Subclinical Hypothyroidism Affects Mitochondrial Function

Kvetny, Jan; Wilms, Line Kønig; Pedersen, Palle; Larsen, Jacob

doi:10.1055/s-0030-1248261

Cited by 27 publications

(23 citation statements)

References 18 publications

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“…In either situation, hemithyroidectomy induces a decrease in the metabolic state to which the individual was adapted preoperatively. We have previously demonstrated increased mitochondrial processes, and thereby increased MMP, in PBMCs of patients with subclinical hypothyroidism compared with controls [4], and the present study has reproduced these results in a hemithyroidectomized patient group, using two different measures of MMP. Subclinical hypothyroidism is associated with an increased risk of coronary heart disease [13,14], and recent studies have demonstrated an association between low thyroid function within the euthyroid range and various cardiovascular risk markers [15,16].…”

Section: Discussionsupporting

confidence: 82%

“…Respiratory gas analysis and volume measurements were performed with a canopy connected by a triple V (flow/gas sensor) to an Oxycon Pro apparatus (Jaeger Oxycon Champion, Breda, The Netherlands), as previously described [4]. The relation between V˙ O 2 and MMP was examined, and we observed a significant correlation between measurements of V˙ O 2 and the MMP of MTG-stained PBMCs (r = 0.46, p = 0.03), indicating that V˙ O 2 reflects inner mitochondrial membrane O 2 consumption.…”

Section: Methodsmentioning

confidence: 99%

“…Thyroid hormones regulate a number of cellular functions, a major one of which is regulation of mitochondrial energy production [2] and biogenesis [3], and we have previously described impaired thyroid hormone-regulated mitochondrial function in patients with subclinical hypothyroidism [4]. Therefore, we aimed to examine individual changes in TSH and thyroid hormones after hemithyroidectomy, focusing on tissue response to hemithyroidectomy-induced thyroid functional changes by examining the mitochondrial function of peripheral blood mononuclear cells (PBMCs) before and during the first year after hemithyroidectomy for benign euthyroid goiter.…”

Section: Introductionmentioning

confidence: 99%

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Persistent Cellular Metabolic Changes after Hemithyroidectomy for Benign Euthyroid Goiter

Kristensen¹,

Larsen²,

Pedersen³

et al. 2014

Eur Thyroid J

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Background: The significance of perturbations of thyroid-stimulating hormone (TSH) and thyroid hormones within the laboratory reference ranges after hemithyroidectomy is unknown. Our aim was to examine changes in TSH and thyroid hormones after hemithyroidectomy for benign euthyroid goiter, focusing on tissue response by examining the mitochondrial membrane potential (MMP) of peripheral blood mononuclear cells (PBMCs) and basal oxygen consumption (V˙O₂). Materials and Methods: In a prospective study on 28 patients and controls, we examined serum TSH and thyroid hormones before hemithyroidectomy and 1, 3, 6 and 12 months after hemithyroidectomy for benign euthyroid goiter. In the hemithyroidectomy group, flow cytometry was used to measure the MMP of tetramethylrhodamine methyl ester (TMRM)- and MitoTracker Green (MTG)-stained PBMCs, and V˙O₂ was measured by an Oxycon Pro apparatus. Results: One year after hemithyroidectomy, TSH had increased from a median of 0.97 mIU/l (interquartile range, IQR: 0.69-1.50 mIU/l) to 2.10 mIU/l (IQR: 1.90-3.00 mIU/l; p < 0.001); free thyroxine (fT₄) had decreased from a median of 16.0 pmol/l (IQR: 14.9-17.0 pmol/l) to 14.8 pmol/l (IQR: 14.1-16.4 pmol/l; p = 0.009), whereas total triiodothyronine variations did not differ from those in controls. Concomitantly, the MMP of TMRM- and MTG-stained PBMCs was increased by 58% (p < 0.001) and 22% (p = 0.008), respectively. V˙O₂ was increased by 14% (p = 0.01). Conclusion: Hemithyroidectomy for benign euthyroid goiter induced persistently increased TSH and decreased fT₄, sustained mitochondrial hyperpolarization and increased V˙O₂. Our results demonstrate a decrease after hemithyroidectomy of the metabolic state to which the individual is adapted, with persistent cellular metabolic changes in a hemithyroidectomized patient group which is normally considered clinically and biochemically euthyroid.

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Section: Discussionsupporting

confidence: 82%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Persistent Cellular Metabolic Changes after Hemithyroidectomy for Benign Euthyroid Goiter

Kristensen¹,

Larsen²,

Pedersen³

et al. 2014

Eur Thyroid J

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“…Even low-normal free thyroxin levels in patients with euthyroidism have been associated with insulin resistance (22,23). Thyroid disease induces mitochondrial dysfunction (24)(25)(26)(27), and statins reduce levels of coenzyme Q10, a component of the electron transport chain involved in the process of ATP generation (28), also leading to mitochondrial dysfunction as well as causing reduced insulin release and pancreatic b-cell failure and contributing to the development of DM (29)(30)(31)(32). Downregulation of GLUT4 in adipocytes has also been shown to be a result of statin treatment, an effect that has been explained in terms of reduced isoprenoid biosynthesis (33).…”

Section: Discussionmentioning

confidence: 99%

Hypothyroidism Is a Risk Factor for New-Onset Diabetes: A Cohort Study

et al. 2015

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OBJECTIVETo identify risk factors for the development of statin-associated diabetes mellitus (DM). RESEARCH DESIGN AND METHODSThe study was conducted in two phases. Phase one involved high-throughput in silico processing of a large amount of biomedical data to identify risk factors for the development of statin-associated DM. In phase two, the most prominent risk factor identified was confirmed in an observational cohort study at Clalit, the largest health care organization in Israel. Time-dependent Poisson regression multivariable models were performed to assess rate ratios (RRs) with 95% CIs for DM occurrence. RESULTSA total of 39,263 statin nonusers were matched by propensity score to 20,334 highly compliant statin initiators in [2004][2005] CONCLUSIONSHypothyroidism is a risk factor for DM. Subclinical hypothyroidism-associated risk for DM is prominent only upon statin use. Identifying and treating hypothyroidism and subclinical hypothyroidism might reduce DM risk. Future clinical studies are needed to confirm the findings.Thyroid disease is common in the general population. Hypothyroidism and subclinical hypothyroidism are more prevalent in patients with type 2 diabetes mellitus (DM), and it is possible that hypothyroidism is a risk factor for the development of DM. Women with subclinical hypothyroidism are more likely to develop gestational diabetes (1). After restoration of thyroid function, reduction of glucose-stimulated insulin secretion has been shown in patients with hypothyroidism as well as in those with subclinical hypothyroidism (2).

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“…In vitro studies showed that SCH can lead to energy expenditure and affect cell functions (29). Thyroid functions are determined through metabolic parameters.…”

Section: Discussionmentioning

confidence: 99%

The Evaluation of Metabolic Syndrome Parameters of Patients with Hashimoto’s Thyroiditis

Özkan¹,

Kayataş²

2016

Istanbul Med J

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Objective: In this study, we aimed to investigate the relationship between the prevalence of metabolic syndrome (MS) and the relationship between MS parameters in patients diagnosed with Hashimoto's thyroiditis (HT). Methods:A total of 100 patients admitted to the internal medicine clinic between July and March 2013 and diagnosed with HT were included in this study. Age, gender, height, weight, waist circumference, arterial blood pressure, fasting blood glucose, HDL cholesterol, and triglyceride levels were recorded. Patients were evaluated according to the diagnostic criteria of the MS in the National Cholesterol Education Program -Adult Treatment Panel III (NCEP-ATP III) -2001. Results:The ages of HT patients included in the study ranged from 19 to 67 years, with an average of 45.00±12.20 years; 90% of patients were females. According to the NCEP-ATP III diagnostic criteria, MS was observed in 30% of patients (n=30). We observed abdominal obesity in 73.3% of the patients (n=22), hyperglycemia in 73.3% (n=22), hypertriglyceridemia in 60% (n=18), hypertension in 46.7% (n=14), and low high-density lipoprotein cholesterol (HDL-K) in 86.7% of the patients diagnosed with MS (n=26). We also noted a statistically significant difference between thyroid stimulating hormone (TSH) levels of patients and the presence of MS (p<0.01). TSH levels were higher than normal levels in patients with MS. Conclusion:Various parameters of MS are frequent among patients with HT, and ideal level of MS parameters should be aimed during the treatment. Keywords:Hashimoto's thyroiditis, metabolic syndrome, thyroid stimulating hormone IntroductionHashimoto's thyroiditis (HT) is one of the most common causes of hypothyroidism along with goiter. HT is defined by diffuse mononuclear cell infiltration, decreased thyroid follicles with fibrosis, large thyrocytes called Hurthle cells that have a granular pink cytoplasm, and the presence of anti-thyroid peroxidase antibody (anti-TPO) and anti-thyroglobulin antibody (anti-TG) in the circulation (1). The incidence of HT is 0.3-1.5 per 1000 individuals per year (2). The disease is often encountered at ages ranging from 30 years to 50 years, and approximately 95% of patients are females (3). It can present with various clinical pictures. These include euthyroidism or subclinical hypothyroidism with goiter, overt hypothyroidism, and changing hypo-hyperthyroidism (4).The characteristic features of metabolic syndrome (MS) are central obesity, hypertension, dyslipidemia, glucose intolerance, vascular inflammation, and prothrombotic state (5). According to the data of Turkish Adult Heart Diseases and Risk Factor Study 2000, MS was detected in 28% of Turkish males and in 45% of Turkish females at the age of 30 years and above. It is estimated that approximately 9.1 million people at the age of 30 years and above have MS in Turkey (6). In this study, it was aimed to investigate the relationship between the frequency of MS and MS parameters in patients with HT. MethodsData of 100 patients who were admitted to ...

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Subclinical Hypothyroidism Affects Mitochondrial Function

Cited by 27 publications

References 18 publications

Persistent Cellular Metabolic Changes after Hemithyroidectomy for Benign Euthyroid Goiter

Persistent Cellular Metabolic Changes after Hemithyroidectomy for Benign Euthyroid Goiter

Hypothyroidism Is a Risk Factor for New-Onset Diabetes: A Cohort Study

The Evaluation of Metabolic Syndrome Parameters of Patients with Hashimoto’s Thyroiditis

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