Subclinical cardiac disease in ankylosing spondylitis

Özen, Selin; Özen, Anıl; Ünal, Ertekin Utku; Tüfekçioğlu, Omaç; Ataman, Şebnem; Yalcin, A.

doi:10.1111/echo.14103

Cited by 10 publications

(7 citation statements)

References 28 publications

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“… 12 Selin Ozen and colleagues also demonstrated that increased left ventricular global longitudinal strain is seen in AS patients. 13 Apart from subclinical myocardial dysfunction many studies have also showed subclinical atherosclerosis in AS patients. 11 – 15 …”

Section: Discussionmentioning

confidence: 99%

Speckle Tracking Echocardiography in Patients with Ankylosing Spondylitis and Evaluation of Subclinical Involvement

Aghdashi,

Mikaeilvand,

Ansari-Ramandi

et al. 2023

MJR

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Introduction: Ankylosing spondylitis (AS) is a chronic inflammatory condition primarily affecting the spine and the joints. It also affects multiple organs in the body including the cardiovascular system. Left ventricular (LV) global longitudinal strain (GLS) is a good measure for recognizing subclinical myocardial dysfunction. This study aimed to investigate if there is sub-clinical LV myocardial systolic dysfunction present in AS patients independent of the presence of cardiovascular disease risk factors. We also aimed to see if the GLS is associated with the aortic root abnormality present in these patients. Methods: Twenty-eight AS patients (mean age 40.6±10.9 years) were investigated in this cross-sectional case-control study. The control group (mean age 45.2±5 years) comprised 26 healthy individuals. Conventional and speckle tracking echocardiography was performed for all patients. LV systolic myocardial function was assessed by systolic GLS. Aortic diameters and diastolic function were also evaluated. Results: The baseline characteristics and cardiovascular risk factors of the case and control groups were similar and did not differ significantly. The AS patients were suffering more from diastolic dysfunction in comparison to the control group (p=0.009). We only found a significantly impaired longitudinal strain in the 3-chamber view of AS patients when compared to the control group. There was no significant association between the GLS and aortic root abnormality. Conclusion: Although the impaired longitudinal strain present in AS patients is not associated with the aortic root abnormality, it can be an early sign of cardiovascular involvement.

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Section: Discussionmentioning

confidence: 99%

Speckle Tracking Echocardiography in Patients with Ankylosing Spondylitis and Evaluation of Subclinical Involvement

Aghdashi,

Mikaeilvand,

Ansari-Ramandi

et al. 2023

MJR

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“…23 Since ankylosing spondylitis patients are 60% more likely than the general population to be hospitalised with (aortic) valve disease, it appears that aortic regurgitation might still be an important problem. 24 In an adult study, Ozen et al 25 evaluated aortic stiffness as a measure of cardiac disease using arterial stiffness and the associated haemodynamic changes for an independent predictor and risk factor for cardiovascular mortality and morbidity. They suggested that arterial stiffness has been directly associated with systolic hypertension, coronary artery disease, stroke, and cardiac failure.…”

Section: Discussionmentioning

confidence: 99%

Unexpected increase of aortic stiffness in juvenile Spondyloarthropathies

et al. 2020

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Juvenile spondyloarthropathy is an umbrella term for a group of childhood rheumatic diseases that can cause chronic arthritis extending to the axial skeleton before the age of 16. Although ankylosing spondylitis has aortic involvement as one of its most important effects, this relationship has not been extensively studied in children with juvenile spondyloarthropathy. Here, a cross-sectional study of the elastic properties of the aorta of 43 patients with juvenile spondyloarthropathy and 19 healthy controls is reported. Aortic stiffness assessed by echocardiography was used to predict the presence of aortitis, supplemented by pulsed-wave tissue Doppler indices. The right ventricular fractional area change was found to be significantly lower in the patients with juvenile spondyloarthropathy than in the healthy controls; aortic strain and distensibility were also significantly lower, and aortic stiffness index β was significantly higher; and the aortic root diameter change was significantly lower. According to HLA-B27 positivity, there was no difference in the stiffness parameters between the two groups. There was a significant correlation between juvenile Ankylosing Spondylitis Disease Activity Index and aortic diameter change, between juvenile Ankylosing Spondylitis Disease Activity Index and aortic stiffness. Thus, juvenile spondyloarthropathy is linked to high aortic stiffness parameters.

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“…The main imaging modalities used for evaluation of myocardial status in SpA include echocardiography and cardiovascular magnetic resonance (CMR). Subclinical cardiac dysfunction was identified in AS patients despite well controlled musculo-skeletal disease, using echocardiography [59]. Furthermore, aortic stiffness and left ventricular global longitudinal strain (LVGLS) were increased in AS patients [59].…”

Section: Role Of Imaging For Cardiac Assessment In Spamentioning

confidence: 99%

“…Subclinical cardiac dysfunction was identified in AS patients despite well controlled musculo-skeletal disease, using echocardiography [59]. Furthermore, aortic stiffness and left ventricular global longitudinal strain (LVGLS) were increased in AS patients [59]. In another echocardiographic study, early, subclinical myocardial dysfunction was observed in inflammatory joint disease (IJD) patients with preserved left-ventricular ejection fraction, but without traditional CV risk factors.…”

Section: Role Of Imaging For Cardiac Assessment In Spamentioning

confidence: 99%

Pathophysiology of Bone and Cardiac Involvement in Spondyloarthropathies: The indispensible value of magnetic resonance imaging

SI¹,

Nikas²,

Bonou³

et al. 2021

Trends Med

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Ankylosing spondylitis (AS) is the commonest expression of SpA. It is 2-3 times more common in men than women. IBP in a young patient is the most frequent symptom, but peripheral arthritis and/or enthesopathy may be found in some patients. Uveitis, positive family history for AS, impaired spinal mobility or chest expansion, all supports the diagnosis of AS [1].Axial involvement is one of the disease characteristics and 90% of patients have radiographic sacroiliitis during the course of the disease. Currently, a patient can be classified as having definite AS, if at least one clinical criterion (IBP, limitation of lumbar spine or limitation of chest expansion) plus a radiologic criterion (bilaterally grade 2 or unilateral grade 3-4 sacroiliitis) are fulfilled [9].

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Subclinical cardiac disease in ankylosing spondylitis

Cited by 10 publications

References 28 publications

Speckle Tracking Echocardiography in Patients with Ankylosing Spondylitis and Evaluation of Subclinical Involvement

Speckle Tracking Echocardiography in Patients with Ankylosing Spondylitis and Evaluation of Subclinical Involvement

Unexpected increase of aortic stiffness in juvenile Spondyloarthropathies

Pathophysiology of Bone and Cardiac Involvement in Spondyloarthropathies: The indispensible value of magnetic resonance imaging

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