Subclinical hypothyroidism and subclinical hyperthyroidism

Fatourechi, Vahab

doi:10.1586/eem.10.2

Cited by 4 publications

(2 citation statements)

References 130 publications

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“…This means the gland is not producing enough thyroid hormone, specifically Triiodothyronine (T3) and Thyroxine (T4), for various reasons. [1,2] There are numerous eye complications related to HAO, including dry eyes, swelling around the eyes, blurred vision, glaucoma, cataracts, and more. [3] The levels of thyroid hormones in a person's body can affect their oxidative and antioxidative status.…”

Section: Introductionmentioning

confidence: 99%

Intermittent Fasting and Vitamin E Supplementation Attenuates Hypothyroidism‐Associated Ophthalmopathy

Kumar,

Das,

Kumari

et al. 2024

Molecular Nutrition Food Res

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Visualization is a complex‐integrated procedure of the eyes and brain that allows to see this colorful world. Hypothyroidism‐associated ophthalmopathy (HAO), often known as dry eyes, swelling around the eyes, blurred vision, glaucoma, and cataracts, are some eye‐related issues caused by hypothyroidism. Yet there is no permanent cure for hypothyroidism; taking medicine throughout life is the only solution to keep its harmful effects under control. This study used intermittent fasting (IF) and vitamin E (Vit.E) supplementation to prevent hypothyroidism‐associated ophthalmopathy. This study hypothesized that intermittent fasting‐like diet regimens and vitamin supplementation should reduce the propagation of HAO by its antioxidant potential. In the present study, experimental animals are divided into five groups: normal, hypothyroidism control, dual, Vit. E, and IF. Hypothyroidism is generated in the experimental groups by taking propylthiouracil (PTU) for 24 days while also taking IF and Vit. E supplements. The hypothyroid‐induced experimental animals demonstrated an increase in IOP and lipid peroxidation while thyroid hormone levels depicted a massive decline which is a clear denotation of the effects of the thyroid on eyes and lifestyle. Ancient Ayurveda inspires these proposed therapies and has successfully reduced all the damage to the thyroid gland and the eye.

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Section: Introductionmentioning

confidence: 99%

Intermittent Fasting and Vitamin E Supplementation Attenuates Hypothyroidism‐Associated Ophthalmopathy

Kumar,

Das,

Kumari

et al. 2024

Molecular Nutrition Food Res

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show abstract

“…The SCH was distinguished by the degree of TSH in clinical diagnosis. TSH normal laboratory reference range was 0.3-5.0 mIU/L, and higher than 5 mIU/L was regarded as SCH [2][3][4][5]. However, the TSH range defining SCH remained elusive [3], and few molecular mechanisms were investigated in subclinical hypothyroidism.…”

Section: Introductionmentioning

confidence: 99%

Identification of related long non-coding RNAs and mRNAs in subclinical hypothyroidism complicated with type 2 diabetes by transcriptome analysis — a preliminary study

Jiang

Sun

et al. 2020

Endokrynologia Polska

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Introduction: The pathology mechanism of subclinical hypothyroidism and subclinical hypothyroidism complicated with type 2 diabetes remained uncertain. We aimed to find potential related long non-coding RNAs (lncRNAs) and mRNAs in the above diseases. Material and methods: Transcriptome sequencing was performed in three patients with subclinical hypothyroidism (S), three patients with subclinical hypothyroidism complicated with type 2 diabetes (SD), and three healthy controls (N). Differentially expressed mRNAs (DEmRNAs) and differentially expressed lncRNAs (DElncRNAs) were screened in S vs. N, SD vs. N, and SD vs. S group, and the nearby and co-expressed DEmRNAs of DElncRNAs were screened in S vs. N and SD vs. N. Moreover, functional analysis of DEmRNAs was then performed by Metascape. Results: In total, 465, 1058, and 943 DEmRNAs were obtained in S vs. N, SD vs. N, SD vs. S, respectively, and 191 overlapping genes were obtained in S vs. N and SD vs. N group. Among which, LAIR2, PNMA6A, and SFRP2 were deduced to be involved in subclinical hypothyroidism, and GPR162, APOL4, and ANK1 were deduced to be associated with subclinical hypothyroidism complicated with type 2 diabetes. A total of 50, 100, and 88 DElncRNAs were obtained in S vs. N, SD vs. N and SD vs. S, respectively. Combining with the interaction network of DElncRNA-DEmRNA, PAX8-AS1, co-expressed with KIR3DL1, was identified to function in subclinical hypothyroidism, and JHDM1D-AS1, co-expressed with ANK1, was deduced to play a role in subclinical hypothyroidism complicated with type 2 diabetes. Conclusions: Dysfunctional lncRNAs and mRNAs may be involved in the development of subclinical hypothyroidism and subclinical hypothyroidism complicated with type 2 diabetes.

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Thyroid dysfunction among patients assessed by thyroid function tests at a tertiary care hospital: a retrospective study

Aryee,

Aidoo,

Ababio

et al. 2024

Pan Afr Med J

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Introduction previous studies in African populations have not extensively described the spectrum of thyroid dysfunction using the profile of thyroid hormones. Although iodine deficiency is a common thyroid disorder in Africa, it does not represent the entire spectrum of thyroid dysfunction seen in patients. This retrospective study aimed to describe the spectrum of thyroid dysfunction among patients seen at the Korle-Bu Teaching Hospital (KBTH), a tertiary care hospital in Accra, Ghana. Methods a retrospective analysis of medical records of all consultations on thyroid disorders seen at the Internal Medicine Department of KBTH between January 2019 and December 2021 was conducted. Information on patient demographics, and thyroid hormone profiles (triiodothyronine - FT3, thyroxine - FT4, and thyroid stimulating hormone - TSH) were extracted and subjected to descriptive statistics. The thyroid hormone profiles of the subjects were analyzed and classified into thyroid dysfunction categories using guidelines from the American Thyroid Association (ATA). Results out of the 215 patients with thyroid disorders enrolled, 85.1% (n=183) were females and 14.9% (n=32), were males. The mean age of patients was 45±14 years, with most of the patients within the age range of 31-50 years (49.3%; n=106). The most reported thyroid function dysfunction was primary hyperthyroidism (57.7%), followed by primary hypothyroidism (22.3%), subclinical hyperthyroidism (9.3%), euthyroid sick syndrome (6.5%), and subclinical hypothyroidism (4.6%) respectively. Conclusion primary hyperthyroidism was the most commonly diagnosed thyroid dysfunction. Hyperthyroidism has been associated with cardiac morbidity and mortality. Timely interventions are required to reduce the morbidity risks and burden associated with the hyperthyroid state.

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Subclinical hypothyroidism and subclinical hyperthyroidism

Cited by 4 publications

References 130 publications

Intermittent Fasting and Vitamin E Supplementation Attenuates Hypothyroidism‐Associated Ophthalmopathy

Intermittent Fasting and Vitamin E Supplementation Attenuates Hypothyroidism‐Associated Ophthalmopathy

Identification of related long non-coding RNAs and mRNAs in subclinical hypothyroidism complicated with type 2 diabetes by transcriptome analysis — a preliminary study

Thyroid dysfunction among patients assessed by thyroid function tests at a tertiary care hospital: a retrospective study

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