Subclinical atherosclerosis in the carotid artery: can the ankle-brachial index predict it in type 2 diabetes patients?

Kärberg, Kati; Lember, Margus

doi:10.1080/00365513.2021.1904279

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…Venous blood samples were collected for analysis of serum concentrations of HbA1c, total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and highsensitivity C reactive protein (hsCRP). Hypertension was defined as systolic blood pressure above 140/90 mmHg and hyperlipidemia as LDL-C level !2.6 mmol/L (100 mg/dL) (as a diabetic patient without target organ damage has moderate cardiovascular risk) [39,40]. Visceral adiposity indices (VAI) were calculated by the following formulas:…”

Section: Clinical and Biochemical Measurementsmentioning

confidence: 99%

“…One sonographer performed all carotid intima-media thickness (IMT) measurements using a high-resolution B-mode tomographic ultrasound system (Philips Affiniti 70 G, Philips Healthcare, 3000 Minuteman Road, Andover, MA) with a linear 12 MHz transducer. The exact procedure is described in a previously published article [39]. Measurements were made manually from the far wall in the common carotid artery (CCA) 10 mm proximal to the bifurcation, in the bulb and distal internal carotid artery (ICA) 5e10 mm from the bulb in an area free of plaque.…”

Section: Measurement Of Carotid Artery Imtmentioning

confidence: 99%

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Raised dietary Zn:Cu ratio increases the risk of atherosclerosis in type 2 diabetes

Kärberg

Forbes

Lember

2022

Clinical Nutrition ESPEN

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Section: Clinical and Biochemical Measurementsmentioning

confidence: 99%

Section: Measurement Of Carotid Artery Imtmentioning

confidence: 99%

Raised dietary Zn:Cu ratio increases the risk of atherosclerosis in type 2 diabetes

Kärberg

Forbes

Lember

2022

Clinical Nutrition ESPEN

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“…Carotid intima–media thickness (IMT) was used to characterise subclinical atherosclerosis in the carotid artery. A single sonographer performed the measurements using a high-resolution B-mode tomographic ultrasound system (Philips Affiniti 70 G, Philips Healthcare, 3000 Minuteman Road, Andover, MA, USA) with a linear 12 MHz transducer, as described previously [ 26 ]. For an overview of the vessel orientation, plaque and surrounding structures, a transverse scan was taken of the proximal part of the common carotid artery (CCA) throughout the bulb to the distal internal carotid artery (ICA) and the external carotid artery.…”

Section: Methodsmentioning

confidence: 99%

Visfatin and Subclinical Atherosclerosis in Type 2 Diabetes: Impact of Cardiovascular Drugs

2023

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Background and Objectives: The role of adipokines in the development of atherosclerosis in type 2 diabetes (T2DM) has not yet been fully elucidated. The effects of drugs on adipokine concentrations have only been evaluated in very few studies, although they may be of clinical importance. This study aimed to assess whether the concentrations of circulating adipokines could predict subclinical atherosclerosis in patients with T2DM, as well as their interactions with commonly used cardiovascular drugs. Materials and Methods: Our population-based cross-sectional multicentric study included 216 participants with T2DM but without previously diagnosed atherosclerosis. The carotid artery intima–media thickness (IMT), plaque and ankle–brachial index (ABI) metrics were measured. Resistin, visfatin, retinol-binding protein 4, high molecular weight adiponectin and leptin levels were evaluated using Luminex’s xMAP technology. Results: Visfatin and resistin concentrations correlated positively with IMT (p = 0.002 and p = 0.009, respectively). The correlation of visfatin to IMT ≥ 1.0 mm was significant in males (p < 0.001). Visfatin had a positive correlation with IMT ≥ 1.0 mm or plaque (p = 0.008) but resistin only correlated with plaque (p = 0.049). Visfatin predicted IMT ≥ 1.0 mm or plaque in patients on β-blocker monotherapy (p = 0.031). Visfatin lost its ability to predict subclinical atherosclerosis in patients taking angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers or statins. After adjustments for risk factors for atherosclerosis and cardiovascular drugs, visfatin maintained an independent association with mean IMT (p = 0.003), IMT ≥ 1.0 mm or plaque (p = 0.005) and ABI ≤ 0.9 (p = 0.029). Conclusions: Visfatin could be used as a marker of subclinical atherosclerosis in patients with T2DM, especially in males. The assessment of visfatin concentration could aid in identifying individuals who could benefit from implementing preventive measures against atherosclerosis.

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“…Oxidative stress is also involved in the formation and development of arterial plaques and oxidative modification of Low-Density Lipoprotein (LDL) and oxidative stress in vascular endothelial cells can contribute to the formation of vulnerable plaques. Other factors such as the nature of the plaque and the external forces on the plaque can contribute to the development, progression and even rupture of the plaque [6] .…”

mentioning

confidence: 99%

Correlation Study of Serum Dickkopf 4 Level with Metabolic Syndrome and Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus

Zhao¹,

Hou²

2023

IJPS

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Study of Serum Dickkopf 4 with Metabolic Syndrome and Carotid Atherosclerosis in Type 2 Diabetes MellitusTo investigate the characteristics of Dickkopf 4 changes in patients with type 2 diabetes mellitus and its correlation with carotid atherosclerosis, is the objective of the study. A cross-sectional survey was performed and eligible patients with type 2 diabetes mellitus were taken as the subjects. Lifestyle, physical measurements, blood biochemical parameters and relevant imaging examinations were collected from all participating subjects. 237 type 2 diabetes mellitus patients were included in present study and divided into four groups according to the quartiles of serum Dickkopf 4. The incidence of body mass index, fasting plasma glucose, fasting C-peptide, glycated haemoglobin, insulin resistance index, total cholesterol, triglycerides, low-density lipoprotein, C-reactive protein, high-density lipoprotein, and non-alcoholic fatty liver disease, carotid atherosclerosis were compared between groups, p<0.05. Dickkopf 4 was positively correlated with body mass index, C-reactive protein, fasting plasma glucose, fasting C-peptide, glycated haemoglobin, total cholesterol, triglycerides, low-density lipoprotein, insulin resistance index and creatinine, and negatively correlated with high-density lipoprotein and estimated glomerular filtration rate, p<0.05. Non-metabolic syndrome group and metabolic syndrome group were compared and non-carotid atherosclerosis group and carotid atherosclerosis group were compared for all the parameters (p<0.05). High Dickkopf 4 was an independent risk factor for metabolic syndrome (odds ratio=2.023, 95 % confidence interval: 1.042-3.926, p=0.037). Binary logistic regression analysis, high Dickkopf 4 was an independent risk factor for carotid atherosclerosis (odds ratio=2.513, 95 % confidence interval: 1.379-2.513, p=0.003). High Dickkopf 4 is a risk factor for hypertension and non-alcoholic fatty liver disease in type 2 diabetic patients and an independent risk factor for metabolic syndrome and carotid atherosclerosis in type 2 diabetic mellitus patients.

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Subclinical atherosclerosis in the carotid artery: can the ankle-brachial index predict it in type 2 diabetes patients?

Cited by 3 publications

References 32 publications

Raised dietary Zn:Cu ratio increases the risk of atherosclerosis in type 2 diabetes

Raised dietary Zn:Cu ratio increases the risk of atherosclerosis in type 2 diabetes

Visfatin and Subclinical Atherosclerosis in Type 2 Diabetes: Impact of Cardiovascular Drugs

Correlation Study of Serum Dickkopf 4 Level with Metabolic Syndrome and Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus

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