Subclinical atherosclerosis in subjects with family history of premature coronary artery disease

Taraboanta, Catalin; Wu, Evelyn; Lear, Scott A.; DiPalma, S.; Hill, John S.; Mancini, G.B. John; Fröhlich, Jiří

doi:10.1016/j.ahj.2007.11.046

Cited by 12 publications

(12 citation statements)

References 30 publications

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“…The main reason for this is the lack of specific guidelines as to which screening test to use for the initial screening. Taraboanta et al [26] found FDRs of premature CAD to have a higher burden of subclinical coronary atherosclerosis and plasma homocystein, which was correlated with a family history of CAD independent of the conventional coronary risk factors. Although we did not determine the homocystein level in this study, other inflammatory markers such as FDRs Control (a) Prevalence of CAD and at least 50% CAD.…”

Section: Associating Factors Of Subclinical Coronary Artery Disease Omentioning

confidence: 98%

Prevalence and determinants of coronary artery disease in first-degree relatives of premature coronary artery disease

Kang

Chang²,

Kim

et al. 2012

Coronary Artery Disease

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Section: Associating Factors Of Subclinical Coronary Artery Disease Omentioning

confidence: 98%

Prevalence and determinants of coronary artery disease in first-degree relatives of premature coronary artery disease

Kang

Chang²,

Kim

et al. 2012

Coronary Artery Disease

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“…23 Whether this association may be mediated by more advanced angiographic burden of CAD, as opposed to a higher propensity for thrombosis or other mechanism, has not been established. 11,[24][25][26][27] Accordingly, we evaluated whether a FHx of premature myocardial infarction (MI) and a GRS comprised of 30 single-nucleotide polymorphisms (SNPs) identified in genome-wide association studies were independently associated with the burden of CAD at the time of angiography in young patients (aged ≤55 years) with ACS and whether the presence of both of these risk factors further increased the extent and severity of angiographic CAD.…”

mentioning

confidence: 99%

Association Between Family History, a Genetic Risk Score, and Severity of Coronary Artery Disease in Patients With Premature Acute Coronary Syndromes

Hindieh

Pilote

Cheema

et al. 2016

ATVB

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Objective-A genetic risk score (GRS) for coronary artery disease has recently been shown to be independent of family history (FHx) in predicting future cardiovascular events. We sought to determine whether the presence of these risk factors, either individually or together, was associated with a higher burden of angiographic coronary artery disease. Approach and Results-We included 763 patients with premature acute coronary syndrome (median age, 50 [46-53] years; 30.8% women) with at least 1 major epicardial vessel stenosis enrolled in the Gender and Sex Determinants of Cardiovascular Disease From Bench to Beyond in Premature Acute Coronary Syndrome (GENESIS-PRAXY) study, a multicentre prospective cohort study of premature patients with acute coronary syndrome (aged ≤55 years). Key Words: acute coronary syndrome ◼ atherosclerosis ◼ cohort studies ◼ coronary heart disease ◼ genetics ◼ myocardial infarction

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“…4 However, although a family history of premature CHD in first-degree relatives is associated with increased risk of CHD, [1][2][3][4][5] increased burden of risk factors, subclinical atherosclerosis, 6 and metabolic syndrome, 7,8 there have been very few prospective, population-based studies of family history of vascular disease in patients with MI, and prevalence of positive family history ranges from 5.3% to 34.3%, depending on the definition used 9 -12 (Table 1).…”

mentioning

confidence: 99%

Sex-Specific Familial Clustering of Myocardial Infarction in Patients With Acute Coronary Syndromes

Banerjee

Silver

Heneghan

et al. 2009

Circ Cardiovasc Genet

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Background-Family history of premature myocardial infarction (MI) in first-degree relatives is a risk factor for MI and an indication for primary prevention. Although excess mother-to-daughter "transmission" occurs in ischemic stroke, no published studies have considered sex-of-parent/sex-of-proband interactions in the heritability of MI. Methods and Results-In a population-based study (Oxford Vascular Study) of all patients with acute coronary syndromes (ACS), irrespective of age, family history of all acute vascular events and related risk factors were analyzed by sex and age of both probands and first-degree relatives. Premature events were categorized as occurring at age Ͻ65 years. Of 835 probands with 1 or more ACS, 623 (420 men) had incident events and complete family history data. In probands with premature ACS, maternal history of both MI and of all vascular events were more common in female than male probands (odds ratio Greater emphasis should be placed on maternal than paternal history of MI, particularly in women aged Ͻ65 years.

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Subclinical atherosclerosis in subjects with family history of premature coronary artery disease

Cited by 12 publications

References 30 publications

Prevalence and determinants of coronary artery disease in first-degree relatives of premature coronary artery disease

Prevalence and determinants of coronary artery disease in first-degree relatives of premature coronary artery disease

Association Between Family History, a Genetic Risk Score, and Severity of Coronary Artery Disease in Patients With Premature Acute Coronary Syndromes

Sex-Specific Familial Clustering of Myocardial Infarction in Patients With Acute Coronary Syndromes

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