis by ultrasound radiofrequency data technology in patients with Behçet's disease

Kaplanoğlu

2019

Int J of Rheum Dis

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Aim We aimed to evaluate subclinical atherosclerosis based on carotid intima‐media thickness (CIMT) and arterial stiffness measurements in patients with Behçet's disease (BD), using ultrasound (US) radiofrequency (RF) data technology. Methods We included 33 BD patients and 33 healthy controls in this study. The participants did not have any primary cardiovascular risk factors, such as diabetes mellitus, hypertension, hyperlipidemia and obesity. All participants were evaluated using Doppler ultrasonography. Arterial stiffness and CIMT measurements were performed in bilateral common carotid arteries using the US RF data technology. Results The right, left and mean CIMT values were similar between the patient and control groups (P > 0.05). There was also no statistically significant difference in the right side α and β stiffness indices despite higher values in the patient group (P > 0.05). The right, left and mean distensibility coefficient (DC) and compliance coefficient (CC) values of the patient group were significantly lower than the control group (P < 0.05). The left and mean α‐ and β‐stiffness indices, and the right, left and mean pulse wave velocity (PWV) values were significantly higher in the patient group (P < 0.05). We found higher mean CIMT and PWV values, and α‐ and β‐stiffness indices in patients with mucocutaneous involvement compared with those with major organ involvement, while the mean DC and CC values were lower in the former. However, these results did not reach a statistically significant level. Conclusion This study demonstrated evidence of subclinical atherosclerosis in BD in the absence of major atherosclerotic risk factors.

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“…They proposed that spontaneous coronary artery dissection could possibly be a cause of coronary ischemia in BD [110]. A recent meta-analysis pointed to the fact that subclinical atherosclerosis, not clinically apparent atherosclerosis, is increased in BD as depicted by impaired flow-mediated dilatation and increased intima-media thickness but whether this translates into coronary artery disease in time is controversial [111].…”

Section: Spontaneous Coronary Artery Dissectionmentioning

confidence: 99%

“…It is important to know that thrombus disappears after the initiation of immunosuppressive therapy [129]. Medical treatment with immunosuppressants may be the first choice for patients with BD who have ICT [111]. To avoid a progression to thrombus or cardiac dysfunction in recurrent cases, the early identification of cardiac involvement of BD using echocardiography and/or cardiac magnetic resonance imaging is of great importance.…”

Section: Medical Treatmentmentioning

confidence: 99%

“…To avoid a progression to thrombus or cardiac dysfunction in recurrent cases, the early identification of cardiac involvement of BD using echocardiography and/or cardiac magnetic resonance imaging is of great importance. Combined immunosuppressive therapy with prednisolone and cyclophosphamide are usually needed to treat recurrent thrombosis due to BD [111,129].…”

Section: Medical Treatmentmentioning

confidence: 99%

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Vascular Manifestations of Behçet’s Disease

Demïrtürk¹,

Tünel²,

Alemdaroğlu³

2017

Behcet's Disease

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Behçet's disease (BD), a very morphologically diverse systemic disease, may involve the vascular system. The venous system is the most frequently attacked vessel system.The arterial system, when involved, increases the severity and morbidity of Behçet's disease. Cardiac involvement, although rare, can be very subtle and in itself increases the mortality. Vasculitis is the hallmark pathology resulting in occlusion, aneurysms, or both.Vascular involvement may be very challenging in all phases of treatment beginning from diagnosis till recovery and remission.

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Subclinical atherosclerosis in Behcet’s disease: A systematic review and meta-analysis

Abstract: FMD is impaired in BD even in inactive state and IMT is greater despite a degree of statistical heterogeneity that reflects the clinical heterogeneity of BD. Future prospective studies should account for risk stratification of atherosclerosis in BD.

Cited by 42 publications

References 48 publications

Carotid artery stiffness in Behçet’s disease

Carotid artery stiffness in Behçet’s disease

Evaluation of subclinical atherosclerosis by ultrasound radiofrequency data technology in patients with Behçet's disease

Vascular Manifestations of Behçet’s Disease

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