Subclinical Hypothyroidism among local adult obese population

Abstract

Objective:To determine the frequency of subclinical hypothyroidism in local adult obese population.Methods:The study was conducted at Hayatabad Medical Complex, Peshawar, from March, 2017 to August, 2017. All patients aged between 18 and 60 years with BMI of more than 29kg/m2 were included in the study. Patients on lipid lowering drugs, with renal failure, hepatic failure and already diagnosed cases of thyroid dysfunction were excluded from the study. Thyroid functions were measured for all patients.Results:A total of 127 adults were included in the study in a consecutive manner. Mean age was 34.5 + 7.9 years of which 46.5% were male and 53.5% were female. Mean BMI was 32.05±2.06 kg/m2. The mean serum TSH was 3.13±1.10 mIU/L and mean serum thyroxine level was 1.08±0.25ng/dl. Subclinical hypothyroidism was recorded in 15% of the study population.Conclusion:Subclinical hypothyroidism is highly prevalent in our population with BMI of more than 29kg/m2. Further studies are recommended on relationship between thyroid functions and BMI and its effect on cardiovascular functions.

Correlation of Subclinical Hypothyroidism With Polycystic Ovary Syndrome (PCOS)

“…When TSH binds to the receptor in adipocytes, it stimulates interleukin-6 release from adipocytes and then mediates proliferation, differentiation, and leptin secretion of preadipocytes and adipocytes [16]. The growing evidence also suggests an association of altered thyroid function and obesity causes a lasting state of low-grade inflammation, while Nayak et al found no association between obesity and subclinical hypothyroidism among PCOS patients [17][18].…”

Association of Thyroid Function with Body Mass Index in Adolescent Girls

“…Studies have been published with data that even unit change in TSH level can alter the components of fat metabolism by 3%. 13,14 Thyroid hormones have an association with weight and adipose tissue. Hypothyroidism is associated with a decrease in metabolic rate and affects both lipid and carbohydrate metabolism.…”

Common Electrolyte and Metabolic Abnormalities Among Thyroid Patients

“…Reduction in metabolic activities and thermal regulation leading to increased weight gain and obesity are usually consequences of hypothyroidism. Previous investigations have referred to a potential association between subclinical hypothyroidism and weight gain, through the potential effects on lipid metabolism, which can eventually increase the risk of cardiovascular diseases as well (Figure 1 ) [ 38 - 39 ]. On the other hand, patients with hyperthyroidism usually suffer from weight loss, although it has been frequently reported that these patients usually have increased appetite and energy production [ 40 ].…”